Genetics and specific immune response in allergy to birch pollen and food: Evidence of a strong, positive association between atopy and the HLA class II allele HLA-DR7☆☆☆★

Polymorphism in the STAT6 gene encodes risk for nut allergy

“…6,23 Previous studies have provided evidence for association between susceptibility to allergy (with or without asthma-related symptoms), and HLA-DR4 and/or the DR7 allele. 24 Howell et al 25 have also demonstrated significant increase in HLA-DRB1*08, and the DQB1*04 allele in peanut allergy patients.…”

Hygiene factors associated with childhood food allergy and asthma

“…Regarding a food allergy diagnosis, although children were not food challenged, the definition of food allergy for this study was more stringent than most published large-scale epidemiologic studies of food allergy. [23][24][25][26][27] A unique strength of this study was that families of children with food allergy were enrolled along with their siblings, who may or may not had allergic diagnoses. The subjects and controls were of similar genetic makeup and were raised similarly.…”

HLA–DRB4 as a genetic risk factor for Churg‐Strauss syndrome

“…Some vasculitides are also associated with such HLA alleles: giant cell arteritis is significantly associated with HLA-DRB1*04 (14). HLA-DRB1*04 and (to a lesser extent) HLA-DRB1*07 have been found to be associated with atopy (37,38), but these results were not corroborated in other investigations (39). Finally, an HLA profile strikingly similar to that observed in CSS (i.e., increased HLA-DRB4 and reduced HLA-DRB3 frequency) has been found in childhood acute lymphoblastic leukemia (40).…”