Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study

Shatalova, Ekaterina G.; Walther, Susan E.; Фаворова, О. О.; Rebbeck, Timothy R.; Blanchard, Rebecca

doi:10.1186/bcr1318

Cited by 41 publications

(28 citation statements)

References 37 publications

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“…Additional assay validations were undertaken using direct sequencing (CYP1A1*2C), pyrosequencing (SULT1E1 À64G>A), and RFLP (COMT, CYP1B1*4, CYP3A4*1B). SULT1A1 genotypes were determined as previously reported (5,16). The control frequency distributions for these variants by race has also been previously reported (5).…”

Section: Methodsmentioning

confidence: 99%

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Pairwise Combinations of Estrogen Metabolism Genotypes in Postmenopausal Breast Cancer Etiology

Rebbeck¹,

Troxel²,

Walker³

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Estrogen exposures have been associated with breast cancer risk, and genes involved in estrogen metabolism have been reported to mediate that risk. Our goal was to better understand whether combinations of candidate estrogen metabolism genotypes are associated with breast cancer etiology. A population-based case-control study in three counties of the Philadelphia Metropolitan area was undertaken. We evaluated seven main effects and 21 first-order interactions in African Americans and European Americans for genotypes at COMT, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SULT1A1, and SULT1E1 in 878 breast cancer cases and 1,409 matched random digit -dialed controls. In European Americans, we observed main effect associations of genotypes containing any CYP1A1*2C (odds ratio, 1.71; 95% confidence interval, 1.09-2.67) and breast cancer. No significant main effects were observed in African Americans. Three significant first-order interactions were observed. In European Americans, interactions between SULT1A1*2 and CYP1A1*2C genotypes (P interaction < 0.001) and between SULT1E1 and CYP1A2*1F genotypes were observed (P interaction = 0.006). In African Americans, an interaction between SULT1A1*2 and CYP1B1*4 was observed (P interaction = 0.041). We applied the false-positive report probability approach, which suggested that these associations were noteworthy; however, we cannot rule out the possibility that chance led to these associations. Pending future confirmation of these results, our data suggest that breast cancer etiology in both European American and African American postmenopausal women may involve the interaction of a gene responsible for the generation of catecholestrogens with a gene involved in estrogen and catecholestrogen sulfation. (Cancer Epidemiol Biomarkers Prev 2007;16(3):444 -50)

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Section: Methodsmentioning

confidence: 99%

“…His (*2; rs9282861), and the SULT1E1 À64G>A promoter variant (rs3736599). COMT, CYP1A1, CYP1A2, CYP1B1, CYP3A4, and SULT1E1 were assayed using previously described methods (5,16). Additional assay validations were undertaken using direct sequencing (CYP1A1*2C), pyrosequencing (SULT1E1 À64G>A), and RFLP (COMT, CYP1B1*4, CYP3A4*1B).…”

Section: Methodsmentioning

confidence: 99%

Pairwise Combinations of Estrogen Metabolism Genotypes in Postmenopausal Breast Cancer Etiology

Rebbeck¹,

Troxel²,

Walker³

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Recently, mutations in the SULT1E1 gene have also been reported; however, the mutation frequencies in the population studied were very low (Adjei et al, 2003). The possible association between SULT1A1 pharmacogenetics (SULT1A1 normal-activity *1 and low-activity *2 alleles) and cancer has been evaluated in several studies (Seth et al, 2000;Bamber et al, 2001;Zheng et al, 2001;Wang et al, 2002;Tang et al, 2003;Wu et al, 2003;Choi et al, 2005;Nowell et al, 2005;Shatalova et al, 2005). These studies provide epidemiological evidence for associations among diet, genetics, and cancer risk.…”

mentioning

confidence: 99%

Variable Sulfation of Dietary Polyphenols by Recombinant Human Sulfotransferase (SULT) 1A1 Genetic Variants and SULT1E1

