2008
DOI: 10.4238/vol7-4gmr439
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Genetic polymorphisms in TLR4, CR1 and Duffy genes are not associated with malaria resistance in patients from Baixo Amazonas region, Brazil

Abstract: ABSTRACT. The main purpose of this research was to analyze the relation of the genetic polymorphisms frequently expressed by antigen-presenting cells, erythrocytes and malaria susceptibility/resistance with the human malaria infection cases. The sample used consisted of 23 Plasmodium vivax (Pv)-and P. falciparum (Pf)-infected patients, and 21 healthy individuals as a control group, from the Baixo Amazonas population in Pará, Brazil. The Asp299Gly polymorphisms in the Toll-like receptor 4 (TLR4), and Gly42Asp, … Show more

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Cited by 14 publications
(10 citation statements)
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“…No association was found between TLR-4 polymorphisms and mild malaria [22]. These results are in agreement with previous studies that found no association between TRL-4 and protection to mild malaria in a community in the Baixo Amazonas region in the state of Pará [20]. Recent studies have also shown a possible association between CR1-polymorphisms and susceptibility to P. falciparum infection in individuals from an endemic area in the state of Amazonas [21].…”
Section: Introductionsupporting
confidence: 90%
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“…No association was found between TLR-4 polymorphisms and mild malaria [22]. These results are in agreement with previous studies that found no association between TRL-4 and protection to mild malaria in a community in the Baixo Amazonas region in the state of Pará [20]. Recent studies have also shown a possible association between CR1-polymorphisms and susceptibility to P. falciparum infection in individuals from an endemic area in the state of Amazonas [21].…”
Section: Introductionsupporting
confidence: 90%
“…Recent studies have also shown a possible association between CR1-polymorphisms and susceptibility to P. falciparum infection in individuals from an endemic area in the state of Amazonas [21]. However, in the state of Pará, no correlation was observed between CR-1 with resistance to P. falciparum infections [20]. It has been reported that the regulation of IL-10 levels, an anti- inflammatory cytokine, in P. vivax infected patients may be unaltered by polymorphism in the promoter region of IL-10 gene [23].…”
Section: Introductionmentioning
confidence: 99%
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“…In Brazil, polymorphisms in TLR4 and TLR9 are described to be associated with malaria susceptibility and with increased parasitemia in P. falciparum infection or mixed infections 8,9,10 . These studies are not included in the meta-analysis presented in this issue.…”
mentioning
confidence: 99%