Genetic variants in noncoding PIWI‐interacting RNA and colorectal cancer risk

Chu, Haiyan; Xia, Liping; Qiu, Xiaonan; Gu, Dongying; Zhu, Linjun; Jin, Jing; Hui, Gaoyun; Hua, Qiuhan; Du, Mulong; Tong, Na; Chen, Jinfei; Zhang, Zhengdong; Wang, Meilin

doi:10.1002/cncr.29314

Cited by 59 publications

(31 citation statements)

References 54 publications

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“…One study showed that piRNAs are important determinants of CRC risk by binding to Piwi, and that genetic variants in piRNAs modulate CRC susceptibility. They identified seven piRNA SNPs in a search of all known human piRNAs available, and investigated the association between these seven SNPs and the risk of CRC [ 112 ]. The SNP rs11776042 in piR-015551, which may be generated from a type of lncRNA called LNC00964-3, was significantly associated with a decreased risk of CRC in an additive model; however, the protective effect was not significant after multiple comparison correction.…”

Section: Piwi-interacting Rnas In Crcmentioning

confidence: 99%

Regulatory Roles of Non-Coding RNAs in Colorectal Cancer

Wang

Song

et al. 2015

IJMS

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Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs. These ncRNAs might become novel biomarkers and targets as well as potential therapeutic tools for the treatment of CRC in the near future and this review may provide important clues for further research on CRC and for the selection of effective therapeutic targets.

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Section: Piwi-interacting Rnas In Crcmentioning

confidence: 99%

Regulatory Roles of Non-Coding RNAs in Colorectal Cancer

Wang

Song

et al. 2015

IJMS

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“…Studies on the biological functions and possible clinical relevance of piRNAs in colorectal cancer (CRC) are still in the beginning. In 2015, Chu and colleagues (17) identified 7 common single-nucleotide polymorphisms in 9 known piRNAs. Further, they revealed that piR-015551 (DQ591252) may be generated from long noncoding RNA LNC00964-3, which is significantly downregulated in CRC tissues and may be involved in disease development.…”

Section: Introductionmentioning

confidence: 99%

Circulating PIWI-Interacting RNAs piR-5937 and piR-28876 Are Promising Diagnostic Biomarkers of Colon Cancer

Vychytilova-Faltejskova

Štítkovcová

Radová

et al. 2018

Cancer Epidemiology, Biomarkers &Amp; Prevention

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The early detection of colon cancer is one of the main prerequisites for successful treatment and mortality reduction. Circulating PIWI-interacting RNAs (piRNA) were recently identified as novel promising biomarkers. The purpose of the study was to assess the profiles of piRNAs in blood serum of colon cancer patients with the aim to identify those with high diagnostic potential. Blood serum samples from 403 colon cancer patients and 276 healthy donors were included in this 3-phase biomarker study. Large-scale piRNA expression profiling was performed using Illumina small RNA sequencing. The diagnostic potential of selected piRNAs was further validated on independent training and validation sets of samples using RT-qPCR. In total, 31 piRNAs were found to be significantly deregulated in serum of cancer patients compared with healthy donors. Based on the levels of piR-5937 and piR-28876, it was possible to differentiate between cancer patients and healthy donors with high sensitivity and specificity. Moreover, both piRNAs exhibited satisfactory diagnostic performance also in patients with stage I disease and enabled detection of colon cancer with higher sensitivity than currently used biomarkers CEA and CA19-9. Finally, the expression of analyzed piRNAs in blood restored significantly 1 month after the surgical resection. Based on our findings, piRNAs are abundant in human blood serum. Furthermore, their levels in colon cancer have been observed to be significantly deregulated. However, their involvement in carcinogenesis must be further established. piRNAs could serve as promising noninvasive biomarkers for early detection of colon cancer. .

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“…Similarly, the association between piR59056, piR-54878, and piR-62701 and recurrence-free survival was also observed in colon cancer. Chu et al [91] observed that mRNA expression levels of LNC00964-3 which is an lncRNA that included the piR-015551 sequence were significantly lower in colorectal cancer (CRC) tissues than in corresponding normal tissues. The expression of piR-015551 was positively correlated with the LNC00964-3 expression levels, indicating that piR-015551 may be possibly generated from LNC00964-3, which may be involved in the development of CRC.…”

Section: Introductionmentioning

confidence: 99%

PIWI Proteins and PIWI-Interacting RNA: Emerging Roles in Cancer

Han

Xia

et al. 2017

Cell Physiol Biochem

127

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P-Element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a type of noncoding RNAs (ncRNAs) and interact with PIWI proteins. piRNAs were primarily described in the germline, but emerging evidence revealed that piRNAs are expressed in a tissue-specific manner among multiple human somatic tissue types as well and play important roles in transposon silencing, epigenetic regulation, gene and protein regulation, genome rearrangement, spermatogenesis and germ stem-cell maintenance. PIWI proteins were first discovered in Drosophila and they play roles in spermatogenesis, germline stem-cell maintenance, self-renewal, retrotransposons silencing and the male germline mobility control. A growing number of studies have demonstrated that several piRNA and PIWI proteins are aberrantly expressed in various kinds of cancers and may probably serve as a novel biomarker and therapeutic target for cancer treatment. Nevertheless, their specific mechanisms and functions need further investigation. In this review, we discuss about the biogenesis, functions and the emerging role of piRNAs and PIWI proteins in cancer, providing novel insights into the possible applications of piRNAs and PIWI proteins in cancer diagnosis and clinical treatment.

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Genetic variants in noncoding PIWI‐interacting RNA and colorectal cancer risk

Abstract: The current findings reveal the possibility that piR-015551 may be generated from LNC00964-3, which may be involved in the development of CRC.

Cited by 59 publications

References 54 publications

Regulatory Roles of Non-Coding RNAs in Colorectal Cancer

Regulatory Roles of Non-Coding RNAs in Colorectal Cancer

Circulating PIWI-Interacting RNAs piR-5937 and piR-28876 Are Promising Diagnostic Biomarkers of Colon Cancer

PIWI Proteins and PIWI-Interacting RNA: Emerging Roles in Cancer

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