Genetic study of 15 STRs loci of Identifiler system in Angola population

Melo, Miguel Manuel; Carvalho, M.; Lopes, V.; Anjos, M.J.; Serra, A.; Vieira, Duarte Nuno; Sequeiros, Jorge; Côrte-Real, F.

doi:10.1016/j.fsigen.2010.03.010

Cited by 16 publications

(5 citation statements)

References 15 publications

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“…In order to estimate the genetic affiliations, we constructed a database including 73 populations (71,388 individuals in total) (Ali et al, 2012; Alves et al, 2014; Andreassen, Pereira, Dupuy, & Mevaag, 2010; Bernal et al, 2006; Bindu, Trivedi, & Kashyap, 2007; Calzada et al, 2005; Cardoso, Sevillano, Illescas, & de Pancorbo, 2016; Coudray, Calderon, et al, 2007; Coudray, Guitard, el‐Chennawi, Larrouy, & Dugoujon, 2007; Coudray, Guitard, Keyser‐Tracqui, et al, 2007; Decorte et al, 2004; Gehrig et al, 2014; Gurkan, Demirdov, Yamaci, & Sevay, 2015; Havas, Jeran, Efremovska, Dordevic, & Rudan, 2007; Hedjazi, Nikbakht, Hosseini, Hoseinzadeh, & Hosseini, 2013; Jemeljanova et al, 2015; Jin et al, 2017; Jingzhou Wang et al, 2015; Khodjet‐el‐Khil et al, 2012; Kraaijenbrink, van Driem, Opgenort, Tuladhar, & de Knijff, 2007; Kraaijenbrink, van Driem, et al, 2007; Le Wang et al, 2013; Li et al, 2015, 2017, 2018, 2020; Liao et al, 2019; Lili Zhang et al, 2017; Liu, Liu, & Wang, 2006a, 2006b; Liu, Chen, Huang, et al, 2017; Liu, Chen, Mei, et al, 2017; Lopes et al, 2009; Maruyama, Minaguchi, Takezaki, & Nambiar, 2008; Melo et al, 2010; Meng Pan et al, 2012; Munoz, Pinto de Erazo, Baeza, Arroyo‐Pardo, & Lopez‐Parra, 2015; Muro et al, 2008; Okolie et al, 2018; Petric, Draskovic, Zgonjanin‐Bosic, Budakov, & Veselinovic, 2012; Qiuling Liu et al, 2003; Rodriguez, Salvador, Calacal, Laude, & De Ungria, 2015; Sadam et al, 2015; Serga et al, 2017; Shan et al, 2016; Shen et al, 2015; Shotivaranon, Chirachariyavej, Leetrakool, & Rerkamnuaychoke, 2009; Soltyszewski et al, 2014; Steinlec...…”

Section: Resultsmentioning

confidence: 99%

RETRACTED: Forensic characteristics and phylogenetic analyses of one branch of Tai‐Kadai language‐speaking Hainan Hlai (Ha Hlai) via 23 autosomal STRs included in the Huaxia^™ Platinum System

Wang

et al. 2020

Molec Gen & Gen Med

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Section: Resultsmentioning

confidence: 99%

RETRACTED: Forensic characteristics and phylogenetic analyses of one branch of Tai‐Kadai language‐speaking Hainan Hlai (Ha Hlai) via 23 autosomal STRs included in the Huaxia^™ Platinum System

Wang

et al. 2020

Molec Gen & Gen Med

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“…Looking at the values of the power of discrimination, all 22 STR loci may be promising markers for paternity testing (PD between 0.973 and 0.993). One of the four probability tests showing signi cant departures from the HWE equilibrium (CSFPO locus) was also signi cant in Rwandans (Hutu) and Angolans [13,14]. The frequency of homozygotes at the CSFPO locus (9/33 = 27%) seems to indicate, as in Rwandans, that this deviation is due to homozygote excess [13].…”

Section: Discussionmentioning

confidence: 87%

New data on Short Tandem Repeat loci in Gabonese population: Tri-Allelic Patterns of Penta D and TPOX Identified

