Genetic Variants and Haplotypes in <i>OPG</i> Gene Are Associated with Premature Coronary Artery Disease and Traditional Cardiovascular Risk Factors in Mexican Population: The GEA Study

Pérez-Hernández, Nonanzit; Posadas-Sánchez, Rosalinda; Vargas‐Alarcón, Gilberto; Cazarín-Santos, Benny Giovanni; Miranda‐Duarte, Antonio; Rodrı́guez-Pérez, José Manuel

doi:10.1089/dna.2020.5949

Cited by 5 publications

(4 citation statements)

References 62 publications

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“…Nevertheless, the participation of rs3102735 as a susceptibility marker is still under debate. Even if this polymorphism has been shown to be associated with the incidence of diseases other than cardiovascular diseases [ 8 , 28 , 29 ], a lack of association with the incidence of symptomatic CAD [ 30 ] or large artery atherosclerosis stroke [ 28 ] has been reported. The topography of atherosclerotic lesions as well as the stage of the disease may be at the basis of these discrepancies.…”

Section: Discussionmentioning

confidence: 99%

Osteoprotegerin Gene Polymorphisms Are Associated with Subclinical Atherosclerosis in the Mexican Mestizo Population

et al. 2022

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Subclinical atherosclerosis (SA) is the presence of coronary calcification in the absence of cardiovascular symptoms, and it usually progresses to atherosclerotic disease. Studies have shown an association of osteoprotegerin gene (OPG) variants with calcification process in cardiovascular diseases; however, to this day there are no studies that evaluate individuals in the asymptomatic stage of atherosclerotic disease. Therefore, the purpose of this study was to analyze the association of four genetic variants and haplotypes of the OPG gene with the development of SA, through TaqMan genotyping assays. We also aimed to identify potential response elements for transcription factors in these genetic variants. The study included 1413 asymptomatic participants (1041 were controls and 372 were individuals with SA). The rs3102735 polymorphism appeared as a protective marker (OR = 0.693; 95% CI = 0.493–0.974; pheterozygote = 0.035; OR = 0.699; 95% CI = 0.496–0.985; pcodominant 1 = 0.040) and two haplotypes were associated with SA, one as a decreased risk: GACC (OR = 0.641, 95% CI = 0.414–0.990, p = 0.045) and another as an increased risk: GACT (OR = 1.208, 95% CI = 1.020–1.431, p = 0.029). Our data suggest a lower risk of SA in rs3102735 C carriers in a representative sample of Mexican mestizo population.

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Section: Discussionmentioning

confidence: 99%

Osteoprotegerin Gene Polymorphisms Are Associated with Subclinical Atherosclerosis in the Mexican Mestizo Population

et al. 2022

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“…Moreover, increased OPG levels cause artery calci cation and atherosclerosis and thus associate with CVD in the general population and in RA patients [10,12,33,34]. However, only speci c variants of the OPG gene have been associated with atherosclerosis and CVD in non-rheumatic patients in few studies [35][36][37].In RA, only two studies have examined the association of different variants of the OPG gene and atherosclerosis and results are somewhat inconsistent. In accordance with our results, Chung et al found that the CC genotype of the rs2073618 was associated with coronary artery calcium, whereas another study failed to associate any of the examined variants with the risk of CV events and designated a possible protective effect of the OPG CGA haplotype on CV risk in the anti-CCP negative RA subset [17,18].…”

Section: Discussionmentioning

confidence: 99%

“…The rs2073618 polymorphism of the OPG gene and the A1298C (rs1801131) and C677T(rs1801133)polymorphisms of the MTHFR gene were analyzed by polymerase chain reaction (PCR) of genomic DNA, as previously described [37,98].…”

Section: Osteoprotegerin and Mthfr Genotypingmentioning

confidence: 99%

Osteoprotegerin And MTHFR Gene Variations In Rheumatoid Arthritis: Association With Disease Susceptibility And Markers of Subclinical Atherosclerosis

