Genetic Variation in PSCA is Associated with Bladder Cancer Susceptibility in a Korean Population

Lee, Jun-Ho; Song, Ho Jun; Kim, Heung Dong; Kweon, Sun‐Seog; Yun, Yong-Woon; Choi, Jin‐Su; Jung, Sang-Don; Kwon, Dong Deuk; Kim, Soo Hyun; Choi, Yoo‐Duk; Shin, Min‐Ho

doi:10.7314/apjcp.2014.15.20.8901

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…For PSCA meta-analysis, a total of 27 articles ([ 24 , 28 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ] Figure 1 ) were found eligible. Remarkably, the study by Lochhead et al (2011) analyzed the association of rs2294008 polymorphism with GC risk in Poland and USA population, while the EC risk to USA population, and hence these were counted as three different studies [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

Impact of DCC (rs714) and PSCA (rs2294008 and rs2976392) Gene Polymorphism in Modulating Cancer Risk in Asian Population

Chandra

Kim

Gupta

et al. 2016

Genes

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Multiple studies have investigated the association of gene variant of Deleted in colorectal carcinoma (DCC) and Prostate Stem cell antigen (PSCA) with various cancer susceptibility; however, the results are discrepant. Since SNPs are emerging as promising biomarker of cancer susceptibility, here, we aimed to execute a meta-analysis of DCC (rs714 A > G) and PSCA (rs2294008 C > T, rs2976392 G > A) polymorphism to demonstrate the more accurate strength of these associations. We followed a rigorous inclusion/exclusion criteria and calculated the pooled odds ratios (ORs) and 95% confidence intervals (CIs). Overall, the pooled analysis showed that the DCC rs714 conferred increased risk of cancer only in Asians (AA vs. GG: OR = 1.86, p ≤ 0.0001; AG vs. GG: OR = 1.43, p = 0.005; GA + AA vs. GG: OR = 1.66, p ≤ 0.0001; AA vs. GG + GA; OR = 1.52, p ≤ 0.004, A vs. G allele: OR = 1.41, p ≤ 0.0001). PSCA rs2294008 was associated with increased overall cancer risk (TT vs. CC: OR = 1.28, p = 0.002; CT vs. CC: OR = 1.21, p ≤ 0.0001; CT + TT vs. CC: OR = 1.24, p ≤ 0.0001; TT vs. CC + CT; OR = 1.17, p ≤ 0.005, T vs. C allele: OR = 1.16, p ≤ 0.0001); however, in stratified analysis this association was limited only to gastric and bladder cancer and the strength was more prominent in Asians. In contrast, the PSCA rs2976392 SNP did not modulate the cancer risk. Therefore, we concluded that rs714 and rs2294008 polymorphism may represent a potential genetic biomarker for cancer risk in Asians and gastric as well as bladder cancer, respectively. However, since our study is limited to Asians and cancer types, further larger studies involving other cancers and/or population, gene-environment interactions and the mechanism of DCC and PSCA gene deregulation are desired to define the role of genotype with overall cancer risk.

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Section: Resultsmentioning

confidence: 99%

Impact of DCC (rs714) and PSCA (rs2294008 and rs2976392) Gene Polymorphism in Modulating Cancer Risk in Asian Population

Chandra

Kim

Gupta

et al. 2016

Genes

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“…The studied cancer type included gastric cancer [8, 14-17, 20-22, 25, 26, 31, 32, 34, 39, 41-43], bladder cancer [9, 18, 23, 28, 35, 40], prostate cancer [19], esophageal cancer [20, 33], breast cancer [24], colorectal cancer [27], and gallbladder cancer [29, 30]. In term of ethnicity, 21 studies were performed among Asians, 10 studies among Caucasians, and one study among Africans.…”

Section: Resultsmentioning

confidence: 99%

PSCA s2294008 C>T and rs2976392 G>A polymorphisms contribute to cancer susceptibility: evidence from published studies

