Genetic variations of prostate stem cell antigen (PSCA) contribute to the risk of gastric cancer for Eastern Asians: A meta-analysis based on 16792 individuals

Prostate stem cell antigen rs2294008 polymorphism differentially contributes to Helicobacter pylori-negative gastric cancer among various populations in China

“…Another meta-analysis that included eight case-control studies in seven articles comprising 9,738 cases of GC and 7,054 controls indicated that the T allele of rs2294008C>T was significantly associated with increased GC risk [rs2294008C>T: OR (95% CI)=1.31 (1.22-1.42), Pz-test <0.001]. Results of the subgroup analyses indicated that T allele of rs2294008C>T was associated with increased risk of both intestinal and diffuse GC, GC for Eastern Asian (including Chinese, Japanese, Koreans, PCC and HCC/PHCC), cardia and non-cardia GC and GC for males and females (31).…”

PSCA gene variants (rs2294008 and rs2978974) confer increased susceptibility of gallbladder carcinoma in females

“…PSCA is considered to be involved in the cell adhesion (Raff et al, 2009), signal transduction (Matsuo et al, 2009;Qiao and Feng, 2012), cell-proliferation inhibition and/or cell-death induction activity though, its biological functions in carcinogenesis are still obscure (Saeki et al, 2010). PSCA is upregulated (protein or mRNA) in cancer of the prostate (Zhigang and Wenlv, 2004), bladder (Fu et al, 2012), endometrium (Liu et al, 2010) pancreas (Argani et al, 2001), ovary (Cao et al, 2005), central nervous system (Geiger et al, 2011), lung (Kawaguchi et al, 2010) and kidney (Elsamman et al, 2006), etc.…”

“…PSCA, involving either change in protein expression or through association with the polymorphism in the PSCA gene, may act as an oncogene; play a role in tumor progression in some cancers while tumor suppressor gene in others (Saeki et al, 2010;Smith et al, 2012). Genetic variants of PSCA have been found to be strongly associated with the risk for cancers of the breast (Kim et al, 2012), bladder (Rothman et al, 2010), duodenal (Tanikawa et al, 2012) and stomach (Qiao and Feng, 2012) etc. Recently, PSCA has been shown to be involved in GBC development (Ono et al, 2012) and its SNP rs2294008, is also considered a potential genetic risk factor in GBC.…”

Risk estimates for complex disorders: comparing personal genome testing and family history

“…Diffuse stomach cancer was also excluded from analysis because the SNP used by Navigenics for risk estimation has been validated only in the Asian population. 19,20 Information regarding ethnicity was not collected in this study; however, anecdotally Medcan clientele is predominantly of northern European (Caucasian) descent. Finally, obesity was excluded because information regarding family history of obesity was not regularly collected during family history assessments.…”