Genetic Polymorphisms of Ischemic Stroke in Asians

Besin, Valentinus; Yulianti, Trilis; Notopuro, Paulus Budiono; Humardani, Farizky Martriano

doi:10.1016/j.cca.2023.117527

Cited by 5 publications

(1 citation statement)

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“…Mishra et al have reported the existence of ancestry-specific stroke-associated loci in Europeans and East Asians, 4 and Besin et al have shown that genetic variants involved in various stages of stroke pathogenesis, such as the atherosclerosis pathway and transporter regulation (i.e., PON1 rs662 R allele, ALOX5AP rs10507391 T allele), have race-specific effects. 28 Therefore, the impact of these variants cannot be excluded in this retrospective observational study. Fortunately, according to the GBD study, about 90% of the disability-adjusted life-years are associated with modifiable risk factors, indicating that ample opportunities still exist to prevent stroke.…”

Section: Discussionmentioning

confidence: 98%

Racial Differences in Ischemic and Hemorrhagic Stroke: An Ecological Epidemiological Study

Kang,

Yang,

Kim

et al. 2024

Thromb Haemost

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Background: This study aimed to evaluate racial differences in the incidence of stroke by conducting an ecological epidemiological study using UK Biobank and Korean nationwide data. Methods: This study used patient-level data from the Korean National Health Insurance Service-Health Screening and UK Biobank, which included participants who underwent health examinations between 2006 and 2010. We included 112,750 East Asians (50.7% men, mean age 52.6 years) and 210,995 Caucasians (44.7% men, mean age 55.0 years) who were not diagnosed with atrial fibrillation, cardiovascular diseases, chronic kidney disease, chronic obstructive pulmonary disease, or cancer. The primary outcome was defined as a composite of ischemic and hemorrhagic stroke. Results: East Asians tended to have a lower body mass index (23.7 kg/m2 vs. 26.4 kg/m2, P < 0.001) and a higher proportion of participants who did not engage in moderate-to-vigorous physical activity (49.6% vs. 10.7%, P < 0.001) than Caucasians. During the follow-up, East Asians had higher five-year incidence rates (presented as per 1000 person-years) for primary outcome (1.73 vs. 0.50; incidence rate ratio [IRR] 3.48, 95% confidence interval [CI] 3.13–3.88), ischemic stroke (1.23 vs. 0.33; IRR 3.70, 95% CI 3.25–4.21), hemorrhagic stroke (0.56 vs. 0.18; IRR 3.20, 95% CI 2.67–3.84), and atrial fibrillation-related stroke (0.19 vs. 0.09; IRR 2.04, 95% CI 1.55–2.68). Conclusions: Based on this ecological epidemiological study, racial differences in stroke incidence were robust to a variety of statistical analyses, regardless of the subtype. This suggests the need for region-specific approaches to stroke prevention

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Section: Discussionmentioning

confidence: 98%