Dai

Hua

et al. 2015

Genes Cancer

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PSCA gene plays an important role in cell adhesion, proliferation and survival.Increasing studies have focused on the association of PSCA gene rs2294008 C>T and rs2976392 G>A with cancer risk. However, the conclusions were inconsistent. Therefore, we performed a meta-analysis to elucidate whether there is a true association, or artifact. We systematically searched eligible studies from MEDLINE, EMBASE and CBM database. Odds ratios and 95% confidence intervals were used to evaluate the strength of the association. The final analysis included 32 studies consisting of 30028 cases and 38765 controls for the rs2294008 C>T polymorphism, and 14 studies with 8190 cases and 7176 controls for the rs2976392 G>A polymorphism. Consequently, the PSCA rs2294008 C>T polymorphism was significantly associated with increased overall cancer risk. Further stratifications indicated the increased risk was more pronounced for gastric (diffused type and non-gastric cardia adenocarcinoma) and bladder cancer. A similar association was observed for the rs2976392 G>A polymorphism. This meta-analysis demonstrated that both of the PSCA rs2294008 C>T and rs2976392 G>A polymorphisms are associated with increased cancer risk, especially for gastric cancer and bladder cancer. Further large-scale studies with different ethnicities and subtypes of gastric cancer are required to confirm the results from this meta-analysis.

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“…Finally, after our careful selection, ten case-control studies considering 14,021 cases and 26,871 controls were included in this meta-analysis. [5,6,16–22] The publication years of the assessed studies ranged from 2009 to 2017. Of these, there were two studies of Caucasian descendants considering 10,431 cases and 16,687 controls and eight studies of Asian descendants considering 3,590 cases and 15,184 controls.…”

Section: Resultsmentioning

confidence: 99%

“…[1,3,4] In addition, current evidence indicates that PSCA gene variant rs2294008 polymorphism is associated with the risk of bladder cancer. [5,6]…”

Section: Introductionmentioning

confidence: 99%

Contribution of prostate stem cell antigen variation rs2294008 to the risk of bladder cancer

Deng

Ren²,

Jin³

et al. 2019

Medicine

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Objective: Number of studies have been performed to evaluate the relationship between prostate stem cell antigen (PSCA) variation rs2294008 and bladder cancer risk, but the sample size was small and the results were conflicting. This meta-analysis was conducted to comprehensively evaluate the overall association. Methods: Pubmed, Web of science, Embase, China biology medical literature database (CBM), China National Knowledge Infrastructure (CNKI), Wan Fang and Weipu databases were searched before June 30, 2018. The strength of associations was assessed using odds ratios (ORs) and 95% confidence intervals (CIs). All of the statistical analyses were conducted using Review Manager 5.3 and Stata 14.0. Results: Ten studies involved 14,021 cases and 26,871 controls. Overall, significant association was observed between the PSCA gene variant rs2294008 polymorphism and bladder cancer (T vs C: OR = 1.16, 95%CI = 1.12−1.20; TT vs CC: OR = 1.32, 95%CI = 1.24−1.41; TT vs CT+CC: OR = 1.15, 95%CI = 1.09−1.22; TT+CT vs CC: OR = 1.27, 95%CI = 1.21−1.34). In subgroup analysis by ethnic group, a statistically significant association was observed in Asians (T vs C: OR = 1.23, 95%CI = 1.15−1.31) and Caucasians (T vs C: OR = 1.14, 95%CI = 1.10−1.18). The sensitivity analysis confirmed the reliability and stability of the meta-analysis. Conclusion: Our meta-analysis supports that the PSCA gene variant rs2294008 polymorphism might contribute to individual susceptibility to bladder cancer.

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Genetic Variation in PSCA is Associated with Bladder Cancer Susceptibility in a Korean Population

Cited by 8 publications

References 21 publications

Impact of DCC (rs714) and PSCA (rs2294008 and rs2976392) Gene Polymorphism in Modulating Cancer Risk in Asian Population

Impact of DCC (rs714) and PSCA (rs2294008 and rs2976392) Gene Polymorphism in Modulating Cancer Risk in Asian Population

PSCA s2294008 C>T and rs2976392 G>A polymorphisms contribute to cancer susceptibility: evidence from published studies

Contribution of prostate stem cell antigen variation rs2294008 to the risk of bladder cancer

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