Genetic variation in BDNF is associated with allergic asthma and allergic rhinitis in an ethnic Chinese population in Singapore

Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma

“…46,47 The majority of the miRNA groups also target the phosphoinositide 3-kinase-Akt pathway, which is another particularly well-studied signaling cascade in T H 2 inflammation. 48,49 Furthermore, there is emerging evidence in the literature that implicates neurotrophin 50,51 and insulin signaling in patients with allergic lung diseases. 52 Focal adhesion pathways targeted by group 2 and 3 miRNAs in our study are likely involved in changes in airway basement membrane and airway smooth muscle in asthmatic patients.…”

Val66Met polymorphism in the BDNF gene in children with bronchial asthma

“…There are only a few reports on the possible interaction between genetic variation in the BDNF gene and bronchial asthma. Andiappan et al studied the relationship between SNPs in the BDNF gene and genetic predisposition to allergic rhinitis and bronchial asthma in an ethnic Chinese population of Singapore. Their results identified a significant association for the tag SNP rs10767664 with allergic rhinitis ( P = 0.0007, OR 1.3) or bronchial asthma ( P = 0.0005, OR 1.3), using a dominant model of association.…”

Poor Reproducibility of Allergic Rhinitis SNP Associations

“…The population used in this study consists of 1024 AR cases (549 females, 475 males, mean age 22 years) with symptomatic dust mite induced AR and 605 controls (449 females, 156 males, mean age 22 years) with no atopy and allergic symptomology. This study population has previously been analyzed in several AR studies [4], [35], [36], [37], [38].…”