Genetically modified potato and rice based edible vaccines – An overview

Gupta, Pranjali; Andankar, Isha; Bharath, Gunasekaran; Nalini, E; Gothandam, Kodiveri Muthukaliannan

doi:10.1016/j.bcab.2022.102405

Cited by 3 publications

(1 citation statement)

References 84 publications

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“…These innovative vaccines have some advantages over classical vaccines, including the long-term preservation of antigenic proteins without the need for a cold chain, resistance to digestion in the stomach, lower cost, increased safety, and scalability (269). Potato, tomato, and rice are attractive antigenexpressing plants that have been used as a platform for the development of candidate vaccines against some infectious diseases in animals and humans (269)(270)(271). Notably, the expression of CTX-B subunit oligomers has been reported in transgenic potato (272), tomato (273,274), and rice plants (275,276).…”

Section: Vaccines Candidates In Clinical Developmentmentioning

confidence: 99%

Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development

et al. 2023

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Vibrio cholerae is the causative agent of cholera, a highly contagious diarrheal disease affecting millions worldwide each year. Cholera is a major public health problem, primarily in countries with poor sanitary conditions and regions affected by natural disasters, where access to safe drinking water is limited. In this narrative review, we aim to summarize the current understanding of the evolution of virulence and pathogenesis of V. cholerae as well as provide an overview of the immune response against this pathogen. We highlight that V. cholerae has a remarkable ability to adapt and evolve, which is a global concern because it increases the risk of cholera outbreaks and the spread of the disease to new regions, making its control even more challenging. Furthermore, we show that this pathogen expresses several virulence factors enabling it to efficiently colonize the human intestine and cause cholera. A cumulative body of work also shows that V. cholerae infection triggers an inflammatory response that influences the development of immune memory against cholera. Lastly, we reviewed the status of licensed cholera vaccines, those undergoing clinical evaluation, and recent progress in developing next-generation vaccines. This review offers a comprehensive view of V. cholerae and identifies knowledge gaps that must be addressed to develop more effective cholera vaccines.

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Section: Vaccines Candidates In Clinical Developmentmentioning

confidence: 99%

Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development

et al. 2023

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Plant‐Made Vaccines Targeting Enteric Pathogens—Safe Alternatives for Vaccination in Developing Countries

Trujillo,

Angulo

2024

Biotech & Bioengineering

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Enteric diseases by pathogenic organisms are one of the leading causes of death worldwide, particularly in low‐income countries. Despite antibiotics, access to clean water and vaccination are the most economically affordable options to prevent those infections and their health consequences. Vaccines, such as those approved for rotavirus and cholera, have played a key role in preventing several enteric diseases. However, vaccines for other pathogens are still in clinical trials. Distribution and cost remain significant barriers to vaccine access in developing regions due to poor healthcare infrastructure, cold‐chain requirements, and high production costs. Plant‐made vaccines offer a promising alternative to address these challenges. Plants can be easily grown, lowering production costs, and can be administered in oral forms, potentially eliminating cold‐chain dependency. Although there are some promising prototypes of vaccines produced in plants, challenges remain, including yields and achieving sufficient immunogenicity. This review aims to describe common enteric pathogens and available vaccines, followed by a strategic summary of plant‐made vaccine development and a discussion of plant‐made enteric vaccine prototypes. Trends to overcome the key challenges for plant‐made vaccines are identified and placed in perspective for the development of affordable and effective vaccines for populations at the highest risk of enteric diseases.

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A Simple Narrative Review of Progress on the Processing and Utilization of Functional Rice

Yi,

Chen,

Zhou

et al. 2024

Foods

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This paper aims to review the research progress on the processing and utilization of functional rice and explore its potential to enhance human health. The research progress in the processing and utilization of colored rice, low-protein rice, high-resistant starch rice, micronutrient-enriched rice, and bioreactor rice was systematically analyzed through a comprehensive literature review. The impact of various processing techniques on the retention of nutritional components in functional rice was also discussed. This study found that functional rice exhibits great potential in terms of nutritional value, health effects, and market demand. However, issues such as the loss of bioactive components during processing, the maintenance of specific agronomic traits, and market acceptance still need to be addressed. The research and development of functional rice are significant for enriching people’s dietary choices and addressing global malnutrition and chronic disease problems. Future efforts should focus on further optimizing processing techniques and utilizing genetic engineering and molecular breeding technologies to enhance the nutritional value and agronomic traits of functional rice, thus meeting market demands and health objectives.

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Genetically modified potato and rice based edible vaccines – An overview

Cited by 3 publications

References 84 publications

Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development

Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development

Plant‐Made Vaccines Targeting Enteric Pathogens—Safe Alternatives for Vaccination in Developing Countries

A Simple Narrative Review of Progress on the Processing and Utilization of Functional Rice

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