Genetics and osteoarthritis: Exposing the iceberg

Holderbaum, Daniel; Haqqi, Tariq M.; Moskowitz, Roland W.

doi:10.1002/1529-0131(199904)42:3<397::aid-anr1>3.0.co;2-x

Cited by 70 publications

(31 citation statements)

References 67 publications

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“…1,7,21,23 Increased bone density in patients with osteoarthritis may be associated with increased skeletal concentrations of insulin-like growth factor (IGF)-I, IGF-II, and transforming growth factor (TGF)-␤. 1 Genes for vitamin D receptor, estrogen receptor, collagen I␣1, calcitonin receptor, peroxysome proliferator-activated receptor-␥, Heremans Schmidt-glycoprotein, and TGF␤1, have been associated with bone density.…”

Section: Discussionmentioning

confidence: 99%

“…21 Furthermore, mutations or polymorphisms in several genes encoding Type II procollagen, Type XI collagen, the vitamin D receptor, IGF-I, and TGF-␤ were associated with osteoarthritis. 7 In addition, Ogata et al 23 recently suggested that the Werner helicase gene may be a candidate for the genetic regulation of osteoporosis, but not spondylosis. With regard to intervertebral disc degeneration, Videman et al 32 reported that vitamin D receptor alleles are associated with intervertebral disc degeneration, as evaluated by magnetic resonance imaging.…”

Section: Discussionmentioning

confidence: 99%

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Inverse Relation Between Osteoporosis and Spondylosis in Postmenopausal Women As Evaluated by Bone Mineral Density and Semiquantitative Scoring of Spinal Degeneration

Miyakoshi

Itoi

Murai

et al. 2003

Spine

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Significant negative correlations were found between all bone mineral density data and the number of vertebral fractures (-0.524 < or r= r < or = -0.347; P < 0.05). Marginal/moderate positive correlations were observed between the osteophyte score and the bone mineral density data (0.263 < or = r < or = 0.580, P < 0.05), and between the disc score and the bone mineral density data (0.233 < or = r < or = 0.570, P < 0.05).CONCLUSIONS On the basis of the finding that spondylotic changes in postmenopausal women exhibit positive correlations not only with the lumbar bone mineral density, but also with the remote-site bone mineral density, this study supports the view that osteoporosis has an inverse relation with spondylosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inverse Relation Between Osteoporosis and Spondylosis in Postmenopausal Women As Evaluated by Bone Mineral Density and Semiquantitative Scoring of Spinal Degeneration

Miyakoshi

Itoi

Murai

et al. 2003

Spine

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“…A mutation in this gene which is located on chromosome 12 (12q13-14) has been associated with the development of OA in Stickler's syndrome. 9 Candidate gene studies looking for associations between genetic variations of aggrecanase 10 and metalloproteinase (e.g. ADAMTS-5) 11 have failed to demonstrate any significant genetic associations.…”

Section: Introductionmentioning

confidence: 99%

(i) The pathobiology of osteoarthritis

Swales

Athanasou

2010

Orthopaedics and Trauma

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“…OA has a strong genetic component, and several susceptibility genes for OA have been reported. Heredity will become a substantial factor in future considerations of diagnosis and treatment for OA (Holderbaum et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility

et al. 2007

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A genetic association of knee osteoarthritis (OA) and a C/T transition single nucleotide polymorphism (SNP) (rs912428) located in intron 1 of the LRCH1 gene has recently been reported in European Caucasians; however, the results are inconsistent. Our objective was to evaluate the association in different knee OA populations. Three case-control association studies were conducted in Han Chinese, Japanese, and Greek Caucasian populations. The LRCH1 SNP was genotyped in patients who had primary symptomatic knee OA with radiographic confirmation and in matched controls, and the association was examined. We performed a meta-analysis for the studies together with results of two previous papers using the DerSimonian-Laird procedure and calculated the power of the pooled studies by the software R. A total of 1,145 OA patients and 1,266 controls were genotyped. No significant difference was detected in genotype or allele frequencies between knee OA and control groups in the three populations (all P [ 0.05). Association was not observed even after stratification by gender and Kellgren/Lawrence (K/L) scores. Meta-analysis also supported the lack of association between LRCH1 and knee OA. The strong heterogeneity between original and replication studies was detected in Caucasian populations. However, a tendency for the increase of TT genotype was observed in the European populations (OR = 1.46, P = 0.06). The powers for European and Asian replication studies were less than 0.8. Our results suggest that there is no association between LRCH1 and knee OA. However, lack of association should be concluded by further replication studies.

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Genetics and osteoarthritis: Exposing the iceberg

Cited by 70 publications

References 67 publications

Inverse Relation Between Osteoporosis and Spondylosis in Postmenopausal Women As Evaluated by Bone Mineral Density and Semiquantitative Scoring of Spinal Degeneration

Inverse Relation Between Osteoporosis and Spondylosis in Postmenopausal Women As Evaluated by Bone Mineral Density and Semiquantitative Scoring of Spinal Degeneration

(i) The pathobiology of osteoarthritis

Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility

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