LENDOYE,

MOMBO,

MEZUI-MBENG

et al. 2023

Preprint

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Short tandem repeats (STRs) are repeating DNA sequences used in forensic human identity testing and the diagnosis of aneuploidies. Many STRs like Penta D and TPOX are used routinely for paternity tests, but these tests are not widely used in sub-Saharan Africa. The study population consisted of Gabonese families seeking a paternity test. After DNA extraction from the individuals collected by buccal swabs, we genotyped samples using a panel of 15 to 22 STRs. A total of 115 subjects from 39 families were included. Allele frequencies of the 22 STR loci were determined in unrelated Gabonese subjects. The most polymorphic loci were D21S11 and FGA, with 16 and 17 alleles, respectively, while D3S1358 and TH01 loci were less polymorphic, with 5 alleles. Deviations from Hardy-Weinberg equilibrium were only observed in the cases of TPOX, D3S1358, CSFPO and D7S820 loci. We report tri-allelic patterns that indicate aneuploidies at a combined frequency of 4% (4/115) with 3% for Penta D (1/35) and 3% for TPOX (3/102). Furthermore, we identified a new tri-allelic genotype 5-8-16 for the Penta D locus located on chromosome 21 in a healthy subject. In addition, we observed 3 tri-allelic variants of TPOX, located on chromosome 2, in healthy subjects, namely 8-10-11, 8-9-10, and 8-8-10. Our study revealed unsuspected polymorphic genetic mutations for the first time in Gabon that raise several questions about chromosomal disorders. Further population genetic studies are needed in Gabon to characterize these changes better, both qualitatively and quantitatively.

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“…39 also detected departure from HWE for D19S433 in San populations of South Africa. The CSF1PO locus was also seen to deviate from HWE in populations from Uganda (Karamoja) 35 and Angola 37 .…”

Section: Resultsmentioning

confidence: 97%

Genetic variation and population structure of Botswana populations as identified with AmpFLSTR Identifiler short tandem repeat (STR) loci

Tau

Wally²,

Fanie³

et al. 2017

Sci Rep

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Population structure was investigated in 990 Botswana individuals according to ethno-linguistics, Bantu and Khoisan, and geography (the nine administrative districts) using the Identifiler autosomal microsatellite markers. Genetic diversity and forensic parameters were calculated for the overall population, and according to ethno-linguistics and geography. The overall combined power of exclusion (CPE) was 0.9999965412 and the combined match probability 6,28 × 10−19. CPE was highest for the Khoisan Tuu ethnolinguistic group and the Northeast District at 0.9999582029 and 0.9999922652 respectively. CMP ranged from 6.28 × 10−19 (Khoisan Tuu) to 1,02 × 10−18 (Northwest district). Using pairwise genetic distances (FST), analysis of molecular variance (AMOVA), factorial correspondence analysis (FCA), and the unsupervised Bayesian clustering method found in STRUCTURE and TESS, ethno-linguistics were found to have a greater influence on population structure than geography. FCA showed clustering between Bantu and Khoisan, and within the Bantu. This Bantu sub-structuring was not seen with STRUCTURE and TESS, which detected clustering only between Bantu and Khoisan. The patterns of population structure revealed highlight the need for regional reference databases that include ethno-linguistic and geographic location information. These markers have important potential for bio-anthropological studies as well as for forensic applications.

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Genetic study of 15 STRs loci of Identifiler system in Angola population

Cited by 16 publications

References 15 publications

RETRACTED: Forensic characteristics and phylogenetic analyses of one branch of Tai‐Kadai language‐speaking Hainan Hlai (Ha Hlai) via 23 autosomal STRs included in the Huaxia^™ Platinum System

RETRACTED: Forensic characteristics and phylogenetic analyses of one branch of Tai‐Kadai language‐speaking Hainan Hlai (Ha Hlai) via 23 autosomal STRs included in the Huaxia^™ Platinum System

New data on Short Tandem Repeat loci in Gabonese population: Tri-Allelic Patterns of Penta D and TPOX Identified

Genetic variation and population structure of Botswana populations as identified with AmpFLSTR Identifiler short tandem repeat (STR) loci

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Genetic study of 15 STRs loci of Identifiler system in Angola population

Cited by 16 publications

References 15 publications

RETRACTED: Forensic characteristics and phylogenetic analyses of one branch of Tai‐Kadai language‐speaking Hainan Hlai (Ha Hlai) via 23 autosomal STRs included in the Huaxia™ Platinum System

RETRACTED: Forensic characteristics and phylogenetic analyses of one branch of Tai‐Kadai language‐speaking Hainan Hlai (Ha Hlai) via 23 autosomal STRs included in the Huaxia™ Platinum System

New data on Short Tandem Repeat loci in Gabonese population: Tri-Allelic Patterns of Penta D and TPOX Identified

Genetic variation and population structure of Botswana populations as identified with AmpFLSTR Identifiler short tandem repeat (STR) loci

Contact Info

Product

Resources

About

RETRACTED: Forensic characteristics and phylogenetic analyses of one branch of Tai‐Kadai language‐speaking Hainan Hlai (Ha Hlai) via 23 autosomal STRs included in the Huaxia^™ Platinum System

RETRACTED: Forensic characteristics and phylogenetic analyses of one branch of Tai‐Kadai language‐speaking Hainan Hlai (Ha Hlai) via 23 autosomal STRs included in the Huaxia^™ Platinum System