Ung¹,

Nagar²

2007

Drug Metab Dispos

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ABSTRACT:Human cytosolic sulfotransferases (SULTs) catalyze the sulfate conjugation of several important endo-and xenobiotics. Among the superfamily of SULT enzymes, SULT1A1 catalyzes the sulfation of small planar phenolic compounds, whereas SULT1E1 has a major role in estrogen conjugation. The human SULT1A1 gene has common single nucleotide polymorphisms that define three allozymes, SULT1A1*1, *2, and *3. The enzyme kinetics of SULT1A1 allozymes and SULT1E1 were characterized for the polyphenolic substrates apigenin, chrysin, epicatechin, quercetin, and resveratrol. Purified recombinant SULT proteins were generated in a baculoviral-insect cell system, and incubated in vitro with each substrate to determine catalytic activity. The effect of polyphenol sulfation was examined in mammalian cell lines stably expressing SULT1E1. For all polyphenols investigated, "normal-activity" SULT1A1*1 allozyme had significantly greater V max estimates than SULT1E1, and allele-specific differences in SULT1A1-mediated sulfation were observed. The polymorphic SULT1A1*2 allozyme exhibited low activity toward apigenin, epicatechin, and resveratrol. SULT1A1*1 and *3 acted as normal-activity allozymes for these substrates. Altered cellular proliferation was observed in MCF-7 cells stably expressing SULT1E1 upon treatment with chrysin, quercetin, or resveratrol, thus suggesting inactivation of these compounds by SULT1E1. These results suggest an important role for SULT isozymes and their pharmacogenetics in polyphenol disposition.

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“…One study was excluded as all the required information could not be obtained (Peng et al, 2003). Genotyping studies on only cancer cases or exclusively on healthy subjects were excluded as comparison of cancer patients with matched controls was a prerequisite for studying association of a particular genotype with cancer risk (Nowell et al, 2002b(Nowell et al, , 2005Magagnotti et al, 2003;Sparks et al, 2004;Shatalova et al, 2005;Grabinski et al, 2006).…”

mentioning

confidence: 99%

Case–control study and meta-analysis of SULT1A1 Arg213His polymorphism for gene, ethnicity and environment interaction for cancer risk

et al. 2008

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Cytosolic sulphotransferase SULT1A1 plays a dual role in the activation of some carcinogens and inactivation of others. A functional polymorphism leading to Arg 213 His substitution (SULT1A1*2) affects its catalytic activity and thermostability. To study the association of SULT1A1*2 polymorphism with tobacco-related cancers (TRCs), a case -control study comprising 132 patients with multiple primary neoplasm (MPN) involving TRC and 198 cancer-free controls was carried out. One hundred and thirteen MPN patients had at least one cancer in upper aerodigestive tract including lung (UADT-MPN). SULT1A1*2 showed significant risk association with UADT-MPN (odds ratio (OR) ¼ 5.50, 95% confidence interval (CI): 1.09, 27.7). Meta-analysis was conducted combining the data with 34 published studies that included 11 962 cancer cases and 14 673 controls in diverse cancers. The SULT1A1*2 revealed contrasting risk association for UADT cancers (OR ¼ 1.62, 95% CI: 1.12, 2.34) and genitourinary cancers (OR ¼ 0.73, 95% CI: 0.58, 0.92). Furthermore, although SULT1A1*2 conferred significant increased risk of breast cancer to Asian women (OR ¼ 1.91, 95% CI: 1.08, 3.40), it did not confer increased risk to Caucasian women (OR ¼ 0.92, 95% CI: 0.71, 1.18). Thus risk for different cancers in distinct ethnic groups could be modulated by interaction between genetic variants and different endogenous and exogenous carcinogens.

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Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study

Cited by 41 publications

References 37 publications

Pairwise Combinations of Estrogen Metabolism Genotypes in Postmenopausal Breast Cancer Etiology

Pairwise Combinations of Estrogen Metabolism Genotypes in Postmenopausal Breast Cancer Etiology

Variable Sulfation of Dietary Polyphenols by Recombinant Human Sulfotransferase (SULT) 1A1 Genetic Variants and SULT1E1

Case–control study and meta-analysis of SULT1A1 Arg213His polymorphism for gene, ethnicity and environment interaction for cancer risk

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