Genetic risks caused by occupational chemicals. Use of experimental methods and occupational risk group monitoring in the detection of environmental chemicals causing mutations, cancer and malformations.

Hemminki, Kari; Sorsa, Marja; Vainio, Harri

doi:10.5271/sjweh.2651

Cited by 56 publications

(6 citation statements)

References 39 publications

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“…Studies have shown that chemicals play an important role in the etiology of several kinds of human cancers [4, 5]. It is well-known that exposure to various hazardous chemicals occurs at very low doses, extends through longer time period of life and influence great part of population [6]. Tumor induction in workers exposed to coal tar in 1775 was the earliest known instance of environmental carcinogenesis documented.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and hepatoprotective potential of Lawsonia inermis L. leaves against 2-acetylaminofluorene induced hepatic damage in male Wistar rats

Kumar

Kaur

Chandel

et al. 2017

BMC Complement Altern Med

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Background Lawsonia inermis (Lythraceae) is an ethnomedicinal plant, traditionally known for curing several ailments such as skin diseases, bacterial infections, jaundice, renal lithiases and inflammation etc. The present work deals with assessment of in vitro antioxidant and in vivo hepatoprotective potential of butanolic fraction (But-LI) of Lawsonia inermis L. leaves.MethodsAntioxidant activity was evaluated using deoxyribose degradation, lipid peroxidation inhibition and ferric reducing antioxidant power (FRAP) assay. In vivo protective potential of But-LI was assessed at 3 doses [100, 200 & 400 mg/kg body weight (bw)] against 2-acetylaminofluorene (2-AAF) induced hepatic damage in male Wistar rats.ResultsBut-LI effectively scavenged hydroxyl radicals in deoxyribose degradation assay (IC50 149.12 μg/ml). Fraction also inhibited lipid peroxidation and demonstrated appreciable reducing potential in FRAP assay. Treatment of animals with 2-AAF resulted in increased hepatic parameters such as SGOT (2.22 fold), SGPT (1.72 fold), ALP (5.68 fold) and lipid peroxidation (2.94 fold). Different concentration of But-LI demonstrated pronounced protective effects via decreasing levels of SGOT, SGPT, ALP and lipid peroxidation altered by 2-AAF treatment. But-LI administration also restored the normal liver architecture as evident from histopathological studies.ConclusionsThe present experimental findings revealed that phytoconstituents of Lawsonia inermis L. possess potential to effectively protect rats from the 2-AAF induced hepatic damage in vivo possibly by inhibition of reactive oxygen species and lipid peroxidation.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and hepatoprotective potential of Lawsonia inermis L. leaves against 2-acetylaminofluorene induced hepatic damage in male Wistar rats

Kumar

Kaur

Chandel

et al. 2017

BMC Complement Altern Med

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“…Some particular agents, esp eciall y me t ho trexate, have been shown to be teratogenic in pr eg nant women being treated by cancer chemotherapy (3,4). Moreover the re lat ionship between the mec ha nisms of mutagenesis and teratogenesis have been emphasized by several authors (5,6) .…”

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Risk of spontaneous abortion among nurses handling antineoplastic drugs.

Stücker¹,

Caillard²,

Collin³

et al. 1990

Scand J Work Environ Health

129

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of spontaneous abortion among nurses hand ling antineo plastic drugs. Scand J Work Environ Health 1990;16:102-7 . The purpo se of the study was to evaluate the frequency of spontaneous abortion in two groups of women. One group consisted of women regularly involved in the preparation of cancer chemothe rapy perfusions and therefore considered to be exposed to cytostatic agents; the other consisted of women not occupationally exposed to such agents. The study was carried out in four French hospitals. Four hundred and sixty-six women were involved; 534 pregnancies were described in which 139 were exposed and 357 were unexposed . The results showed that the frequency of spontaneous abortion was 26 % for the exposed pregnancies and 15 070 in the unexposed ones (odds ratio 2.0). These results do not seem to be due either to the classic risk factors of spontaneous abortion (age, cigarette consumption duri ng pregnancy, pregnancy order) (adjusted odd s ratio I.7) or to possible errors concerning the retrospective evaluation of prior gynecologic and obstetric history.

