2022
DOI: 10.21203/rs.3.rs-2074299/v1
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Genetically engineered macrophage membrane-coated nanoparticles for enhanced tumor targeting and synergistic cancer therapy

Abstract: The poor targeting capability of systemically administered drugs is a major hurdle in designing effective therapies with minimal off-target side effects. Here, as a proof of concept, we propose a genetic engineering strategy to embed a prostate-specific membrane antigen (PSMA)-targeting antibody fragment (gy-1) in the macrophage membrane, which is then coated onto core-shell Fe3O4@Au nanoparticles to produce a biomimetic nanoplatform, Magic. The results indicate that Magic exhibits not only high specificity an… Show more

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