Genetic polymorphisms in plasminogen activator inhibitor-1 predict susceptibility to steroid-induced osteonecrosis of the femoral head in Chinese population

Zhang, Yanqiong; Wang, Rongtian; Li, Shangzhu; Kong, Xiangying; Wang, Zhiyao; Chen, Weiheng; Lin, Na

doi:10.1186/1746-1596-8-169

Cited by 20 publications

(18 citation statements)

References 31 publications

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“…Environmental factors include type of prosthesis, implant design, material, surgical technique, fixation method, and postoperative rehabilitation procedure have been widely studied [ 13 , 14 ], but more and more attention is paid to the genetic factors like single nucleotide polymorphisms (SNPs). SNPs are genetic variations that are considered biologically normal and can be found in at least 1% of the population, which may contribute towards individual susceptibilities to certain pathological conditions [ 15 , 16 ]. Various gene SNPs of GNAS1, TNF-238, TNF-a, IL6-174, MMP1, MMP2, and et al were reported to be associated with increased prosthetic loosening.…”

Section: Introductionmentioning

confidence: 99%

Genetic susceptibility to total hip arthroplasty failure: a case-control study on the influence of MMP 1 gene polymorphism

Yan

Lü

et al. 2014

Diagn Pathol

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BackgroundGenetic factors plays an important role in early failure of total hip arthroplasty (THA) etiology and MMP-1 gene polymorphism rs5854 may be involved. The present study was conducted to reveal the possible association between MMP-1 rs5854 C/T polymorphism and the risk of early failure of THA (aseptic loosening).MethodsThe rs5854 single nucleotide polymorphism (SNP) in MMP-1 gene was genotyped in 63 subjects who were diagnosed as aseptic loosening after total hip arthroplasty within 10 years and in 81 age and gender matched controls.ResultsThe genotype frequencies of the MMP-1 rs5854 C/T polymorphism were 57.1% (CC), 28.6% (CT), and 14.3% (TT) in patients with failure of THA, and 79.0% (CC), 17.3% (CT), and 3.7% (TT) in the controls (P = 0.0099). Rs5854 polymorphism was found to be significantly associated with increased risk of aseptic loosening.ConclusionThe results showed the rs5854 SNP was associated with increased risk of the early aseptic loosening susceptibility.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_177

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Section: Introductionmentioning

confidence: 99%

Genetic susceptibility to total hip arthroplasty failure: a case-control study on the influence of MMP 1 gene polymorphism

Yan

Lü

et al. 2014

Diagn Pathol

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“…PAI-1 is the main and fast-acting inhibitor of fi brinolysis, it inhibits tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen. Therefore, it inhibits fi brinolysis and promotes thrombosis (56,(72)(73)(74). Increased plasma levels of the PAI-1 are associated with an increased incidence of trombophilia and AVN.…”

Section: Genetic Polymorphisms Involved In the Vascular Systemmentioning

confidence: 99%

“…Increased plasma levels of the PAI-1 are associated with an increased incidence of trombophilia and AVN. High levels of PAI-1, caused by PAI-1 gene polymorphism, either as a consequence of treatment with GCs, may lead to disturbance in blood fl ow to the femoral head and could result in bone AVN (56,73). French et al with other experts from Children's Oncology Group in 2008 pointed out the potential of PAI-1 polymorphism, that could predict AVN of bones.…”

Section: Genetic Polymorphisms Involved In the Vascular Systemmentioning

confidence: 99%

“…Kim et al in 2011 found a signifi cant correlation of three single nucleotide polymorphisms (SNPs) (4G allele of rs1799889, A allele of rs2227631 and C allele of rs11178) in the PAI-1 gene with higher risk of AVN of the femoral head development (72). In 2013, Zhang et al found a signifi cant association of SNPsrs11178 and rs2227631ofPAI-1 gene with steroid induced AVN of femoral head (73). In a metaanalysis of genetic risk factors for glucocorticoid-induced AVN, Gong et al have analyzed 23 publications with 35 candidate genes responsible for AVN.…”

Section: Genetic Polymorphisms Involved In the Vascular Systemmentioning

confidence: 99%

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Avascular necrosis of bone in childhood cancer patients: a possible role of genetic susceptibility

Geczova¹,

Šoltýsová²,

Gécz³

et al. 2015

BLL

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Abstract:With the increasing number of paediatric cancer patients and with their prolonged survival, the evidence of a number of serious complications induced by anticancer therapy is rising. Osteonecrosis (ON) of bone is one of these treatment-related effects with a multifactorial pathogenesis. In the past few years, several polymorphisms of candidate genes with possible role in development of this disorder were studied. We summarized potential risk factors leading to increased susceptibility to osteonecrosis of bone development in cancer patients during childhood and to present current knowledge in the fi eld of genetic aspects of this condition (Ref. 86). Text in PDF www.elis.sk.

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“…There were much less alcoholic female ONFH patients (5.9%) (Cui et al, ). Similarly, genetic factors play an important role in the development of steroid‐induced femoral head necrosis (Li et al, ; Wang et al, ; Zhang et al, ).…”

Section: Introductionmentioning

confidence: 99%

IL‐4 gene polymorphisms and their relation to steroid‐induced osteonecrosis of the femoral head in Chinese population

Jin

Zhang

Sun

et al. 2019

Molec Gen & Gen Med

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Background Steroid‐induced osteonecrosis of the femoral head (ONFH) is a debilitating disease characterized by the activation and infiltration of macrophages into the necrotic site. Interleukin‐4 ( IL‐4 ) administration helped reduce the infiltration of M1 phenotypic macrophages and maintain the activation of M2 phenotypic macrophages, resulting in restriction of inflammation and decrease in osteocyte apoptosis. The aim of this study was to investigate the associations of polymorphisms of IL‐4 gene with steroid‐induced ONFH in Chinese patients. Materials and methods A total of 286 steroid‐induced ONFH patients and 441 healthy controls were enrolled. We evaluated 6 single nucleotide polymorphisms of the IL‐4 gene in this case–control study. Results We identified rs2243283 in the IL‐4 gene was potentially associated with an increased risk of steroid‐induced ONFH in the dominant model ( p = 0.034; odds ratio [OR]: 1.40; 95% confidence intervals [CI]: 1.03–1.91) and in the log‐additive model ( p = 0.04; OR: 1.31; 95% CI: 1.01–1.71) adjusted by age and gender. Furthermore, we also observed a protective effect of rs2243289 in the dominant model ( p = 0.024; OR: 0.70; 95% CI: 0.51–0.95) adjusted by age and gender. Conclusion These findings suggested that polymorphisms of IL‐4 gene may be associated with susceptibility to steroid‐induced ONFH.

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Genetic polymorphisms in plasminogen activator inhibitor-1 predict susceptibility to steroid-induced osteonecrosis of the femoral head in Chinese population

Cited by 20 publications

References 31 publications

Genetic susceptibility to total hip arthroplasty failure: a case-control study on the influence of MMP 1 gene polymorphism

Genetic susceptibility to total hip arthroplasty failure: a case-control study on the influence of MMP 1 gene polymorphism

Avascular necrosis of bone in childhood cancer patients: a possible role of genetic susceptibility

IL‐4 gene polymorphisms and their relation to steroid‐induced osteonecrosis of the femoral head in Chinese population

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