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“…Los agentes citostáticos o fármacos antineoplásicos se utilizan cada vez más en el tratamiento de muchas enfermedades y en especial de aquellas relacionadas con el cáncer, estos fármacos no sólo afectan a las células tumorales sino también a todas las células del organismo. Los datos de la Agencia Internacional para la Investigación del Cáncer y diversos estudios sobre su tratamiento, han mostrado suficiente evidencia científica para determinar los efectos carcinogénicos, mutagénicos y teratogénicos de muchos de estos agentes citostáticos en seres humanos [1][2][3] .…”

Section: Introductionunclassified

Manejo de citostáticos y salud reproductiva: revisión bibliográfica

2013

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ResumenIntroducción: La utilización de agentes citostáticos ha mostrado suficiente evidencia científica en el origen de efectos carcinogénicos, mutagénicos y teratogénicos en seres humanos. El riesgo de exposición a estos agentes no se limita esencialmente a las personas que reciben dosis terapéuticas, también existe importante riesgo de exposición sobre la salud de los trabajadores que participan en la preparación, manipulación, administración y almacenamiento de estos medicamentos.Objetivo general: Revisar la literatura científica para establecer la relación entre el manejo de citostáticos por el personal sanitario y los posibles efectos sobre la salud reproductiva. Material y Métodos:Se realizó una revisión de la literatura existente a partir del año 2005 hasta el año 2012. La búsqueda se realizó por consulta directa y acceso por internet a la literatura recogida en las bases de datos de MEDLINE. Al introducir los filtros se obtuvo un total de 5 publicaciones de evidencia científica, las cuales fueron analizadas.Resultados: En un meta-análisis de 2005 se encontraron datos de abortos espontáneos, fetos muertos, malformaciones congénitas, embarazos ectópicos y cáncer. En un estudio posterior de casos y control se encontraron datos de partos prematuros, bajo peso al nacer y dificultades para conseguir la concepción. En los estudios de cohortes se encontró evidencia de: en uno, de abortos espontáneos; en otro de malformaciones congénitas y cáncer y en otro se encontraron datos de bajo peso al nacer y anomalías congénitas, pero con menores cifras de lo esperado.Discusión/Conclusiones: Los resultados encontrados no muestran una asociación estadística significativa, y por lo tanto sería de utilidad realizar estudios más potentes. A pesar de la existencia de Guías y Protocolos desde 2004, estudios posteriores a 2005 siguen evidenciando riesgos y efectos relacionados con la exposición, por lo tanto existe un margen para mejorar la evaluación del cumplimiento de dichos protocolos. A su vez existe rango de mejora en el campo de Vigilancia de la Salud.Med Segur Trab (Internet) 2013; 59 (233) 426-443 Palabras clave: Citostáticos, salud reproductiva, efectos mutagénicos, carcinogénicos y teratogénicos.Octubre -diciembre 2013Med Segur Trab (Internet) 2013; 59 (233) 426-443Manejo de citostáticos y salud reproductiva: revisión bibliográfica Abstract Introduction: The use of cytostatic agents has shown enough scientific evidence in the origin of mutagenic and cancer effects, as well as teratogenicity in human beings. The risk of exposure to these agents is not only confined to patients receiving therapeutic doses, but also there is an important exposure risk on the health of workers participating in the preparation, handling, administration and storage of these agents.General Objective: To review current literature in order to establish the relationship between cytostatic handling by health workers, and the possible effects on reproductive health. Material and Methods:A literature review between 2005 to 2012 was carried out....

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Genetic risks caused by occupational chemicals. Use of experimental methods and occupational risk group monitoring in the detection of environmental chemicals causing mutations, cancer and malformations.

Cited by 56 publications

References 39 publications

Antioxidant and hepatoprotective potential of Lawsonia inermis L. leaves against 2-acetylaminofluorene induced hepatic damage in male Wistar rats

Antioxidant and hepatoprotective potential of Lawsonia inermis L. leaves against 2-acetylaminofluorene induced hepatic damage in male Wistar rats

Risk of spontaneous abortion among nurses handling antineoplastic drugs.

Manejo de citostáticos y salud reproductiva: revisión bibliográfica

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