Genetic Variation in IL-8 Associated with Increased Risk and Poor Prognosis of Breast Carcinoma

IL-8-251A>T polymorphism is associated with breast cancer risk: a meta-analysis

“…A common single nucleotide polymorphism at position -251 of the IL-8 promoter region was described in 2000, and consequent evidences demonstrated the IL-8-251A/T polymorphism was associated with IL-8 production or protein expression both in vivo and in vitro (Hull et al 2000;Taguchi et al 2005;Ohyauchi et al 2005). To date, many epidemiological studies have been done to evaluate the association between IL-8-251A[T polymorphism and breast cancer (Liu et al 2007;KamaliSarvestani et al 2007;Smith et al 2004;Snoussi et al 2006Snoussi et al , 2010Vogel et al 2007). However, the results were rather inconsistent, partially due to the relative small sample size of individual studies.…”

Interleukin-8 expression associated with canine mammary tumors

“…Both tumor cells and cells participating in inflammation produce cytokines and chemokines, which mediate many aspects of inflammation and profoundly affect the development of chronic diseases, including cancer (Snoussi et al, 2006). Interleukin-8 (IL-8) is a chemokine (chemotactic cytokine) produced by monocytes, lymphocytes, endothelial cells and epithelial cells, fibroblasts and a range of other cells in response to stimuli such as lipopolysaccharides from Gram-negative bacteria and other cytokines (e.g., TNF-α and IL-1B) (Moulton, 1990).…”

“…Interleukin-8 (IL-8) is a chemokine (chemotactic cytokine) produced by monocytes, lymphocytes, endothelial cells and epithelial cells, fibroblasts and a range of other cells in response to stimuli such as lipopolysaccharides from Gram-negative bacteria and other cytokines (e.g., TNF-α and IL-1B) (Moulton, 1990). Breast cancer tissues have been shown to express high levels of IL-8 (Snoussi et al, 2006).…”

“…IL-8 is a potent chemoattractant and activator of neutrophils and lymphocytes (Monton et al, 1997;Snoussi et al, 2006). It produces proinflammatory effects in response to many human tumor types, such as ovarian, lung, urinary bladder, prostate and pancreas cancers, as well as head and neck squamous carcinoma and melanoma.…”

“…It produces proinflammatory effects in response to many human tumor types, such as ovarian, lung, urinary bladder, prostate and pancreas cancers, as well as head and neck squamous carcinoma and melanoma. IL-8 has been shown to enhance breast cancer progression through mitogenic and angiogenic properties (Snoussi et al, 2006). IL-8 is a key factor in tumor angiogenesis (Li et al, 1998).…”