Genetically Modified Humans: The X-Men of Scientific Research

Straiton, Jenny

doi:10.2144/btn-2019-0056

Cited by 6 publications

(5 citation statements)

References 10 publications

(11 reference statements)

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“…When it comes to precisely altering specific genomic regions or editing longer DNA sequences, it has some limits. [33] Scientists are constantly researching new delivery systems, exploring alternative genome editing technologies, enhancing the specificity and precision of CRISPR/Cas9, as well as the ethical and societal consequences of this potent technology. Nevertheless, the developments brought about by the HGP have catapulted genetic engineering into a new era of revolutionary possibilities, with significant consequences for scientific research and human health.…”

Section: Advancements In Genetic Engineeringmentioning

confidence: 99%

A brief overview of game-changing genetic engineering projects

Khan,

Roy

2023

J Bio-X Res

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In recent era, advancement of research involves computational management of large-scale genomic and post-genomic datasets in an obvious way. Rapidly emerging field of bioinformatics, fueled by high-throughput technologies and genomic scale database, is believed to reshape our approach of research to a new level. Genomics has shifted the paradigm of biological perspectives exploring many scopes. Old initiatives paved the path for the newer and more advantageous one. The present review focuses on present initiatives that are implemented till now like the famous Human Genome Project and its influence on digital biology, as well as the projects that followed in its footsteps. Additionally, the authors delve into the future potential of personalized medicine and the use of genetic engineering methods like CRISPR/Cas9 in gene editing, which are thought to have the potential to revolutionize the current treatment strategy.

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Section: Advancements In Genetic Engineeringmentioning

confidence: 99%

A brief overview of game-changing genetic engineering projects

Khan,

Roy

2023

J Bio-X Res

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“…Therapeutic applications of CRISPR are on the rise. Technology plays an essential role in exploring potential therapies for various genetic diseases through direct modification of the genome ( Straiton, 2019 ).…”

Section: Application Of Crispr In Sars-cov-2 Treatmentmentioning

confidence: 99%

CRISPR Technology in Gene-Editing-Based Detection and Treatment of SARS-CoV-2

Shademan

Nourazarian

Hajazimian

et al. 2022

Front. Mol. Biosci.

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Outbreak and rapid spread of coronavirus disease (COVID-19) caused by coronavirus acute respiratory syndrome (SARS-CoV-2) caused severe acute respiratory syndrome (SARS-CoV-2) that started in Wuhan, and has become a global problem because of the high rate of human-to-human transmission and severe respiratory infections. Because of high prevalence of SARS-CoV-2, which threatens many people worldwide, rapid diagnosis and simple treatment are needed. Genome editing is a nucleic acid-based approach to altering the genome by artificially changes in genetic information and induce irreversible changes in the function of target gene. Clustered, regularly interspaced short palindromic repeats (CRISPR/Cas) could be a practical and straightforward approach to this disease. CRISPR/Cas system contains Cas protein, which is controlled by a small RNA molecule to create a double-stranded DNA gap. Evidence suggested that CRISPR/Cas was also usable for diagnosis and treatment of SARS-CoV-2 infection. In this review study, we discoursed on application of CRISPR technology in detection and treatment of SARS-CoV-2 infection. Another aspect of this study was to introduce potential future problems in use of CRISPR/Cas technology.

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“…Therapeutic applications for CRISPR are on the rise, with the technology playing a key role in the development of potential cures for a variety of genetic diseases by directly editing the genome [12]. Meanwhile, taking a different approach and looking outside the human genome, researchers from Stanford University (CA, USA) are working towards a CRISPR-based therapeutic for infectious disease.…”

Section: Pac-man Vs the Pandemic: Therapeutics Going Retromentioning

confidence: 99%