Genetically engineered M2-like macrophage-derived exosomes for P. gingivalis-suppressed cementum regeneration: From mechanism to therapy

Huang, Xin; Deng, Yifei; Xiao, Junhong; Wang, Huiyi; Yang, Qiudong; Cao, Zhengguo

doi:10.1016/j.bioactmat.2023.10.009

Cited by 5 publications

(2 citation statements)

References 47 publications

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“…Furthermore, we have elucidated multiple molecular mechanisms underlying the inhibition of CB mineralization during periodontitis, including identifying the positive regulatory genes, CXXC5 and miR-181b-5p [110][111][112], and negative regulatory genes, CKIP-1 and miR-155-3p, of CB mineralization [113,114]. Additionally, we have reported on the enhancing effect of M2 macrophages on CB mineralization [115,116].…”

Section: Cementummentioning

confidence: 99%

Mitochondrial Dysfunction in Periodontitis and Associated Systemic Diseases: Implications for Pathomechanisms and Therapeutic Strategies

Deng,

Xiao,

et al. 2024

IJMS

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Periodontitis is a chronic infectious disorder damaging periodontal tissues, including the gingiva, periodontal ligament, cementum, and alveolar bone. It arises from the complex interplay between pathogenic oral bacteria and host immune response. Contrary to the previous view of “energy factories”, mitochondria have recently been recognized as semi-autonomous organelles that fine-tune cell survival, death, metabolism, and other functions. Under physiological conditions, periodontal tissue cells participate in dynamic processes, including differentiation, mineralization, and regeneration. These fundamental activities depend on properly functioning mitochondria, which play a crucial role through bioenergetics, dynamics, mitophagy, and quality control. However, during the initiation and progression of periodontitis, mitochondrial quality control is compromised due to a range of challenges, such as bacterial–host interactions, inflammation, and oxidative stress. Currently, mounting evidence suggests that mitochondria dysfunction serves as a common pathological mechanism linking periodontitis with systemic conditions like type II diabetes, obesity, and cardiovascular diseases. Therefore, targeting mitochondria to intervene in periodontitis and multiple associated systemic diseases holds great therapeutic potential. This review provides advanced insights into the interplay between mitochondria, periodontitis, and associated systemic diseases. Moreover, we emphasize the significance of diverse therapeutic modulators and signaling pathways that regulate mitochondrial function in periodontal and systemic cells.

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Section: Cementummentioning

confidence: 99%

Mitochondrial Dysfunction in Periodontitis and Associated Systemic Diseases: Implications for Pathomechanisms and Therapeutic Strategies

Deng,

Xiao,

et al. 2024

IJMS

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“…163 It can be seen that effective identification of cell markers related to wound healing can provide ideas for precise targeted therapy of exosomes. The extraction methods of exosomes include: density gradient centrifugation (including ultracentrifugation), 164 ultrafiltration, 165 and size exclusion chromatography, 158 etc. At present, mesenchymal stem cells used for exosome research are bone marrow-derived mesenchymal stem cells, embryonicderived mesenchymal stem cells, umbilical cord-derived mesenchymal stem cells, and adipose-derived mesenchymal stem cells, etc.…”

Section: Othersmentioning

confidence: 99%

Novel Biomaterials for Wound Healing and Tissue Regeneration

Zhong,

Wei,

et al. 2024

ACS Omega

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Skin is the first defense barrier of the human body, which can resist the invasion of external dust, microorganisms and other pollutants, and ensure that the human body maintains the homeostasis of the internal environment. Once the skin is damaged, the health threat to the human body will increase. Wound repair and the human internal environment are a dynamic process. How to effectively accelerate the healing of wounds without affecting the internal environment of the human body and guarantee that the repaired tissue retains its original function as much as possible has become a research hotspot. With the advancement of technology, researchers have combined new technologies to develop and prepare various types of materials for wound healing. This article will introduce the wound repair materials developed and prepared in recent years from three types: nanofibers, composite hydrogels, and other new materials. The paper aims to provide reference for researchers in related fields to develop and prepare multifunctional materials. This may be helpful to design more ideal materials for clinical application, and then achieve better wound healing and regeneration effects.

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Exosomes and Macrophages: Bidirectional Mutual Regulation in the Treatment of Diabetic Complications

Li,

Yang,

et al. 2024

Cel. Mol. Bioeng.

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Genetically engineered M2-like macrophage-derived exosomes for P. gingivalis-suppressed cementum regeneration: From mechanism to therapy

Cited by 5 publications

References 47 publications

Mitochondrial Dysfunction in Periodontitis and Associated Systemic Diseases: Implications for Pathomechanisms and Therapeutic Strategies

Mitochondrial Dysfunction in Periodontitis and Associated Systemic Diseases: Implications for Pathomechanisms and Therapeutic Strategies

Novel Biomaterials for Wound Healing and Tissue Regeneration

Exosomes and Macrophages: Bidirectional Mutual Regulation in the Treatment of Diabetic Complications

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