Arida

Nezos

Papadaki

et al. 2021

Preprint

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Objective: To explore whether the osteoprotegerin (OPG) rs2073618 gene variant and the methylenetetrahydrofolate reductase (MTHFR) rs1801131 and rs1801133 polymorphisms contribute to rheumatoid arthritis (RA) susceptibility and RA related subclinical atherosclerosis.Methods: 283 RA patients and 595 healthy controls (HC) were genotyped for OPG and MTHFR gene variants using PCR based assays. Clinical, laboratory parameters and markers of subclinical atherosclerosis (Carotid/Femoral intima media thickness/plaque formation) along with traditional risk factors for atherosclerosis were assessed in RA patients and 280HC.Results: Increased prevalence of the rs2073618CC genotype was detected in RA patients vs HC (p=0.04), especially in RA patients with high serum titers of rheumatoid factor (RF) or anti-cyclic citrullinated peptide (anti-CCP) antibodies compared to HC (p-values:0.0029 and 0.0077, respectively). This genotype was also associated with higher carotid-IMT scores (p=0.01) and marginally with higher rates of carotid plaque formation (p=0.06). MTHFR 1298CC genotype was more prevalent in the anti-CCP positive group compared to HC, with no associations detected with markers of subclinical atherosclerosis. Reduced rates of carotid/femoral plaque formation were detected among RA patients harboring the MTHFR 677TT genotype (p=0.009).Conclusion: OPG and MTHFR gene variations seem to increase susceptibility for seropositive RA and potentially contribute to subclinical atherosclerosis linked to RA.

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“…Genome-wide studies (GWAS) and candidate genes have established the participation of various SNPs in the development of CAD [ 13 , 14 , 15 ]. Unfortunately, GWAS studies do not include Mexican populations and candidate gene studies in Mexicans are scarce [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

MCP-1 rs1024611 Polymorphism, MCP-1 Concentrations, and Premature Coronary Artery Disease: Results of the Genetics of Atherosclerotic Disease (GEA) Mexican Study

Posadas-Sánchez,

Velázquez-Sánchez,

Reyes-Barrera

et al. 2024

Biomedicines

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Monocyte chemoattractant protein-1 (MCP-1) participates in the initiation and progression of atherosclerosis. In vitro studies have reported that the MCP-1 rs1024611 polymorphism is associated with increased MCP-1 concentrations. The study aimed to define whether MCP-1 concentrations are associated with premature coronary artery disease (pCAD) and to establish whether variations in the rs1024611 polymorphism increase MCP-1 concentrations. MCP-1 rs1024611 polymorphism was determined in 972 pCAD patients and 1070 control individuals by real-time PCR. MCP-1 concentrations were determined by the Bio-Plex system. In the total population, men had higher MCP-1 concentrations when compared to women (p < 0.001). When stratified by rs1024611 genotypes, higher MCP-1 concentrations were observed in AA individuals compared to GG subjects (p = 0.023). When performing the analysis considering sex, the differences remained significant in women (AA vs. GG, p = 0.028 and GA vs. GG, p = 0.008). MCP-1 concentrations were similar in pCAD patients and controls (p = 0.782). However, the independent analysis of the studied groups showed that in patients with the AA genotype, MCP-1 concentrations were significantly higher when compared to patients with the GG genotype (p = 0.009). Considering that the AA genotype increases MCP-1 concentration, we evaluated whether, in AA genotype carriers, MCP-1 concentrations were associated with pCAD. The results showed that for every ten pg/mL increase in MCP-1 concentration, the risk of presenting pCAD increases by 2.7% in AA genotype individuals. Individuals with the MCP-1 rs1024611 AA genotype present an increase in MCP-1 concentration. In those individuals, increased MCP-1 concentrations increase the risk of presented pCAD.

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Genetic Variants and Haplotypes in OPG Gene Are Associated with Premature Coronary Artery Disease and Traditional Cardiovascular Risk Factors in Mexican Population: The GEA Study

Cited by 5 publications

References 62 publications

Osteoprotegerin Gene Polymorphisms Are Associated with Subclinical Atherosclerosis in the Mexican Mestizo Population

Osteoprotegerin Gene Polymorphisms Are Associated with Subclinical Atherosclerosis in the Mexican Mestizo Population

Osteoprotegerin And MTHFR Gene Variations In Rheumatoid Arthritis: Association With Disease Susceptibility And Markers of Subclinical Atherosclerosis

MCP-1 rs1024611 Polymorphism, MCP-1 Concentrations, and Premature Coronary Artery Disease: Results of the Genetics of Atherosclerotic Disease (GEA) Mexican Study

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