Genetic polymorphisms in the DNA repair gene XRCC1 and susceptibility to glioma in a Han population in northeastern China: A case–control study

Wang, Dianhong; Hu, Yanqin; Gong, Haidong; Li, Jingwen; Ren, Yanhai; Li, Guozhong; Liu, Aiguo

doi:10.1016/j.gene.2012.08.023

Cited by 22 publications

(25 citation statements)

References 27 publications

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“…It could be used as molecular markers for evaluating glioma risk. Up to now, several similar studies concerned the influence of other genetic polymorphisms in the XRCC1 gene on glioma risk (Wang et al, 2004;Felini et al, 2007;Kiuru et al, 2008;Liu et al, 2009;Rajaraman et al, 2010;Yosunkaya et al, 2010;Hu et al, 2011;Melin, 2011;Zhou et al, 2011;Jacobs et al, 2012;Liu et al, 2012;Sun et al, 2012;Wang et al, 2012;Zhang et al, 2012;Jiang et al, 2013;Luo et al, 2013;Pan et al, 2013;Wei et al, 2013). Results from these observations are in accordance with our conclusion that the genetic polymorphisms of XRCC1 gene may contribute to influences on glioma risk (Kiuru et al, 2008;Liu et al, 2009;Rajaraman et al, 2010;Yosunkaya et al, 2010;Hu et al, 2011;Zhou et al, 2011;Liu et al, 2012;Sun et al, 2012;Wang et al, 2012;Jiang et al, 2013;Luo et al, 2013;Pan et al, 2013;Wei et al, 2013).…”

Section: Discussionsupporting

confidence: 83%

“…Genetic polymorphisms in XRCC1 gene (such as Arginine (Arg)194 Tryptophan (Trp), Arg280 Histidine (His) and Arg399 Glutanine (Gln) ) have been reported to be potential influence on the altered risk of glioma (Kiuru et al, 2008;Liu et al, 2009;Rajaraman et al, 2010;Yosunkaya et al, 2010;Hu et al, 2011;Zhou , 2011;Liu et al, 2012;Sun et al, 2012;Jiang et al, 2013;Luo et al, 2013;Pan et al, 2013;Wei et al, 2013). However, the results from these observations were conflicting rather than conclusive (Wang et al, 2004;Felini et al, 2007;Kiuru et al, 2008;Liu et al, 2009;Rajaraman et al, 2010;Yosunkaya et al, 2010;Hu et al, 2011;Melin, 2011;Zhou et al, 2011;Jacobs et al, 2012;Liu et al, 2012;Sun et al, 2012;Wang et al, 2012;Zhang et al, 2012;Jiang et al, 2013;Luo et al, 2013;Pan et al, 2013;Wei et al, 2013). Up to date, no related studies about the potential association between the c.1471G>A genetic polymorphism of XRCC1 gene and the risk of glioma have not been analyzed in any population.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Genetic Polymorphism of XRCC1 Gene and Risk of Glioma in а Chinese Population

Wang

Fan²,

Tao³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Gliomas are the most common type of primary brain tumor in adults, and the X-ray repair complementing group 1 gene (XRCC1) is an important candidate gene influencing its risk. The objective of this study was to detect the influence of XRCC1 genetic polymorphisms on glioma risk. Materials and Methods: A total of 629 glioma patients and 641 cancer-free subjects were enrolled in this case-control study. The genotypes of the c.1471G>A genetic polymorphism were determined by created restriction site-polymerase chain reaction (CRS-PCR) and DNA sequencing methods. The influence of the XRCC1 genetic polymorphism on glioma risk was evaluated by association analysis. Results: Our data indicated that the alleles/genotype of this genetic variant was statistically associated with glioma risk. The AA genotype was statistically associated with the increased risk of glioma compared to the GG wild genotype (odds ratios (OR) = 1.89, 95% CI 1.25-2.87, P = 0.003). The allele-A may contribute to increased the susceptibility to glioma (OR = 1.23, 95% CI 1.04-1.46, P = 0.017). Conclusions: These preliminary findings indicate that the c.1471G>A genetic polymorphism of XRCC1 has the potential to influence glioma susceptibility, and might be used as molecular marker for assessing glioma risk.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Association Between Genetic Polymorphism of XRCC1 Gene and Risk of Glioma in а Chinese Population

Wang

Fan²,

Tao³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Several previous studies have indicated that DNA repair gene polymorphisms play a role in the susceptibility to glioma (Wang et al, 2012;Chen et al, 2012;Jacobs and Bracken, 2012), but the association between polymorphisms in XPF SNPs and glioma risk has not yet been studied in a Chinese population. Our results suggest that the rs1800067 polymorphism may be used as a genetic susceptibility marker for glioma and as an identification index for high-risk individuals.…”

Section: Discussionmentioning

confidence: 99%

Association of polymorphisms of the xeroderma pigmentosum complementation group F gene with increased glioma risk

Zhou¹,

Huang²,

Hui³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. We aimed to investigate the role of 4 single nucleotide polymorphisms of the xeroderma pigmentosum complementation group F (XPF) gene (rs3136038, rs1799798, rs1800067, and rs2276466) in glioma, and the roles of gene-gene interactions in the risk of developing this type of cancer. We collected samples from 225 glioma cases and 262 controls and genotyped the rs3136038, rs1799798, rs1800067, and rs2276466 polymorphisms using a 384-well plate format with the Sequenom MassARRAY platform. Individuals carrying the rs1800067 GG genotype were more likely to have an increased risk of glioma when compared with carriers of the A/A genotype in a co-dominant model, with an odds ratio (OR) [95% confidence interval (CI)] of 2.85 (1.14-7.76). However, we did not find an association with increased risk of glioma for the polymorphisms rs3136038, rs1799798, and rs2276466 XPF polymorphisms and glioma risk in XPF. The combination genotype of the rs1800067 G allele and the rs2276466 G allele was associated with a moderate risk of glioma (OR = 1.71, 95%CI = 1.02-2.87). Our study suggests that the rs1800067 genetic variant of XPF functions in the development of glioma.

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“…Among them, the XRCC1 Arg194Trp variant located in the proliferating cell nuclear antigen (PCNA) binding region, which suggests that this mutation may be result in gliomagenesis. However, these studies have failed to yield a consistent conclusion (Kiuru et al, 2008;Liu et al, 2009;McKean-Cowdin et al, 2009;Rajaraman et al, 2010;Custodio et al, 2011;Hu et al, 2011;Zhou et al, 2011;Liu et al, 2012;Luo et al, 2013;Pan et al, 2013;Wang et al, 2012;Xu et al, 2013).…”

Section: Research Articlementioning

confidence: 99%

Association between the XRCC1 Arg194Trp Polymorphism and Glioma Risk: an Updated Meta-analysis

Chen²,

Liu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Genetic polymorphisms in the DNA repair gene XRCC1 and susceptibility to glioma in a Han population in northeastern China: A case–control study

Cited by 22 publications

References 27 publications

Association Between Genetic Polymorphism of XRCC1 Gene and Risk of Glioma in а Chinese Population

Association Between Genetic Polymorphism of XRCC1 Gene and Risk of Glioma in а Chinese Population

Association of polymorphisms of the xeroderma pigmentosum complementation group F gene with increased glioma risk

Association between the XRCC1 Arg194Trp Polymorphism and Glioma Risk: an Updated Meta-analysis

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