Genetic variants underlying vitamin D metabolism and VDR–TGFβ-1–SMAD3 interaction may impact on HCV progression: a study based on dbGaP data from the HALT-C study

Azevedo, Laura Alencastro de; Matte, Úrsula; Silveira, Themis Reverbel da; Álvares‐da‐Silva, Mário Reis

doi:10.1038/jhg.2017.75

Cited by 12 publications

(8 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The relationship between liver fibrosis progression and the presence of VDR polymorphisms (ApaI, TaqI and BsmI) has been investigated, indicating that in PBC patients, BsmI and TaqI were associated with progressive cirrhosis 10 and in NAFLD patients, VDR mRNA expression and profibrogenic genes were significantly affected by BsmI polymorphism 18 . The effect of bAt haplotype in fibrosis progression has been investigated in HCV patients as well, giving conflicting results 18 , 19 , 32 . Our results indicate that the presence of ApaI polymorphism (AA genotype) is related to significant higher levels of IL-1β and IL-8.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of vitamin D receptor (VDR) gene polymorphisms in liver cirrhosis

Triantos

Αγγελετοπούλου

Kalafateli

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Several polymorphisms in the vitamin D receptor (VDR) are associated with the occurrence of chronic liver disease. Here, we investigated the association between BsmI, ApaI, TaqI and FokI VDR polymorphisms and the severity of liver cirrhosis in relation to serum cytokine and lipopolysaccharide binding protein (LBP) levels and their role on survival in cirrhotic patients. We found that patients harboring the BB genotype had higher MELD score, and they were mainly at CP stage C; patients harboring the AA genotype had increased LBP, IL-1β and IL-8 levels, and they were mostly at CP stage C; TT genotype carriers had higher MELD score and they were mainly at CP stage C and FF genotype carriers had lower IL-1β levels when compared to Bb/bb, Aa/aa, Tt/tt and Ff/ff genotypes respectively. In the multivariate analysis ApaI, BsmI and TaqI polymorphisms were independently associated with liver cirrhosis severity. In the survival analysis, the independent prognostic factors were CP score, MELD and the FF genotype. Our results indicate that the ApaI, TaqI and BsmI polymorphisms are associated with the severity of liver cirrhosis, through the immunoregulatory process. Survival is related to the FF genotype of FokI polymorphism, imparting a possible protective role in liver cirrhosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic significance of vitamin D receptor (VDR) gene polymorphisms in liver cirrhosis

Triantos

Αγγελετοπούλου

Kalafateli

et al. 2018

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The GC rs222020 variant is related to the risk of rickets (Zhang et al, 2013a). Additionally, the HALT-C study followed 692 chronic HCV patients after Peg-IFN therapy over 4 years, and the GC rs222020 variant was associated with worsening liver fibrosis (de Azevedo et al, 2017). However, this study did not investigate the effect of the GC variants on the virological response after treatment.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D-Binding protein Gene Polymorphism Predicts Pegylated Interferon-Related HBsAg Seroclearance in HBeAg-Negative Thai Chronic Hepatitis B Patients: A Multicentre Study

Thanapirom

Suksawatamnuay

Sukeepaisarnjaroen

et al. 2019

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Background: Vitamin D deficiency is related to poor clinical outcomes in patients with chronic hepatitis B virus (HBV) infection. Methods: We aimed to investigate the association between the genetic variants in the vitamin D metabolic pathway and the response to pegylated interferon (Peg-IFN) therapy in patients with HBeAg-negative chronic HBV infection. One hundred seven patients treated with Peg-IFN for 48 weeks were selected from 13 specialty hospitals. Eight genotypes of vitamin D cascade genes, including CYP27B1 (rs10877012), DHCR7 (rs12785878), CYP2R1 (rs2060793, rs12794714) and GC (rs4588, rs7041, rs222020, rs2282679), were found. Results: Eighty-two patients (83.7%) were infected with HBV genotype C. Eight patients had compensated liver cirrhosis (8.7%). At 24 weeks after treatment discontinuation, 41 patients (42.3%) achieved sustained treatment response, 53 (55.2%) obtained HBV DNA<2,000 IU/ml, 6 (5.6%) gained HBsAg seroclearance, 2 (1.9%) had HBsAg seroconversion and 69 (64.5%) exhibited alanine aminotransferase (ALT) normalization. Multivariate analysis revealed that baseline HBsAg level (OR =0.06, 95% CI: 0.08-0.49, p=0.008) and the GC rs222020 TT genotype (OR=17.72, 95% CI: 1.07-294.38, p=0.04) independently predicted sustained HBsAg seroclearance. In addition, this genotype was a predictor for normalization of ALT (OR=4.61, 95%CI: 1.59-13.40, p=0.005) after therapy. The HBsAg levels at baseline and during and post-treatment tended to be reduced with the GC rs222020 TT compared with the non-TT genotypes. The other studied polymorphisms were not associated with treatment response. Conclusions: The GC rs222020 TT genotype, which is a variant in the vitamin D-binding protein gene, could identify HBeAg-negative patients who have a high probability to achieve HBsAg clearance and ALT normalization after treatment with Peg-IFN. global health problem with approximately 250 million people were chronically infected (Schweitzer et al., 2015).

