Genetic Polymorphisms in Critical Illness and Injury

Dahmer, Mary K.; Quasney, Michael W.

doi:10.1007/978-1-4471-6362-6_19

Cited by 1 publication

(2 citation statements)

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“…TNFα resides approximately 252 base pairs downstream of the transcription start site for the gene coding TNFβ (also known as lymphotoxin alpha) 41 . As an inflammatory mediator, TNF‐α affects the production of other cytokines.…”

Section: Discussionmentioning

confidence: 99%

“…TNFα resides approximately 252 base pairs downstream of the transcription start site for the gene coding TNFβ (also known as lymphotoxin alpha). 41 As an inflammatory mediator, TNF‐α affects the production of other cytokines. However, the interaction between cytokines might result in antagonistic (TNF‐α and TNF‐β, for instance) or synergistic (e.g., TNF‐α with IL‐1 interactions) effects.…”

Section: Discussionmentioning

confidence: 99%

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Association of polymorphisms in tumor necrosis factors with SARS‐CoV‐2 infection and mortality rate: A case‐control study and in silico analyses

Nia

Rokni

Mirinejad

et al. 2021

Journal of Medical Virology

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The present coronavirus disease 2019 is spreading rapidly and existing data has suggested a number of susceptibility factors for developing a severe course of the disease. The current case-control experiment is aimed to study the associations of genetic polymorphisms in tumor necrosis factors (TNFs) with COVID-19 and its mortality rate. A total of 550 participants (275 subjects and 275 controls) were enrolled. The tetra-amplification refractory mutation system polymerase chain reaction technique was recruited to detect −308G>A TNFα and +252A>G TNFβ polymorphisms among the Iranian subjects. We demonstrated that carriers of the G allele of TNFβ-252A/G, rs909253 A>G were more frequent in COVID-19 subjects compared to the healthy group and this allele statistically increased the disease risk (odds ratio [OR] = 1.55, 95% confidence interval [CI] = 1.23-1.96, p < 0.0001). At the same time, the A allele of TNFα-311A/G, rs1800629 G>A moderately decreased the risk of COVID-19 (OR = 0.68, 95% CI = 0.53-0.86, p < 0.002). Also, we analyzed the various genotypes regarding the para-clinical and disorder severity; we found that in the AA genotype of TNFβ-252A/G (rs909253 A>G), the computed tomography scan pattern was different in comparison to cases carrying the AG genotype with p 1 < 0.001. In addition, in the severe cases of COVID-19, leukocyte and neutrophil count and duration of intensive care unit hospitalization in the deceased patients were significantly increased (p < 0.001). Moreover, the TNFα-311A/G (rs1800629 G>A) variant is likely to change the pattern of splicing factor sites. Our findings provided deep insights into the relationship between TNFα/TNFβ polymorphisms and severe acute respiratory syndrome coronavirus 2. Replicated studies may give scientific evidence for exploring molecular mechanisms of COVID-19 in other ethnicities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%