Genetically Modified Baculoviruses for Pest Insect Control

Kamita, Shizuo G.; Kang, Kyung-Don; Hammock, Bruce D.; Inceoglu, Bora

doi:10.1016/b0-44-451924-6/00085-5

Cited by 27 publications

(21 citation statements)

References 319 publications

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“…128,129) Baculoviruses, highly selective DNA viruses for lepidopteran pest insects, have been genetically modified to accelerate the speed to kill host insects, and the expression of genes coding JHE and various peptide neurotoxins has been reported as a potential biological insecticide. 130,131) Recombinant Sindbis viruses also have proved to be effective as an ectopic-gene expressing system in insects, especially in mosquitoes 132) and in lepidopteran imaginal discs. 133,134) These virus-mediated transgenic systems can be used only for limited species because of their host specificity.…”

Section: Potential Use Of Recombinant Dna Techniquesmentioning

confidence: 99%

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Insect juvenile hormone action as a potential target of pest management

Minakuchi

Riddiford

2006

J. Pestic. Sci.

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Juvenile hormone (JH) is a sesquiterpenoid hormone that regulates growth and development in insects. Since JH is a hormone specific to insects and other arthropods, compounds disrupting JH action in insects are expected to be ideal insecticides with low toxicity to non-target organisms. Many natural or synthetic analogs with JH-like or anti-JH activity have been identified, and some potent JH mimics have been used as insecticides. Recent studies on the enzymes in JH biosynthetic and metabolic pathways should be helpful for the discovery of more potent analogs and for the establishment of new means of pest management using recombinant DNA technology. © Pesticide Science Society of Japan Keywords: juvenile hormone (JH), insect metamorphosis, insect growth regulators, biosynthesis and metabolism of JH. Review* To whom correspondence should be addressed. E-mail: chieka_minakuchi@yahoo.com © Pesticide Science Society of Japan doptera. 17,18) Higher Diptera such as D. melanogaster and the blowfly Calliphora vomitoria produce JH III bisepoxide. 19,20) A small amount of methyl farnesoate, a precursor of JH III, was found in cockroach embryos and larvae. [20][21][22] Methyl farnesoate has also been identified in crustaceans 23) and is thought to have a JH-like action in female reproduction. 24)12Ј-OH JH III identified from the corpora allata of the African locust Locusta migratoria migratorioides was reported to exhibit JH activity when a high dose of this compound was topically applied to Tenebrio pupae. 25,26) Biosynthesis, Transport and Metabolism of Juvenile HormoneIn insects, JH is synthesized in the corpora allata via the mevalonate pathway (Fig. 2).27) The mevalonate pathway also exists in mammals and plants, and the early steps from acetylCoA to farnesyl diphosphate are conserved among these organisms. Importantly, insects and other arthropods do not synthesize cholesterol de novo but have to acquire it from dietary sources because they lack the genes encoding squalene synthase and other subsequent enzymes of the sterol branch. 28,29) Another peculiarity of the mevalonate pathway in insects is the capacity to synthesize JH via the isoprenoid branch.The genes encoding the enzymes in the mevalonate pathway from acetyl-CoA to farnesyl diphosphate have been identified in the genome of D. melanogaster and the malaria mosquito Anopheles gambiae, and in an EST library of the pine engraver Ips pini.27) However, it has been difficult to identify the genes encoding enzymes from farnesyl diphosphate to JH

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Section: Potential Use Of Recombinant Dna Techniquesmentioning

confidence: 99%

“…In addition, if delivery is via genetically modified baculovirus, there will be additional concern about the safety of the virus. 130,131) Therefore, public education about the benefits of these new approaches is essential so that they can be included as methods in integrated pest management in the future.…”

Section: Potential Use Of Recombinant Dna Techniquesmentioning

confidence: 99%

Insect juvenile hormone action as a potential target of pest management

Minakuchi

Riddiford

2006

J. Pestic. Sci.

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“…More than 30 recombinant baculoviruses have been constructed with the specific goal of enhancing the insecticidal properties of the virus (Kamita et al, 2005). Most of these viruses have been constructed to reduce the time taken by the virus to kill the host insect, though genetic manipulation of baculovirus host range, and improvement of virus stability have also received some attention (Bonning and Nusawardani, 2007).…”

Section: Genetic Enhancement Of Baculovirus Insecticidesmentioning

confidence: 99%

“…Recombinant baculoviruses expressing genes that encode a variety of insect-specific toxins or development-disrupting enzymes and hormones kill insects more rapidly and reduce feeding damage compared with larvae infected with wild-type baculoviruses (Kamita et al, 2005). Strategies used for genetic enhancement have included deletion of specific viral genes to enhance pesticide efficacy and genetic engineering of the virus genome to express genes encoding insect hormones, enzymes, and insect-specific toxins (Harrison and Bonning, 2000a;van Beek and Hughes, 1998).…”

Section: Genetic Enhancement Of Baculovirus Insecticidesmentioning

confidence: 99%

“…Although baculoviruses have potential for insect pest control, they have not been widely used in part because they are poorly competitive with chemical pesticides in terms of speed of action. Recombinant baculoviruses expressing neurotoxins, enzymes, and insect peptide hormones have been constructed for enhanced insecticidal efficacy (Kamita et al, 2005;van Beek and Hughes, 1998).…”

Section: Thesis Organizationmentioning

confidence: 99%

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Tissue specificity of a baculovirus-expressed, basement membrane-degrading protease in larvae of Heliothis virescens

Tang

Lei

et al. 2007

Tissue and Cell

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Effect of fluorescent brighteners on the insecticidal activity of Bacillus thuringiensis var. kurstaki and LdMNPV on Lymantria dispar asiatica in Korea

Mezione de Carvalho,

Hwang,

Lee

2023

Arch Insect Biochem Physiol

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Stilbene‐based fluorescent brighteners (FBs) have been demonstrated to improve the insecticidal activities of entomopathogenic viruses; however, there is limited information regarding their effect on entomopathogenic bacteria. We conducted this study to investigate the effect of two FBs (FB 28 and FB 71) on the insecticidal activities of Bacillus thuringiensis var. kurstaki (Btk) and Lymantria dispar multiple nuclear polyhedrosis virus (LdMNPV) on Lymantria dispar asiatica. FB 28 and Btk combination at low concentration (1.6 × 102 IU/mL) increased the mortality, whereas FB 71 and Btk combination at intermediate and high concentrations (1.6 × 103 and 1.6 × 104 IU/mL) slightly reduced the mortality compared with that with Btk alone. The lethal time was also shorter with combinations of Btk and FB 28 than with FB 71. Both FB 28 and FB 71 increased the mortality in combination with LdMNPV at all concentrations (3 × 102, 3 × 104, and 3 × 106 polyhedral occlusion bodies/mL compared with that with LdMNPV alone. Our results suggest that FBs improve the insecticidal activities of Btk and LdMNPV, and their activities depend on their interactions with the midgut structures of the host insect species.

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Genetically Modified Baculoviruses for Pest Insect Control

Cited by 27 publications

References 319 publications

Insect juvenile hormone action as a potential target of pest management

Insect juvenile hormone action as a potential target of pest management

Tissue specificity of a baculovirus-expressed, basement membrane-degrading protease in larvae of Heliothis virescens

Effect of fluorescent brighteners on the insecticidal activity of Bacillus thuringiensis var. kurstaki and LdMNPV on Lymantria dispar asiatica in Korea

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