Genetic variants in acute, acute recurrent and chronic pancreatitis affect the progression of disease in children

Abu‐El‐Haija, Maisam; Valencia, C. Alexander; Hornung, Lindsey; Youssef, Nour; Thompson, Tyler; Barasa, Nathaniel; Wang, Xinjian; Denson, Lee A.

doi:10.1016/j.pan.2019.05.001

Cited by 31 publications

(41 citation statements)

References 34 publications

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“…During the rst attack of AP in children, age, male sex, pancreatic necrosis, and higher Body Mass Index (BMI) have been associated with the progression of ARP. Anatomic abnormalities of the biliary tract, hyperlipidemia, and genetic factors should be evaluated in cases of recurrence [11,16,26]. In our study, among the 19 children (14.6%) with ARP, includes a 2-year-old toddler with congenital bile duct dilatation.…”

Section: Discussionmentioning

confidence: 91%

Clinical characteristics of acute pancreatitis in children: a single-center experience in Western China

Zhong

Tan

Yan

et al. 2020

Preprint

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Background: The diagnosis of pediatric pancreatitis has been increasing over the last 20 years. We aimed to compare the clinical characteristics for pediatric acute pancreatitis (AP) with adult AP, and investigate the risk factor for acute recurrent pancreatitis (ARP) in children. Method: From June 2013 to June 2019, a total of 130 pediatric patients with AP at the inpatient database were enrolled. Univariate analysis and multivariate Cox regression analysis were performed to identify the risk factors for ARP in children. Result: Major etiologic factors in 130 patients were biliary (31.5%), idiopathic (28.5%), trauma (16.2%). There was a significant difference in the constituent ratio of etiology between pediatric patients and adult patients (p<0.001). Compared with the adult patients, the pediatric patients had significantly lower severity (p=0.012) and occurrence rate of pancreatic necrosis (p=0.02). During the follow-up time (34.2±20.8 months), 19 children (14.6%) developed into ARP. Multivariate Cox regression analysis showed that female (p=0.025; OR=3.632; 95%confidence interval(CI) 1.179-11.188), hyperlipidemia (p=0.022; OR=3.480; 95%CI 1.201-10.085), pancreatic necrosis (p=0.001; OR=8.815; 95%CI 2.446-31.774) were the independent risk factors of ARP. The risk of recurrence was significantly different in each etiology group. Hyperlipidemic AP had the highest risk of recurrence over time, while viral and drug-induced AP had the lowest risk of recurrence (p=0.035).Conclusion: Biliary and idiopathic disease were the major etiologies of AP in children. Compared to adults, children tend to have milder disease conditions and a better prognosis. Female, hyperlipidemia, and first AP attack with pancreatic necrosis were associated with the increased risk of ARP.

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Section: Discussionmentioning

confidence: 91%

Clinical characteristics of acute pancreatitis in children: a single-center experience in Western China

Zhong

Tan

Yan

et al. 2020

Preprint

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“…This can be attributed to the recent surge in health education, and improvements in guidelines that resulted in a decline in hospitalization rates. [ 13 15 ]…”

Section: Discussionmentioning

confidence: 99%

“… Incidence of acute pancreatitis among children and adults between the years 2009 and 2016[ 13 15 18 19 ] …”

Section: Discussionmentioning

confidence: 99%

“…A genetic risk of AP is not to be confused with hereditary pancreatitis, which is a rare autosomal dominant genetic disorder of the pancreas with incomplete penetrance. In a study conducted by Abu-El-Haija et al .,[ 15 ] eight genes were detected by TruSeq enrichment and Illumina sequencing to be involved in pancreatitis: CASR, CFTR, CLDN2, CPA1, CTRC, PRSS1, SBDS , and SPINK1 . The most common gene implicated was found to be CFTR , at 11%.…”

Section: Discussionmentioning

confidence: 99%

“…The study findings were similar to others previously published, with similar patient populations. [ 15 ]…”

Section: Discussionmentioning

confidence: 99%

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Clinical review of acute, recurrent, and chronic pancreatitis: Recent updates of 2013–2019 literature

et al. 2020

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A BSTRACT The increasing prevalence of pancreatic disorders worldwide has provided challenges in its clinical care and management. This review was aimed to evaluate recent literature on diagnosis, treatment, and management of acute pancreatitis (AP), recurrent acute pancreatitis (RAP), as well as chronic pancreatitis (CP) documented during the past 5–6 years. An extensive literature review was carried out based on studies within the last 6 years (2013–2019). Articles were selected based on updates and therapeutic management. Critical appraisal of literature was performed using the Mixed Methods Appraisal Tool (MMAT), and a PRISMA flowchart was used to avoid bias. The study identified recent updates on the prophylactic treatment in preventing RAP. The risk factors and the therapeutic management options were evaluated and discussed. The findings show that although many lifesaving new protocols are available for implementation in clinical practice, current literature lacks detailed and comprehensive guidelines that cover special populations and comorbidities. The literature evaluated showed that eight genes were involved in pancreatitis, CASR, CFTR, CLDN2, CPA1, CTRC, PRSS1, SBDS, and SPINK1 , but the most common gene implicated was found to be CFTR , at 11%. Therefore, it is recommended that a comprehensive guideline should be formulated to facilitate the diagnosis, management, treatment, and prophylactic measures of pancreatic disease. This could in turn reduce disease complications and hospitalization time, and improve clinical practice for management of pancreatitis.

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Genetic Factors in Acute Pancreatitis

Ramsey

Papachristou

2023

The Pancreas

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Genetic variants in acute, acute recurrent and chronic pancreatitis affect the progression of disease in children

Cited by 31 publications

References 34 publications

Clinical characteristics of acute pancreatitis in children: a single-center experience in Western China

Clinical characteristics of acute pancreatitis in children: a single-center experience in Western China

Clinical review of acute, recurrent, and chronic pancreatitis: Recent updates of 2013–2019 literature

Genetic Factors in Acute Pancreatitis

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