Genetic Tools for Studying the Roles of Sphingolipids in Viral Infections

Guzman, Gaelen; Creek, Cameron; Farley, Scotland; Tafesse, Fikadu G.

doi:10.1007/978-1-0716-2895-9_1

Cited by 2 publications

(1 citation statement)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, this did not occur when a heat-inactivated virus was investigated. More thorough reviews of the viral response to sphingolipids have been published [ 337 , 344 , 345 , 346 ], and although much remains to be discovered, the targeting of host cell sphingolipid metabolism to limit viral adhesion, entry, trafficking, and replication within host cells may offer exciting future therapeutic avenues of exploitation to aid in addressing the challenges associated with orthopedic PJI.…”

Section: Sphingolipids Viral Host Cell Entry and Orthopedic Infectionmentioning

confidence: 99%

Sphingolipid-Induced Bone Regulation and Its Emerging Role in Dysfunction Due to Disease and Infection

Seal,

Hughes,

Wei

et al. 2024

IJMS

View full text Add to dashboard Cite

The human skeleton is a metabolically active system that is constantly regenerating via the tightly regulated and highly coordinated processes of bone resorption and formation. Emerging evidence reveals fascinating new insights into the role of sphingolipids, including sphingomyelin, sphingosine, ceramide, and sphingosine-1-phosphate, in bone homeostasis. Sphingolipids are a major class of highly bioactive lipids able to activate distinct protein targets including, lipases, phosphatases, and kinases, thereby conferring distinct cellular functions beyond energy metabolism. Lipids are known to contribute to the progression of chronic inflammation, and notably, an increase in bone marrow adiposity parallel to elevated bone loss is observed in most pathological bone conditions, including aging, rheumatoid arthritis, osteoarthritis, and osteomyelitis. Of the numerous classes of lipids that form, sphingolipids are considered among the most deleterious. This review highlights the important primary role of sphingolipids in bone homeostasis and how dysregulation of these bioactive metabolites appears central to many chronic bone-related diseases. Further, their contribution to the invasion, virulence, and colonization of both viral and bacterial host cell infections is also discussed. Many unmet clinical needs remain, and data to date suggest the future use of sphingolipid-targeted therapy to regulate bone dysfunction due to a variety of diseases or infection are highly promising. However, deciphering the biochemical and molecular mechanisms of this diverse and extremely complex sphingolipidome, both in terms of bone health and disease, is considered the next frontier in the field.

show abstract