Genetically Engineered Mesenchymal Stem Cells

Shah, Khalid

doi:10.1016/b978-0-12-416606-6.00001-5

Cited by 2 publications

(4 citation statements)

References 163 publications

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“…The significant issues of current treatments are the short half-life of cancer therapeutics, their limited delivery to the tumor site, and their adverse effects on normal organs. Many researchers have focused on applying stem and progenitor cells to address these issues . Among the outstanding capabilities of stem cells are self-renewal without differentiation as well as differentiation to many cell types after receiving the required stimulants .…”

Section: Applications Of Cell Encapsulation As Cellular Implantsmentioning

confidence: 99%

“…In 3D cell growth, several genes are actively expressed, leading to increased secreted levels of growth factors, anti-inflammatory molecules, cytokines, and antitumor molecules. In vivo transplantation and in vivo cell retention would be made more accessible through encapsulation, which provides a physiologic 3D environment that promotes cell survival and prevents immune response. ,, …”

Section: Applications Of Cell Encapsulation As Cellular Implantsmentioning

confidence: 99%

“…Many researchers have focused on applying stem and progenitor cells to address these issues. 74 Among the outstanding capabilities of stem cells are self-renewal without differentiation as well as differentiation to many cell types after receiving the required stimulants. 75 Stem cells are the natural source of embryogenetic and continuous tissue regeneration.…”

Section: Cellular Implants Formentioning

confidence: 99%

“…In vivo transplantation and in vivo cell retention would be made more accessible through encapsulation, which provides a physiologic 3D environment that promotes cell survival and prevents immune response. 74,88,89 Using a scaffold-based delivery system, Reagan et al showed sustained release of therapeutic MSCs capable of expressing genetically engineered TRAILs (TNF-related apoptosis-inducing ligand). TRAIL-expressing MSCs with doxycyclineinduced promoters were embedded in porous, biocompatible silk scaffolds and delivered to mice in different ways.…”

Section: Cellular Implants Formentioning

confidence: 99%

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Cell Encapsulation and 3D Bioprinting for Therapeutic Cell Transplantation

Samadi¹,

Moammeri

Pourmadadi

et al. 2023

ACS Biomater. Sci. Eng.

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The promise of cell therapy has been augmented by introducing biomaterials, where intricate scaffold shapes are fabricated to accommodate the cells within. In this review, we first discuss cell encapsulation and the promising potential of biomaterials to overcome challenges associated with cell therapy, particularly cellular function and longevity. More specifically, cell therapies in the context of autoimmune disorders, neurodegenerative diseases, and cancer are reviewed from the perspectives of preclinical findings as well as available clinical data. Next, techniques to fabricate cellbiomaterials constructs, focusing on emerging 3D bioprinting technologies, will be reviewed. 3D bioprinting is an advancing field that enables fabricating complex, interconnected, and consistent cell-based constructs capable of scaling up highly reproducible cell-biomaterials platforms with high precision. It is expected that 3D bioprinting devices will expand and become more precise, scalable, and appropriate for clinical manufacturing. Rather than one printer fits all, seeing more application-specific printer types, such as a bioprinter for bone tissue fabrication, which would be different from a bioprinter for skin tissue fabrication, is anticipated in the future.

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Section: Applications Of Cell Encapsulation As Cellular Implantsmentioning

confidence: 99%

Section: Applications Of Cell Encapsulation As Cellular Implantsmentioning

confidence: 99%

Section: Cellular Implants Formentioning

confidence: 99%

Section: Cellular Implants Formentioning

confidence: 99%

See 2 more Smart Citations

Cell Encapsulation and 3D Bioprinting for Therapeutic Cell Transplantation

Samadi¹,

Moammeri

Pourmadadi

et al. 2023

ACS Biomater. Sci. Eng.

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Disease Modifying Potential of Glatiramer Acetate in Huntington's Disease

Corey–Bloom

Jia

Aikin

et al. 2014

Journal of Huntington's Disease

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Background: Deficiencies in brain-derived-neurotrophic-factor have been implicated in the pathogenesis of Huntington's disease (HD). Objective: Glatiramer acetate, an FDA-approved drug used for the treatment of multiple sclerosis, has been shown to increase brain-derived-neurotrophic-factor levels in immune cells; hence, we investigated whether it could have similar effects in striatal cells. Methods: Wild-type and HD striatal cells were treated with glatiramer acetate for 48 hrs. HD transgenic and wild-type mice were injected with glatiramer acetate (1.5 to1.7 mg/mouse) for five days. These treatments were followed by protein measurements for brain-derived-neurotrophic-factor. Results: Glatiramer acetate elicited concentration-dependent increases in brain-derived-neurotrophic-factor protein levels in wild-type and HD striatal cells and in striatal tissue from N171-82Q transgenic mice. Glatiramer acetate also improved metabolic activity of HD striatal cells, and significantly reduced the early hyperactivity phenotype exhibited by N171-82Q transgenic mice. Conclusions: These findings suggest that glatiramer acetate may represent a useful therapeutic approach for HD. The excellent safety and tolerability record of this compound makes it an ideal candidate for drug repurposing efforts.

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Genetically Engineered Mesenchymal Stem Cells

Cited by 2 publications

References 163 publications

Cell Encapsulation and 3D Bioprinting for Therapeutic Cell Transplantation

Cell Encapsulation and 3D Bioprinting for Therapeutic Cell Transplantation

Disease Modifying Potential of Glatiramer Acetate in Huntington's Disease

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