Genetic variations in chemoattractant receptor expressed on Th2 cells (CRTH2) is associated with asthma susceptibility in Chinese children

Abstract

We investigated the allele and genotype frequencies of two common CRTH2 single nucleotide polymorphisms (SNPs) [G1544C and A1651G (rs 545659)] in the 3'-untranslated region and the relationship between these SNPs and serum IL-13 levels in Chinese children patients with asthma. For G1544C and A1651G SNPs, there were significant differences in allele and genotype frequencies between asthma patients and controls. Haplotype analysis yielded additional evidence of linkage disequilibrium for the 1544G-1651G haplotype (P < 0.01). Moreover, serum IL-13 levels were significantly different among genotypes in G1544C, A1651G SNPs. These results suggest that SNPs of G1544C and A1651G might be act as susceptibility genetic factors of asthma.

The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2

“…We and others have shown that the CRTh2 single nucleotide polymorphisms (SNPs) rs11571288, rs545659 and rs634681 are associated with asthma and allergic sensitization in ethnically distinct populations . Our previous report also suggested association between CRTh2 rs533116 and allergic asthma, but significance was lost after correcting for multiple comparisons .…”

Genetic variability in CRTH2 polymorphism increases eotaxin‐2 levels in patients with aspirin exacerbated respiratory disease

“…CRTH2 also mediates chemotaxis of Th2 lymphocytes, eosinophils and basophils towards PGD2 (7). There is evidence to suggest that genetic alteration of CRTH2 is related to allergic asthma in African‐American (8) and Chinese populations (8–12). There has been no published data addressing the role of the CRTH2 gene in aspirin exacerbated respiratory disease (AERD) pathogenesis.…”

The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge

“…Genetic variations in CRTH2 have been associated with allergic asthma in different ethnic groups 21–23. Activation of CRTH2 exacerbates allergic inflammation in an allergic inflammatory mouse model of asthma24, while CRTH2 antagonism ameliorates airway inflammation and hyperreactivity in this model 25, 26.…”