Genetic polymorphisms in lncRNAs predict recurrence of ischemic stroke

Zhu, Ruixia; Xiao, Tongling; Wang, Qianwen; Zhao, Yating; Liu, Xu

doi:10.1007/s11011-021-00725-4

Cited by 7 publications

(6 citation statements)

References 33 publications

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“…MEG3 SNPs are associated with multiple diseases including asthma, inflammatory response, diabetes, stroke, and cancer ( Wallace et al, 2010 ; Han et al, 2018 ; Ghaedi et al, 2018 ; Ghafouri-Fard & Taheri, 2019 ; Gao et al, 2021 ; Zhu et al, 2021 ; Zhong et al, 2022 ). Pleiotropy ( i.e., shared genetic predisposition loci to different human diseases and traits) is pervasive in human genome ( Sivakumaran et al, 2011 ; Pickrell et al, 2016 ; Tian et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…We selected four SNPs ( Fig. 2 ) that were either correlated with MEG3 expression or associated with other diseases in previous publications ( Han et al, 2018 ; Ghaedi et al, 2018 ; Ghafouri-Fard & Taheri, 2019 ; Gao et al, 2021 ; Zhu et al, 2021 ; Zhong et al, 2022 ). The MEG3 rs7158663 , rs3087918 , rs11160608 , and rs4081134 genotypes were determined using TaqMan assay with an ABI 7500 Real-Time PCR System (Applied Biosystems, Foster City, CA, USA) as previously described ( Pei et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

“…Given that aberrant MEG3 expression is linked to asthma development, we hypothesize that genetic variants that affect MEG3 expression may be associated with the risk of developing asthma. Several SNPs in MEG3 have been reported in literature that may affect MEG3 expression and influence the risks of various diseases including inflammatory response, diabetes, stroke, and cancer ( Wallace et al, 2010 ; Han et al, 2018 ; Ghaedi et al, 2018 ; Ghafouri-Fard & Taheri, 2019 ; Gao et al, 2021 ; Zhu et al, 2021 ; Zhong et al, 2022 ). We therefore perform the first study to evaluate the associations of SNPs in MEG3 with the risks of asthma using a case control study design.…”

Section: Introductionmentioning

confidence: 99%

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Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma

Chiu

Chang

Tsai

et al. 2023

PeerJ

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Background Asthma is the most common chronic inflammatory airway disease worldwide. Asthma is a complex disease whose exact etiologic mechanisms remain elusive; however, it is increasingly evident that genetic factors play essential roles in the development of asthma. The purpose of this study is to identify novel genetic susceptibility loci for asthma in Taiwanese. We selected a well-studied long non-coding RNA (lncRNA), MEG3, which is involved in multiple cellular functions and whose expression has been associated with asthma. We hypothesize that genetic variants in MEG3 may influence the risk of asthma. Methods We genotyped four single nucleotide polymorphisms (SNPs) in MEG3, rs7158663, rs3087918, rs11160608, and rs4081134, in 198 patients with asthma and 453 healthy controls and measured serum MEG3 expression level in a subset of controls. Results The variant AG and AA genotypes of MEG3 rs7158663 were significantly over-represented in the patients compared to the controls (P = 0.0024). In logistic regression analyses, compared with the wild-type GG genotype, the heterozygous variant genotype (AG) was associated with a 1.62-fold [95% confidence interval (CI) [1.18–2.32], P = 0.0093] increased risk and the homozygous variant genotype (AA) conferred a 2.68-fold (95% CI [1.52–4.83], P = 0.003) increased risk of asthma. The allelic test showed the A allele was associated with a 1.63-fold increased risk of asthma (95% CI [1.25–2.07], P = 0.0004). The AG plus AA genotypes were also associated with severe symptoms (P = 0.0148). Furthermore, the AG and AA genotype carriers had lower serum MEG3 expression level than the GG genotype carriers, consistent with the reported downregulation of MEG3 in asthma patients. Conclusion MEG3 SNP rs7158663 is a genetic susceptibility locus for asthma in Taiwanese. Individuals carrying the variant genotypes have lower serum MEG3 level and are at increased risks of asthma and severe symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma

Chiu

Chang

Tsai

et al. 2023

PeerJ

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“…This is in line with previous findings from a gene-centric meta-analysis in 68,368 individuals of European ancestry, showing a correlation between diastolic blood pressure and mean arterial pressure with rs217727 polymorphism [ 136 ]. Two other H19 polymorphisms, rs2107425 and rs2251375, however, were not associated with the age onset or recurrence of IS among 657 stroke patients from a Chinese population [ 137 ]. In contrast with the polymorphism studies in CAD, where several SNPs on H19 were shown to associate with reduced risk [ 71 , 121 ], none of these IS-associated SNPs are indicative of a decreased risk, which may be suggestive of a tissue-specific function of H19.…”

Section: The Multifaceted Role Of H19 In Cardiovascular Diseasementioning

confidence: 99%

The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases

2022

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Cardiovascular diseases are the leading cause of death and debility worldwide. Various molecular mechanisms have been studied to better understand the development and progression of cardiovascular pathologies with hope to eradicate these diseases. With the advancement of the sequencing technology, it is revealed that the majority of our genome is non-coding. A growing body of literature demonstrates the critical role of long non-coding RNAs (lncRNAs) as epigenetic regulators of gene expression. LncRNAs can regulate cellular biological processes through various distinct molecular mechanisms. The abundance of lncRNAs in the cardiovascular system indicates their significance in cardiovascular physiology and pathology. LncRNA H19, in particular, is a highly evolutionarily conserved lncRNA that is enriched in cardiac and vascular tissue, underlining its importance in maintaining homeostasis of the cardiovascular system. In this review, we discuss the versatile function of H19 in various types of cardiovascular diseases. We highlight the current literature on H19 in the cardiovascular system and demonstrate how dysregulation of H19 induces the development of cardiovascular pathophysiology.

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“…Further meta-analysis showed that thrombolysis is a highly effective treatment for achieving good clinical outcome, and the treatment time window can be further extended to 7.3 h. For patients with acute occlusion of large cerebral vessels within the thrombolysis time window, bridging therapy remains the gold standard, but it is still controversial whether endovascular treatment should be performed directly instead of intravenous thrombolysis. Some studies suggest that bridging within the time window of thrombolysis is not superior to direct endovascular therapy for ischemic stroke with large vessel occlusion in the anterior circulation, but there are no additional clinical studies to confirm this conclusion [ 17 , 18 ].…”

Section: Related Workmentioning

confidence: 99%

Prediction of Ischemic Stroke Recurrence Based on COX Proportional Risk Regression Model and Evaluation of the Effectiveness of Patient Intensive Care Interventions

Wang

2022

Computational and Mathematical Methods in Medicine

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With the continuous improvement of medical technology and the aging of the population, the death rate of stroke is gradually decreasing, but the recurrence rate is still high, and the number of recurrences is increasing, resulting in disability and other symptoms, which brings great burden and distress to patients and their families. As the number of strokes increases, neurological impairment becomes more and more severe, affecting patients’ ability to live, socialize, and work, and seriously reducing their quality of life. Clustered care is a combination of evidence-based linked interventions and a multidisciplinary team providing the best possible care through evidence-based research and highly operational practice, and it can improve outcomes for ischemic stroke patients more than implementation alone. This paper presents a Cox proportional risk regression-based model, using it to build the most used semi-parametric model for multifactorial survival analysis, due to its advantages of both parametric and nonparametric models, and to analyze the factors influencing survival time in study subjects with incomplete data. The proposed strategy has been found to be useful in predicting ischemic stroke recurrence and cluster care interventions for patients.

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Genetic polymorphisms in lncRNAs predict recurrence of ischemic stroke

Cited by 7 publications

References 33 publications

Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma

Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma

The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases

Prediction of Ischemic Stroke Recurrence Based on COX Proportional Risk Regression Model and Evaluation of the Effectiveness of Patient Intensive Care Interventions

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