Genetically encoded protein sensors for metal ion detection in biological systems: a review and bibliometric analysis

Abstract

Metal ions are indispensable elements in living organisms and are associated with regulating various biological processes.

NeMeHg, genetically encoded indicator for mercury ions based on mNeonGreen green fluorescent protein and merP protein from Shigella flexneri

“…Consequently, the detection of heavy metals in the environment and within living cells is a critical challenge. Among numerous analytical and spectroscopic methods for heavy metal detection, genetically encoded sensors based on fluorescent proteins enable real-time visualization of heavy metal ions in various states: dissolved in solution, attached to cellular membranes, and within the cytoplasm of living cells ( Burdette et al, 2001 ; Mills et al, 2013 ; Chen et al, 2023 ; Torres-Ocampo and Palmer, 2023 ).…”