Genetic Polymorphisms and Recurrent Spontaneous Abortions: An Overview of Current Knowledge

Daher, Sílvia; Mattar, Rosiane; Gueuvoghlanian-Silva, Bárbara Yasmin; Torloni, Maria Regina

doi:10.1111/j.1600-0897.2012.01123.x

Cited by 73 publications

(63 citation statements)

References 73 publications

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“…Our results demonstrated that RM patients had a significantly lower frequency of the G allele of rs1799983, which is consistent with previous studies in Koreans (Shin et al, 2010), whites (Hefler et al, 2002), and Indians (Parveen et al, 2011). By contrast, some studies have not confirmed this association (Daher et al, 2012).…”

Section: Discussionsupporting

confidence: 83%

Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage

Luo¹,

Li²,

Shan³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Endothelial nitric oxide synthase (eNOS) is an enzyme that influences placental human chorionic gonadotropin production during gestation. Previous studies have indicated an association between eNOS activity, implantation, and maintenance of pregnancy, but proposed associations between polymorphisms of the eNOS gene and recurrent miscarriage (RM) are controversial. To identify markers contributing to the genetic susceptibility to RM, we examined the potential association between RM and 8 single nucleotide polymorphisms (SNPs; rs1799983, rs2070744, rs11771443, rs3918188, rs2853796, rs7830, rs1541861, and rs2853792) of the eNOS gene using the MassARRAY system (Sequenom, USA). The enrolled participants included 192 RM patients and 201 women with normal fertility as controls. The results showed that rs1799983 at exon 7 of the eNOS gene was significantly associated with RM (genotype: chi-square = 15.071, P = 0.001; allele: chi-square = 6.250, P = 0.016). Another significant association was observed for rs11771443 in the promoter (genotype: chi-square = 6.259, P = 0.044; allele: chi-square = 7.076, P = 0.008). Furthermore, strong linkage disequilibrium was observed in 3 blocks (Dꞌ > 0.9), and significantly fewer T-T-G haplotypes (chi-square = 5.981, P = 0.015) residing in block 1 were found in RM patients. These findings point to a role for eNOS gene polymorphisms in RM in the Chinese Han population and may be informative for future genetic or neurobiological studies of RM.

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Section: Discussionsupporting

confidence: 83%

Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage

Luo¹,

Li²,

Shan³

et al. 2013

Genet. Mol. Res.

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show abstract

“…Dysregulated immunity was proposed as a potential mechanism underlying RPL 3,24 and that interindividual variation in the anti-inflammatory and proinflammatory cytokine levels may modify the risk of unexplained RPL. 7,25 In this regard, the success of pregnancy depends on maintaining a fine balance between Th1 and Th2 immunity. 26 This was reportedly characterized by a shift to Th2 (humoral) immunity, which involves augmentation in the production of Th2 cytokines accompanied by attenuation of Th1 cytokines synthesis.…”

Section: Discussionmentioning

confidence: 99%

Association between functional polymorphisms of Foxp3 and Interleukin-21 genes with the occurrence of recurrent pregnancy loss in Gaza strip-Palestine

Jaber

Sharif

2014

Int J Res Med Sci

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“…Several studies have been carried out to evaluate the relationship between cytokines, angiogenic mediators, and hormones gene polymorphisms and unexplained recurrent spontaneous abortion. The results of these studies are mostly contradictory, and few significant associations have been identified (1). Up to present time, the evidence is insufficient to support the evaluation of cytokines, angiogenic mediators, and hormones gene polymorphism in routine workup in all cases of recurrent pregnancy loss, and many of these genetic tests have not yet implemented the major obstetric guidelines.…”

Section: E] Cytokines Genes Factor (Insert Ref (7)mentioning

confidence: 93%

Review Article: Causes of Recurrent of Abortion

Alkhuriji¹,

Alumor²,

Haffor³

2017

ijcrr

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Abstract:Reoccurrence of Spontaneous abortion (RSA) in pregnant women is frequently encountered complications with no apparent cause. Multiple environmental and genetic factors had been studied that included; hereditary factors, hematologic and immunologic factors, endocrine factors and lifestyle factors. The key aspects of chromosomal abnormalities in RSA women were reviewed. The central theme of the hematologic and immunologic factors focused on studiesthat associated RSA to infection, clot formation, proinflammatory and anti-inflammatory cytokines as well as their genes polymorphism. The factors that underlie hormonal abnormalities and occupational hazards as they pertain to RSA were also reviewed. To conclude genes polymorphisms of inflammatory and anti-inflammatory cytokines seem promising to establish causal molecular relations with RSA.

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Genetic Polymorphisms and Recurrent Spontaneous Abortions: An Overview of Current Knowledge

Abstract: CitationDaher S, Mattar R, Gueuvoghlanian-Silva BY, Torloni MR. Genetic polymorphisms and recurrent spontaneous abortions: an overview of current knowledge.

Cited by 73 publications

References 73 publications

Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage

Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage

Association between functional polymorphisms of Foxp3 and Interleukin-21 genes with the occurrence of recurrent pregnancy loss in Gaza strip-Palestine

Review Article: Causes of Recurrent of Abortion

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