show abstract

“…Було У літературі є відомості про участь ВD у регуляції функцій жіночої репродуктивної системи. Найчастіше описується статус ВD у пацієнток із синдромом полікістозних яєчників, ендометріозом, лейоміомою матки, а також його рівень пов'язують із результатом екстракорпорального запліднення [14][15][16][17]. Незважаючи на те що статус ВD у дітей і підлітків вивчається багатьма дослідниками, його вплив на формування менструальної функції та її порушення в періоді пубертату вивчений недостатньо, про що свідчать поодинокі роботи [18,19].…”

Section: вступunclassified

Vitamin D level and hormonal status association in adolescent girls with oligomenorrhea

Dynnik

Druzhynina

2021

View full text Add to dashboard Cite

Research objective: to determine the frequency of vitamin D deficiency and insufficiency to identify its association with reproductive hormones in adolescent girls with oligomenorrhea.Materials and methods. The work was carried out according to the results of clinical and instrumental examination of 68 adolescent girls 12–18 years old with oligomenorrhea, who were treated at the Department of Pediatric Gynecology of the State Institution “Institute for Children and Adolescents Health Care of the NAMS of Ukraine”. Patients were divided into two groups depending on the body mass index (BMI): group I – with a body weight deficit (BMI 16.31 ± 0.18 kg/m2), group II – with a BMI within physiological norm (20.0 ± 0.25 kg/m2). All patients underwent a comprehensive clinical and laboratory examination: luteinizing, follicle-stimulating hormones, prolactin, estradiol, testosterone, cortisol, 25(OH)D were determined in blood serum. Multivariate regression analysis was using for analyze the association of gonаdotropic, steroid hormones with vitamin D. The main characteristics of the object discrimination model are presented in the form of tables.Results. The article provides a comparative analysis of the hormonal profile and vitamin D level depending on BMI. It was revealed that a reduced 25(OH)D value was characteristic not only in patients with menstrual dysfunction, but also in peers with normal menstrual function. Schemes that characterize the pituitary-gonadal association with vitamin D were constructed based on the results of multiple regression analysis. Their features were determined in girls with different body weights. In patients with low energy resources there were direct associations between individual indicators of gonadotropins (follicle-stimulating hormone), steroid hormones (estradiol, cortisol) and vitamin D. An inverse association was observed between vitamin D and cortisol and prolactin in girls with balanced energy status.Conclusions. The reduced content of vitamin D is characteristically for patients with menstrual dysfunctions by the type of oligomenorrhea. Associations of gonadotropic, steroid hormones and vitamin D, depending on the energy status (nutrition) of patients with oligomenorrhea were revealed.

show abstract

Genetic variants underlying vitamin D metabolism and VDR–TGFβ-1–SMAD3 interaction may impact on HCV progression: a study based on dbGaP data from the HALT-C study

Cited by 12 publications

References 53 publications

Prognostic significance of vitamin D receptor (VDR) gene polymorphisms in liver cirrhosis

Prognostic significance of vitamin D receptor (VDR) gene polymorphisms in liver cirrhosis

Vitamin D-Binding protein Gene Polymorphism Predicts Pegylated Interferon-Related HBsAg Seroclearance in HBeAg-Negative Thai Chronic Hepatitis B Patients: A Multicentre Study

Vitamin D level and hormonal status association in adolescent girls with oligomenorrhea

Contact Info

Product

Resources

About