Genetic Variation and Improvement in Reproduction

Bradford, G. E.; Spearow, Jimmy L.; Hanrahan, J. P.

doi:10.1016/b978-0-08-057109-6.50024-0

Reproduction in Domestic Animals 1991

DOI: 10.1016/b978-0-08-057109-6.50024-0

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Genetic Variation and Improvement in Reproduction

G. E. Bradford¹,

Jimmy L. Spearow²,

J. P. Hanrahan³

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Cited by 5 publications

(1 citation statement)

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“…Reproductive traits, including natural and hormone-induced ovulation rate, litter size, testis weight and sperm production, show a high degree of genetic variation in many different species and can be altered by selective breeding (10)(11)(12)(13)(14). Selection for large litter size results in changes in components of the hypothalamicpituitary-gonadal axis in females, including changes in ovarian sensitivity to gonadotropins, follicular steroidogenesis, and sensitivity to estrogen-negative feedback (15)(16)(17)(18)(19)(20).…”

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confidence: 99%

Genetic variation in physiological sensitivity to estrogen in mice

Spearow

O'Henley

Doemeny

et al. 2001

APMIS

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Spearow JL, O'Henley P, Doemeny P, Sera R, Leffler R, Sofos T, Barkley M. Genetic variation in physiological sensitivity to estrogen in mice. APMIS 2001;109:356-64.Genetic variation in susceptibility to endocrine disruption by estrogenic agents was examined in juvenile male mice. Mice were implanted with increasing doses of estradiol (E2) at 3 weeks of age and reproductive responses were determined 3 weeks later. Greater than 16-fold differences in susceptibility to the disruption of reproductive development by E2 were detected between strains of mice. CD-1 was much more resistant to the inhibition of testes weight, vesicular gland weight and spermatogenesis by increasing doses of E2. Spermatid maturation was eliminated by low doses of E2 in unselected strains such as C17/Jls and C57BL/6J. In contrast, widely used, large litter size selected CD-1 mice showed little or no inhibition in spermatogenesis even in response to 16-fold higher doses of E2. Testicular sulfotransferase activity (EST) per gram body weight was 3.5-fold higher in untreated CD-1 than in B6 strain males. This suggests that genetic differences in testicular EST activity may play a critical role in the detoxification of estrogens. These and other findings emphasize the need to identify and study genetic variation in sensitivity to estrogen in laboratory animal models used to assess the risk of xenobiotic estrogen exposure.

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mentioning

confidence: 99%

Genetic variation in physiological sensitivity to estrogen in mice

Spearow

O'Henley

Doemeny

et al. 2001

APMIS

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Seasonal effects on puberty and reproductive characteristics of female Chios sheep and Damascus goats born in autumn or in February

Papachristoforou

Koumas

Photiou

2000

Small Ruminant Research

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Genetic variation in physiological sensitivity to estrogen in mice^Note

Spearow

O'Henley

Doemeny

et al. 2001

APMIS

View full text Add to dashboard Cite

Genetic variation in susceptibility to endocrine disruption by estrogenic agents was examined in juvenile male mice. Mice were implanted with increasing doses of estradiol (E2) at 3 weeks of age and reproductive responses were determined 3 weeks later. Greater than 16-fold differences in susceptibility to the disruption of reproductive development by E2 were detected between strains of mice. CD-1 was much more resistant to the inhibition of testes weight, vesicular gland weight and spermatogenesis by increasing doses of E2. Spermatid maturation was eliminated by low doses of E2 in unselected strains such as C17/Jls and C57BL/6J. In contrast, widely used, large litter size selected CD-1 mice showed little or no inhibition in spermatogenesis even in response to 16-fold higher doses of E2. Testicular sulfotransferase activity (EST) per gram body weight was 3.5-fold higher in untreated CD-1 than in B6 strain males. This suggests that genetic differences in testicular EST activity may play a critical role in the detoxification of estrogens. These and other findings emphasize the need to identify and study genetic variation in sensitivity to estrogen in laboratory animal models used to assess the risk of xenobiotic estrogen exposure.

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Genetic Variation and Improvement in Reproduction

Cited by 5 publications

References 61 publications

Genetic variation in physiological sensitivity to estrogen in mice

Genetic variation in physiological sensitivity to estrogen in mice

Seasonal effects on puberty and reproductive characteristics of female Chios sheep and Damascus goats born in autumn or in February

Genetic variation in physiological sensitivity to estrogen in mice^Note

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Genetic Variation and Improvement in Reproduction

Cited by 5 publications

References 61 publications

Genetic variation in physiological sensitivity to estrogen in mice

Genetic variation in physiological sensitivity to estrogen in mice

Seasonal effects on puberty and reproductive characteristics of female Chios sheep and Damascus goats born in autumn or in February

Genetic variation in physiological sensitivity to estrogen in miceNote

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About

Genetic variation in physiological sensitivity to estrogen in mice^Note