Genetic recombination and directional selection for DDT resistance in Drosophila melanogaster

Flexon, Phillip B.; Rodell, Charles F.

doi:10.1038/298672a0

Cited by 65 publications

(30 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our computer simulations fully con"rmed this expectation for all ranges of ss and r. In a temporally varying environment, selection on quantitative traits may lead to an advantage for sexual recombination (Maynard Smith, 1980, 1988aKorol & Preygol, 1989;Bergman & Feldman, 1990;Charlesworth, 1993;Kondrashov & Yampolsky, 1996;Otto & Michalakis, 1998). There is evidence from arti"cial selection experiments that a response to the directional selection on a trait is frequently associated with a correlated increase in the recombination rate (Flexon & Rodell, 1982;Gorodetsky et al, 1990;Korol & Iliadi, 1994;Korol, 1999). In our model with the mixed breeding system, we found that in the cyclical varying environment, weak #uctuating selection did not make mixing advantageous (in terms of mean "tness).…”

Section: What Causes the Advantages Or Disadvantages Of Sex? Segregatsupporting

confidence: 66%

Polymorphism Maintenance in Populations with Mixed Random Mating and Apomixis Subjected to Stabilizing and Cyclical Selection

Ryndin

Kirzhner

Nevo

et al. 2001

Journal of Theoretical Biology

View full text Add to dashboard Cite

Section: What Causes the Advantages Or Disadvantages Of Sex? Segregatsupporting

confidence: 66%

Polymorphism Maintenance in Populations with Mixed Random Mating and Apomixis Subjected to Stabilizing and Cyclical Selection

Ryndin

Kirzhner

Nevo

et al. 2001

Journal of Theoretical Biology

View full text Add to dashboard Cite

“…This has been verified in a number of empirical studies (eg Harinarayana and Murty, 1971;Flexon and Rodell, 1982;Zhuchenko et al, 1985;Burt and Bell, 1987;Wolf et al, 1987;Korol and Iliadi, 1994). The reverse predictionthat is that manipulating the level of recombination should result in changes in the response to selectionhas received some attention to date, with contradictory results (Carson, 1958;McPhee and Robertson, 1970;Markow, 1975;Malmberg, 1977;Thompson, 1977;Zeyl and Bell, 1997;Rice and Chippendale, 2001).…”

Section: Introductionmentioning

confidence: 96%

Genetic recombination and adaptation to fluctuating environments: selection for geotaxis in Drosophila melanogaster

et al. 2003

View full text Add to dashboard Cite

Heritable variation in fitness is the fuel of adaptive evolution, and sex can generate new adaptive combinations of alleles. If the generation of beneficial combinations drives the evolution of recombination, then the level of recombination should result in changes in the response to selection. Three types of lines of Drosophila melanogaster varying in their level of genetic recombination were selected over 38 generations for geotaxis. The within-chromosome recombination level of these lines was controlled for 60% of the genome: chromosome X and chromosome II. The full recombination lines had normal, unmanipulated levels of recombination on these two chromosomes. Conversely, nonrecombination lines had recombination effectively eliminated within the X and second chromosomes. Finally, partial recombination lines had the effective rate of within-chromosome recombination lowered to 10% of natural levels for these two chromosomes. The rate of response to selection was measured for continuous negative geotaxis and for a fluctuating environment (alternating selection for negative and positive geotaxis). All selected Drosophila lines responded to selection and approximately 36% of the response to selection was because of the X and second chromosomes. However, recombination did not accelerate adaptation during either directional or fluctuating selection for geotaxis.

show abstract

“…Lond. B (2003) theoretical analysis have shown that directional selection, in combination with nite population size and/or spatial heterogeneity, may promote a selective advantage of increased recombination under much less restrictive assumptions than usually thought (Flexon & Rodell 1982;Gorodetski et al 1990;Korol & Iliadi 1994;Otto & Barton 1997;Korol 1999;Lenormand & Otto 2000). Assuming that sex helps organisms to adapt to adverse conditions, one can further propose that in natural populations of fungi the abundance of sexual forms will be positively correlated with the severity of stress.…”

Section: The Hypothesismentioning

confidence: 99%

Ecological stress and sex evolution in soil microfungi

Grishkan

Korol

Nevo

et al. 2003

Proc. R. Soc. Lond. B

View full text Add to dashboard Cite

The elucidation of the origin and maintenance of sex is a major unsolved problem in evolutionary biology. A number of hypotheses have been elaborated, but the scarcity of empirical data limits further progress. During recent years, the general inclination has changed towards pluralistic models of sex evolution, due partly to an increased diversity of studied organisms. Fungi are among the most promising organisms for testing sexual causation, as demonstrated in recent laboratory experiments. However, reconciling theory and evidence necessitates critical eld observations. Here, we report new estimates of the distribution of morphologically sexual and asexual soil microfungi in nature, which indicate a remarkable trend towards increased sexuality with increasing climatic stress.

show abstract

Genetic recombination and directional selection for DDT resistance in Drosophila melanogaster

Cited by 65 publications

References 14 publications

Polymorphism Maintenance in Populations with Mixed Random Mating and Apomixis Subjected to Stabilizing and Cyclical Selection

Polymorphism Maintenance in Populations with Mixed Random Mating and Apomixis Subjected to Stabilizing and Cyclical Selection

Genetic recombination and adaptation to fluctuating environments: selection for geotaxis in Drosophila melanogaster

Ecological stress and sex evolution in soil microfungi

Contact Info

Product

Resources

About