Genetic variants in dopamine pathways affect personality dimensions displayed by patients with eating disorders

Early Life Stress and the Onset of Obesity: Proof of MicroRNAs’ Involvement Through Modulation of Serotonin and Dopamine Systems’ Homeostasis

“…In addition, overexpression of let-7d is negatively correlated with the expression of DRD3 in the hippocampus of mice (Bahi and Dreyer, 2018). The activity of the DRD3 is controversy in the context of food intake, but some evidences associate it with eating disorders and decreased food intake (Thomsen et al, 2017;González et al, 2019). The expression of DAT, the major controller of dopamine levels in the synaptic clefts, is post-transcriptionally regulated on cell culture of dopaminergic neurons by miR-137 and miR-491 (Jia et al, 2016).…”

A Systematic Review of Genetic Polymorphisms Associated with Binge Eating Disorder

“…Davis et al focused on Taq1A as a polymorphism of the DRD2 gene and found that BED subjects carrying the A1 allele of Taq1A showed higher reward sensitivity [ 25 ]. In contrast, Gonzalez et al and Palmeira et al, who also analyzed Taq1A as a polymorphism of the DRD2 gene, did not find a significant result [ 15 , 24 ]. Davis et al focused their analysis on DRD2 and OPRM1 because they are jointly associated with the function of reward mechanisms in the brain.…”

“…Nine studies examined the role of 19 polymorphisms of 6 dopaminergic genes in BED: DRD2 [ 15 , 24 , 25 , 26 , 27 ], ANKK1 27,28, OPRM1 [ 26 ], COMT [ 17 , 29 ], DAT1 [ 15 , 16 ], and DRD3 [ 15 ].…”

“…The Taq1A polymorphism of DRD2/ANKK1 genes was extensively analyzed in the selected articles, and these studies showed all the significant results mentioned above [ 15 , 24 , 25 , 26 , 27 , 28 ]. Davis et al focused on Taq1A as a polymorphism of the DRD2 gene and found that BED subjects carrying the A1 allele of Taq1A showed higher reward sensitivity [ 25 ].…”

“…Other studies have investigated the possible role of the dopamine active transporter (DAT) SLC6A3 and D3 receptors, which are localized in the limbic areas of the brain and are associated with cognitive, emotional, and endocrine functions. Unfortunately, there is not enough available information linking these genes to eating disorders [ 15 ].…”