Genetic Studies among the Endogamous Groups of Lohanas of North and West India

Abstract

Four groups of Lohanas, belonging to the Gujarati, Sindhi and Punjabi were studied for various genetic markers. Lohanas have higher B than A and low Rh(D) negative (1.65–4.64%). The Hp¹ gene ranges from 0.1557 to 0.2639; Gm¹ is lower (0.34–0.55) than in other populations in Southern India. G-6-PD deficiency was prevalent in 3–8%. All the four groups have a high incidence of the thalassaemia trait and possess Hb-D. Hb, J, and L were also observed in two groups. Data was analysed for intergroup differences.

Hemoglobinopathies in South Gujarat population and incidence of anemia in them

“…Cutchhi, Halai and Sindhi Lohanas have been studied by Bhatia et al . [3] and 10.7%, 17.2% and 6.8% prevalence of BTT respectively has been reported in them. Mulchndani et al .…”

“…Several studies in the literature have reported that Gujarat has higher frequency of β-thalassemia and sickle cell disease. [34910] Therefore prospective studies are essential to identify high risk communities. Premarital screening of college students not only gives prevalence in different caste groups but also helps in counseling and prenatal diagnosis programs for prevention of birth of an affected child.…”

“…[2] Several studies have revealed high prevalence of beta thalassemia trait (BTT) in some caste groups in Gujarat. [3–4] Abnormal hemoglobins D, J and L have been reported in Cutchi Lohana community of Gujarat. [3] Certain castes and tribes in Gujarat are yet to be investigated for β-thalassemia and other abnormal hemoglobins.…”

“…[3–4] Abnormal hemoglobins D, J and L have been reported in Cutchi Lohana community of Gujarat. [3] Certain castes and tribes in Gujarat are yet to be investigated for β-thalassemia and other abnormal hemoglobins.…”

Study of prevalence of hemoglobinopathy in Sindhi community of Jamnagar, Gujarat: A pilot study

“…Several studies in the literature have reported that Gujarat has a higher frequency of betathalassemia and sickle cell disease. [8][9][10][11] In our pilot study, the overall prevalence of hemoglobinopathies in Sindhi community is 19.26%. Prevalence of BTT is 15.59%, which is an accordance with other study done by Sukumaran [11][12][13][14][15] [ Table 4].…”