Genetic variation in a miR-335 binding site in BIRC5 alters susceptibility to lung cancer in Chinese Han populations

Zu, Yukun; Ban, Jin-Bao; Xia, Zhenxiong; Wang, Jianbo; Cai, Yong; Wei, Ping; Sun, Wei

doi:10.1016/j.bbrc.2012.12.001

Cited by 33 publications

(18 citation statements)

References 21 publications

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“…miR-335 serves as a tumor suppressor miRNA, is transcribed from the genomic region on chromosome 7q32.2 (76) and is downregulated in various human digestive malignancies, such as pancreatic carcinoma, hepatocellular carcinoma, colorectal cancer and gastric cancer (77)(78)(79)(80). A similar result was also observed in GBC patients.…”

Section: Tumor Suppressor Micrornassupporting

confidence: 56%

The role of microRNAs in gallbladder cancer

Yang

Zhang

et al. 2016

Molecular and Clinical Oncology

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Abstract. MicroRNAs (also referred to as miRNAs or miRs) play a crucial role in post-transcriptional gene regulation and serve as negative gene regulators by controlling a variety of target genes and regulating diverse biological processes, such as cell proliferation, invasion, migration and apoptosis. Aberrant expression of miRNAs is associated with the development and progression of cancer. Recent studies have reported that miRNAs may repress or promote the expression of cancer-related genes via several different signaling pathways in gallbladder cancer (GBC) patients and may function as tumor suppressors or oncogenes, thus providing a promising tool for the diagnosis and therapeutics of GBCs. In this review, we summarize the role of dysregulawted miRNA expression in the signaling pathways implicated in GBC and discuss the significant role of circulating miRNAs in GBC. Therefore, miRNAs may serve as novel therapeutic targets as well as diagnostic or prognostic markers in GBC.

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Section: Tumor Suppressor Micrornassupporting

confidence: 56%

The role of microRNAs in gallbladder cancer

Yang

Zhang

et al. 2016

Molecular and Clinical Oncology

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“…SNP rs2239680 in the miR-335 binding site of the oncogene BIRC5 may alter the susceptibility to lung cancer. C allele carriers were found to be predisposed to lung cancer and advanced pathologic stage (Zu et al, 2013). let-7 is one of the most widely studied miRNAs and functions in many biological processes.…”

Section: Discussionmentioning

confidence: 99%

A single nucleotide polymorphism in the promoter region of let-7 family is associated with lung cancer risk in Chinese

et al. 2015

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ABSTRACT. Lung cancer is a complex polygenic disease and many genetic factors are involved in the development of the disease. As one of the most important and widely studied families of microRNA, let-7 appears to play an important role in initiation and progression of lung cancer. Any small changes in miRNA level or its target point can cause significant changes in gene function. In this study, we examined whether a single-nucleotide polymorphism in the promoter region of the let-7 family (rs10877887) is associated with the susceptibility to L.Q. Shen et al. 4506©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 4505-4512 (2015) and prognosis of lung adenocarcinoma cancer. A hospital-based casecontrol research model was used in our study. The single-nucleotide polymorphism was genotyped in 69 lung cancer patients and 75 healthy controls by direct sequencing. The correlation between rs10877887 genotypes and the susceptibility to lung cancer was evaluated using an unconditional logistic regression model. Populations with the CT+CC genotype had a significantly increased AC risk compared to those with the TT genotype (CT+CC vs TT: P = 0.043, OR = 2.032, 95%CI = 1.018-4.054). Furthermore, the risk effect was greater in subgroups of females over 60 years old (CT+CC vs TT: OR = 6.857, 95%CI = 1.425-33.008, P = 0.012), and the C allele were confirmed to be a risk factor related to lung cancer in these females (P = 0.012). The singlenucleotide polymorphism rs10877887 in the promoter region of the let-7 family was found to be responsible for the susceptibility to lung adenocarcinoma cancer in Chinese individuals. This association was significantly stronger in females who were more than 60 years old.

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“…gov/cgi-bin/snpinfo/snpfunc.cgi). Combined with other SNPs in the 3'UTR or promoter region, the variant rs2239680 is jointly involved in cancer susceptibility (8,12).…”

Section: Birc5/survivin 3'utr Selected Variants and Putative Mirna Bimentioning

confidence: 99%

“…Zu et al evaluated the association between genetic variants in the 3' untranslated region (3'UTR) of cancer-related genes and risk of lung cancer in Chinese populations, and defined a 3'UTR single nucleotide polymorphism (SNP) in the human BIRC5 oncogene that may increase individual susceptibility to lung cancer, possibly by attenuating the interaction between BIRC5 and miRNA-335 (8). BIRC5/survivin directly binds to the promoter of the miRNA-335 cluster, activating its transcription, and negatively modulating the translation of BIRC5/survivin miRNAs by binding sites in their 3'UTRs (8). In addition, a number of studies have revealed that BIRC5/survivin variants may play crucial roles in carcinogenesis (2).…”

Section: Introductionmentioning

confidence: 99%