Genetically Determined ABO Blood Group and its Associations With Health and Disease

Groot, Hilde E.; Sierra, Laura E. Villegas; Said, M. Abdullah; Lipšic, Erik; Karper, J.C.; Harst, Pim van der

doi:10.1161/atvbaha.119.313658

Cited by 118 publications

(134 citation statements)

References 30 publications

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“…ABO blood types of participants were inferred through their genetic profiles. 5 Participants with blood type A had increased odds of at least one positive Covid-19 test relative to blood type O participants (P = 0.003), consistent with the previously-noted association (supplementary eTable 7). 6 However, no significant associations were identified when comparing Covid-19 positive inpatients to positive outpatients.…”

Section: Resultssupporting

confidence: 84%

“…4 Dihydropyridine calcium channel blockers included amlodipine, felodipine, isradipine, nicardipine, and nifedipine. 5 Beta blockers included acebutolol, atenolol, bisoprolol, carvedilol, labetalol, metoprolol, nadolol, nebivolol, pindolol, and propranolol. 6 Thiazolidinediones included rosiglitazone, troglitazone, and pioglitazone.…”

Section: Copyright/license For Publicationmentioning

confidence: 99%

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Clinical and Genetic Characteristics of Covid-19 Patients from UK Biobank

Kolin

Kulm

Elemento

2020

Preprint

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Objective:To explore both clinical and genetic risk factors for Covid-19 in a cohort from the United Kingdom. Design:Prospective cohort study.Participants: 669 positive Covid-19 patients within a cohort of 502,536 UK Biobank participants, recruited between 2006 and 2010. Main Outcome Measures:The main outcome measure was Covid-19 positive status, determined by the presence of any positive test for a single individual. We also assessed risk factors for inpatient and outpatient status for Covid-19 positive individuals. Results:We found that black participants were at over three times increased risk of testing positive for Covid-19, relative to white participants, even after adjusting for confounders (adjusted relative risk [ARR] 3.14, 95% confidence interval [CI] 2.28 to 4.31). Asian participants were also at higher risk of Covid-19 (ARR 2.03, 95% CI 1.40 to 2.95). Next, we analyzed the association of comorbidities with Covid-19. We found that participants were at increased risk of Covid-19 if they had chronic obstructive pulmonary disease (ARR 1.54, 95% CI 1.02 to 2.31) or ischemic heart disease (ARR 1.56, 95% CI 1.18 to 2.07). However, there was no evidence that either angiotensin converting enzyme inhibitors (ARR 1.32, 95% CI 0.95 to 1.84) or angiotensin II receptor blockers (ARR 1.37, 95% CI 0.94 to 1.98) increased the risk of Covid-19. We confirmed that blood type A was associated with Covid-19 relative to blood type O individuals, and we also found that the HLA variant DQA1_509 was enriched in Covid-19 positive cases, even after Bonferroni correction (P = 1.0 x 10 -5 ). Conclusions:In this study, we found that black and Asian participants were at increased risk of Covid-19, even after adjusting for confounders. We also identified a novel genetic association with the HLA variant DQA1_509. Further investigations of genetic associations with Covid-19 may lead to important discoveries of genetic drivers of severe disease.

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Section: Resultssupporting

confidence: 84%

Section: Copyright/license For Publicationmentioning

confidence: 99%

Clinical and Genetic Characteristics of Covid-19 Patients from UK Biobank

Kolin

Kulm

Elemento

2020

Preprint

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“…and a recessive inactive alleles. The association between ABO blood groups and infectious and non-infectious diseases has been widely explored (Groot et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Association Between ABO Blood Group System and COVID-19 Susceptibility in Wuhan

Fan

Zhang

et al. 2020

Front. Cell. Infect. Microbiol.

140

128

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Background: The ABO blood group system has been associated with multiple infectious diseases, including hepatitis B, dengue haemorrhagic fever and so on. Coronavirus disease 2019 (COVID-19) is a new respiratory infectious disease and the relationship between COVID-19 and ABO blood group system needs to be explored urgently. Methods: A hospital-based case-control study was conducted at Zhongnan Hospital of Wuhan University from 1 January 2020 to 5 March 2020. A total of 105 COVID-19 cases and 103 controls were included. The blood group frequency was tested with the chi-square statistic, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated between cases and controls. In addition, according to gender, the studied population was divided into two subgroups, and we assessed the association between cases and controls by gender. Finally, considering lymphopenia as a feature of COVID-19, the relationship between the ABO blood group and the lymphocyte count was determined in case samples. Results: The frequencies of blood types A, B, AB, and O were 42.8, 26.7, 8.57, and 21.9%, respectively, in the case group. Association analysis between the ABO blood group and COVID-19 indicated that there was a statistically significant difference for blood type A (P = 0.04, OR = 1.33, 95% CI = 1.02-1.73) but not for blood types B, AB or O (P = 0.48, OR = 0.90, 95% CI = 0.66-1.23; P = 0.61, OR = 0.88, 95% CI = 0.53-1.46; and P = 0.23, OR = 0.82, 95% CI = 0.58-1.15, respectively). An analysis stratified by gender revealed that the association was highly significant between blood type A in the female subgroup (P = 0.02, OR = 1.56, 95% CI = 1.08-2.27) but not in the male subgroup (P = 0.51, OR = 1.14, 95% CI = 0.78-1.67). The average level of lymphocyte count was the lowest with blood type A in patients, however, compared with other blood types, there was still no significant statistical difference. Conclusions: Our findings provide epidemiological evidence that females with blood type A are susceptible to COVID-19. However, these research results need to be validated in future studies.

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“…For instance, it has been shown that blood type A is a risk factor for gastric cancer [9][10][11] while blood type O is a protective factor for atherosclerosis. [12][13][14] Cardiovascular diseases and cancers impact the lifespan significantly. Thus, the association between ABO blood types and human longevity has naturally been evaluated previously.…”

mentioning

confidence: 99%