2015
DOI: 10.4238/2015.december.8.7
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Genetic screening and evaluation for chromosomal abnormalities of infertile males in Jilin Province, China

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Cited by 16 publications
(20 citation statements)
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“…The deletion of AZFc region was the most commonly type of microdeletion of AZF region (Li et al., ), and the microdeletion of AZFc region was detected in five cases in our study. Otherwise, AZFd deletions might be present with mild oligospermia or normal sperm counts with an abnormal sperm morphology such as a severe teratozoospermia phenotype (Zhang et al., ). Interestingly, we found one case with microdeletion in the AZFd region as well as SCOS.…”
Section: Discussionmentioning
confidence: 99%
“…The deletion of AZFc region was the most commonly type of microdeletion of AZF region (Li et al., ), and the microdeletion of AZFc region was detected in five cases in our study. Otherwise, AZFd deletions might be present with mild oligospermia or normal sperm counts with an abnormal sperm morphology such as a severe teratozoospermia phenotype (Zhang et al., ). Interestingly, we found one case with microdeletion in the AZFd region as well as SCOS.…”
Section: Discussionmentioning
confidence: 99%
“…Carriers of reciprocal translocations, while phenotypically normal, may experience reduced fertility and spontaneous abortions (Harton and Tempest, 2012). Previous studies have reported the involvement of balanced reciprocal translocations on chromosome 7 in male infertility and recurrent miscarriage (Tharapel et al, 1985;Vozdova et al, 2013;Zhang et al, 2015c). In the current investigation, reciprocal translocation was identified in 82 (1.57%) infertile men, 14 of whom (17.07%) carried chromosome 7 translocations.…”
Section: Discussionmentioning
confidence: 99%
“…These effects are dependent on the specific chromosomes involved in the translocation, the locations of the breaks, and the frequency of chiasmata (Vozdova et al, 2008;Harton and Tempest, 2012;Godo et al, 2013). Previous reports have indicated the involvement of balanced reciprocal translocations of chromosome 7 in male infertility and recurrent miscarriage (Tharapel et al, 1985;Vozdova et al, 2013;Zhang et al, 2015c).…”
Section: Introductionmentioning
confidence: 99%
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