Genetic polymorphisms in TNF-α as a potential biomarker for oral health-related quality of life in children

Antunes, Leonardo Santos; Pinheiro, Liz Helena Moraes; Castilho, Thuanny; Todoroff, Nicolle; DUARTE, Camila; Tavares, Jhenyfer da Silva; Scariot, Rafaela; Küchler, Érika Calvano; Antunes, Leonardo Santos

doi:10.1590/1807-3107bor-2022.vol36.0059

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…Para-athletes who have experienced caries and possess the IL1A gene in a dominant model are significantly more likely to experience psychological discomfort than those with the alternate allele. 33 In this study, similar to a previous one that investigated the TNF-α gene as a biomarker for OHRQoL 35 , we hypothesized that OHRQoL in patients with dental caries is influenced by the individual's genetic background. Only children with untreated dental caries were included since the main goal of the present study was to investigate the role of these genes in the OHRQoL of affected children.…”

Section: Discussionmentioning

confidence: 89%

“…In dentistry, some emerging studies have suggested that an individual's genetic background interferes with the perception of OHRQoL, providing evidence of the association between genetic polymorphisms and OHRQoL. [31][32][33][34][35] In individuals requiring orthognathic surgery, depression, temporomandibular disorders, and genetic polymorphisms in the IL6 gene negatively impact OHRQoL. 32 Polymorphisms in the ANKK1 gene are associated with a positive impact in women who undergo orthognathic surgery 31 .…”

Section: Discussionmentioning

confidence: 99%

“…According to Antunes et al 35 , dentistry originally had a predominantly restorative orientation. Gradually, with the incorporation of the basic ideas and principles of preventive dentistry, the area has increasingly become holistic and incorporates an expanded view of the patient.…”

Section: Discussionmentioning

confidence: 99%

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Association of MTR and MTRR genes and oral health-related quality of life in children with dental caries

et al. 2023

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This study aimed to assess whether genetic polymorphisms in MTR and MTRR are potential biomarkers of oral health-related quality of life (OHRQoL) in children with caries. A cross-sectional study was designed wherein pairs of parents/caregivers and children (aged two-five years) were selected. Clinical examination was used to detect dental caries, which were classified as low-severity and high-severity caries. The Early Childhood Oral Health Impact Scale (ECOHIS) questionnaire was used to assess OHRQoL. Genomic DNA extracted from the saliva was used to analyze two missense genetic polymorphisms: MTR (rs1805087) and MTRR (rs1801394). Mann-Whitney non-parametric test was used to analyze candidate genes with OHRQoL scale and domain, with a significance level of p≤0.05. MTR (rs1805087) was found associated (p = 0.05) with children's OHRQoL subscale scores in the dominant model (GG + AG). Genetic polymorphisms in MTR may increase the risk of poor OHRQoL in children with caries. Further studies are needed to investigate genetics, molecular factors, and OHRQoL.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Association of MTR and MTRR genes and oral health-related quality of life in children with dental caries

et al. 2023

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“…Inducible nitric oxide (NOS2), through the metabolic pathway, can also be associated with HRQoL in the domain of emotional functioning (depression) 10 . In dental research, some studies have already reported the association between genetic polymorphisms and OHRQoL in patients with temporomandibular disorders 16 , dental caries 17 , 18 , open bite malocclusion 19 , and patients submitted to orthognathic surgery 20 .…”

Section: Introductionmentioning

confidence: 99%

Influence of genetic polymorphisms on oral health-related quality of life after root canal treatment

Queiroz,

Castilho,

Guimarães

et al. 2024

Braz. Dent. J.

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To evaluate the impact of genetic polymorphisms in interleukins (IL1A rs17561, rs1304037; IL10 rs1800871; IL1RN rs9005), nitric oxide (NOS2 rs2779249, rs2897518) and suppressor of cytokine signaling (SOCS1 rs243327, rs33977706) on oral health-related quality of life (OHRQoL) of patients under-going root canal treatment (RCT). Methods: The sample consisted of 108 participants, presenting single-rooted teeth with asymptomatic periapical periodontitis. The impact of the OHRQoL was recorded using the Oral Health Impact Profile (OHIP-14) before, seven, and 30 days after RCT. Saliva samples were collected as a source of genomic DNA. Genetic polymorphisms were genotyped by Real-Time PCR using the Taqman method. Univariate and Multivariate analyses were used (p<0.05). Results: A significant difference was observed for the polymorphism rs2297518 in the NOS2 gene in functional limitation in the codominant (p=0.037) and recessive (p=0.001) models; in the physical pain (p<0.001 in both models); in psychological discomfort (p<0.001 in both models); in physical disability (p<0.001 in both models) and in psychological disability (p<0.001 in both models). Polymorphisms in the SOCS1 gene, in the recessive model, rs33977706 (p=0.045) and rs243327 (p=0.019), influenced the OHRQoL in the psychological discomfort domain. Conclusions: Polymorphisms in NOS2 and SOCS1 genes influenced the OHRQoL of patients undergoing RCT.

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Impact of Tumor Necrosis Factor Alfa on Dental Caries Development in Children with Severe SNC Disorders

Spinei,

Plamadeala,

Balteanu

et al. 2023

IFMBE Proceedings

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Genetic polymorphisms in TNF-α as a potential biomarker for oral health-related quality of life in children

Cited by 5 publications

References 30 publications

Association of MTR and MTRR genes and oral health-related quality of life in children with dental caries

Association of MTR and MTRR genes and oral health-related quality of life in children with dental caries

Influence of genetic polymorphisms on oral health-related quality of life after root canal treatment

Impact of Tumor Necrosis Factor Alfa on Dental Caries Development in Children with Severe SNC Disorders

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