Genetic Variability in E6 and E7 Oncogenes from Human Papillomavirus Type 58 in Mexican Women

Conde-Ferráez, Laura; Pacheco-Arjona, José Ramón; Canul, Cinthia Novelo; Gómez-Carballo, Jesús; Ramírez-Prado, Jorge Humberto; Ayora-Talavera, Guadalupe; González-Losa, Marı́a del Refugio

doi:10.1159/000489306

Cited by 8 publications

(11 citation statements)

References 32 publications

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“…In contrast, this genotype was not found in any CC sample. The fact that PGMY amplification-based tests could not detect this genotype may be due to the variability reported for this genotype in Mexico and in some regions of the world (Raiol et al, 2009;Yue et al, 2013;Chen et al, 2016;Conde-Ferraez et al, 2017). HPVs 30, 214, and 11 were also common in this group.…”

Section: Discussionmentioning

confidence: 88%

Detection of Alpha, Beta, Gamma, and Unclassified Human Papillomaviruses in Cervical Cancer Samples From Mexican Women

Flores-Miramontes

Olszewski

Artaza‐Irigaray

et al. 2020

Front. Cell. Infect. Microbiol.

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Background: Cervical cancer (CC) is associated to high-risk human papillomavirus (HPV) infections, for this reason it is crucial to have sensitive and accurate HPV diagnostic tests. To date, most research is focused on HPVs within the Alphapapillomavirus (α-PVs) genus and little attention has been paid to cervical infections with other HPV genotypes, like those of the Betapapillomavirus (β-PVs) and Gammapapillomavirus (γ-PVs) genera. The aim of this study was to determine the HPV genotypes from different genera in women with CC using Next-Generation Sequencing (NGS). Methods: The study comprised 48 HPV positive CC samples evaluated with the Linear Array HPV Genotyping test and individually sequenced by 454 NGS using PGMY09/11 and FAP primers. To determine the HPV genotypes present in each sample, the obtained sequences were compared with all HPV L1 gene reference sequences from the Papillomavirus Episteme database (PaVE). Moreover, 50 HPV positive low-grade cervical lesion samples individually genotyped with NGS were also included to determine the genotypes present preferentially in CC patients.

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Section: Discussionmentioning

confidence: 88%

Detection of Alpha, Beta, Gamma, and Unclassified Human Papillomaviruses in Cervical Cancer Samples From Mexican Women

Flores-Miramontes

Olszewski

Artaza‐Irigaray

et al. 2020

Front. Cell. Infect. Microbiol.

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“…The most common synomous mutations observed in HPV58 E6 and E7 gene were C307T and T744G, which had also been reported in the past [44][45][46] . The C307T and T744G mutations were also common in other countries, such as Mexico, Korean and Italy 35,[47][48][49] . However, the variations included in the present study had been reported to have no association with cervical lesions 34,35,49 .…”

Section: Discussionmentioning

confidence: 95%

Characteristics of human papillomavirus infection among females and the genetic variations of HPV18 and HPV58 in Henan province, China

Wang

Han

Wang

et al. 2023

Sci Rep

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The present study aims to investigate the genotype distribution of Human papillomavirus (HPV) and variations of HPV18 and HPV58 infection among 6538 females in Luoyang city during 2019–2021. The overall positive rate of females with HPV infection was 12.34%, with 9.74% were infected with single HPV and 2.60% with multiple HPVs. The prevalent rate of high-risk HPV (HR-HPV) was 9.85% and the top five HR-HPV genotypes were HPV52 (1.94%), HPV16 (1.93%), HPV58 (1.48%), HPV51 (1.02%) and HPVV39 (0.99%). Two peaks of HPV infections rates were observed in females aged ≤ 20 and 61–65 years old. To characterize mutations, 39 HPV18 and 56 HPV58 L1, E6 and E7 genes were sequenced and submitted to GenBank. In the HPV18 E6-E7-L1 sequences, 38 nucleotides changes were observed with 10/38 were non-synonymous mutations (5 in E6 gene, 1 in E7 gene and 4 in L1 gene). In the HPV58 E6-E7-L1 sequences, 53 nucleotides changes were observed with 23/53 were non-synonymous mutations (3 in E6 gene, 5 in E7 gene and 15 in L1 gene). Phylogenetic analysis based on L1 gene showed that 92.3% (36/39) of HPV18 isolates fell into sublineage A1 and 7.7% (3/39) belonged to A5. For HPV58, 75.0% (42/56) isolates belonged to sublineage A1 and 25.0% (14/56) were sublineage A2. There was no association between amino mutation and cervical lesions. The present study provides basic information about the distribution, genotypes and variations of HPV among females population in Luoyang city, which would assist in the formulation of HPV screening and vaccination programs and preventive strategies for HPV-attributable cancer in this region.

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“…It’s worth mentioning that intratype variants of HPV types 31, 35, 62, and 58 have been also characterized from cervical samples of Mexican women from different states of Mexico [ 97 , 100 , 101 ]. Additionally, variations in HPV-51 have been analyzed in HIV positive Mexican patients, this viral type being highly prevalent in this group [ 102 ].…”

Section: Distribution Of Hpv Variants In Mexicomentioning

confidence: 99%

Epidemiology and Molecular Biology of HPV Variants in Cervical Cancer: The State of the Art in Mexico

Muñoz-Bello

Carrillo-García

Lizano

2022

IJMS

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Cervical cancer (CC) continues to be a major public health problem in Mexico, ranking second among cancers in women. A persistent infection with human papillomaviruses (HPV) is the main risk factor for CC development. In addition, a significant fraction of other cancers including those of the anus, oropharynx, and penis are also related to HPV infection. In CC, HPV-16 is the most prevalent high-risk HPV type, followed by HPV-18, both being responsible for 70% of cases. HPV intratype variant lineages differ in nucleotide sequences by 1–10%, while sublineages differ by 0.5–1%. Several studies have postulated that the nucleotide changes that occur between HPV intratype variants are reflected in functional differences and in pathogenicity. Moreover, it has been demonstrated that HPV-16 and -18 intratype variants differentially affect molecular processes in infected cells, changing their biological behavior that finally impacts in the clinical outcome of patients. Mexico has participated in providing knowledge on the geographical distribution of intratype variants of the most prevalent HPVs in premalignant lesions of the cervix and cervical cancer, as well as in other HPV-related tumors. In addition, functional studies have been carried out to assess the cellular effects of intratype variations in HPV proteins. This review addresses the state of the art on the epidemiology of HPV-16 and HPV-18 intratype variants in the Mexican population, as well as their association with persistence, precancer and cervical cancer, and functional aspects related to their biological behavior.

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Genetic Variability in E6 and E7 Oncogenes from Human Papillomavirus Type 58 in Mexican Women

Cited by 8 publications

References 32 publications

Detection of Alpha, Beta, Gamma, and Unclassified Human Papillomaviruses in Cervical Cancer Samples From Mexican Women

Detection of Alpha, Beta, Gamma, and Unclassified Human Papillomaviruses in Cervical Cancer Samples From Mexican Women

Characteristics of human papillomavirus infection among females and the genetic variations of HPV18 and HPV58 in Henan province, China

Epidemiology and Molecular Biology of HPV Variants in Cervical Cancer: The State of the Art in Mexico

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