Genetics of headache in children: Where are we headed?

Hershey, Andrew D.

doi:10.1007/s11916-008-0062-x

Cited by 5 publications

(3 citation statements)

References 44 publications

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“…Last but not the least, Hershey has begun studying genetic patterns in youngsters with headache and hopes to predict who will get better based on his or her genetics.…”

Section: Historic Articlesmentioning

confidence: 99%

Pediatric Headache: Where Have We Been and Where Do We Need to Be

2014

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“…Last but not the least, Hershey has begun studying genetic patterns in youngsters with headache and hopes to predict who will get better based on his or her genetics.…”

Section: Historic Articlesmentioning

confidence: 99%

Pediatric Headache: Where Have We Been and Where Do We Need to Be

2014

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“…The results demonstrated a lack of occurrence of the common mutations in adolescents as a comorbidity factor. Given the potential of the genetics in the expression of primary headaches in children, there is an expectation that genetic factors and polymorphisms will be identified 40 . The complexity of primary headaches and the potential of multiple genes make this task more difficult, but with new polymorphism gene chips, this has an increased possibility of identification.…”

Section: Genetics and Molecular Biologymentioning

confidence: 99%

Pediatric Headache: Update on Recent Research

Hershey

2012

Headache

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Primary headache are one of the most common health complaints in children and adolescents, yet there remain significant gaps in our understanding of the underlying pathophysiology of these conditions. Recently, there have been several areas of research that have assisted with filling this gap in our knowledge. These areas include a better understanding of the disease characteristics including additional associated symptoms and the refinement of the description of related conditions and comorbidities; continued examination of the epidemiology of primary headaches; the progression of migraine across these developmental ages; the molecular and physiological changes; and the potential role for vitamins and cofactor deficiencies in the pathophysiology. These studies continue to add to our fund of knowledge on the basis of migraine and tension-type headache as primary neurological conditions and their impact on the developing brain.

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“…Recurrent headache seem to be a complex disorder caused by influence of multiple genes and environmental factors (MONTAGNA et al 2010;SCHURKS 2008;BASBAUM et al 2009;CREGG et al 2010). No empirical study has explicitly examined how genetic and environmental factors influence the recurrent headache (DE VRIES et al 2008;MONTAGNA 2008; VAN DEN MAAGDENBERG 2010;HERSHEY 2008).…”

Section: Introductionmentioning

confidence: 99%

Recurrent headache and migraine heritability: Twin study

Knezevic-Pogancev

2011

Genetika

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The aim of the study was to determine recurrent headache (migraine and non-migraine) heritability, among the twin pairs. Headache hritability was investigated among 396 twin pairs (42.4% monozygotic and 57.6% dizygotic) aged 3 to 21 years, on north part territory of Serbia-Vojvodina, during the 20 years period. Within the group of tested twin persons, 30.2% had recurrent headaches, 9.2% migraine headache and 21% other recurrent non-migraine headaches. Heritability quotient of all recurrent headaches was 0.3882. For non- migraine headaches heritability quotient of 0.2286 confirmed that the external factors influence is higher than heritability. Migraine headache heritability quotient 0.8598 clearly proved the heritability of the migraine headache. Both, correlation and determination quotient of the migraine headache of all the twins (r12 0.7498; r21256.12%), monozygotic (r120.8458; r1271.54%) and dizygotic (r120.6342; r21240.22%), show high degree of migraine headache twin siblings dependence, and higher correlation and significance of the difference with monozygotic twins

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Genetics of headache in children: Where are we headed?

Cited by 5 publications

References 44 publications

Pediatric Headache: Where Have We Been and Where Do We Need to Be

Pediatric Headache: Where Have We Been and Where Do We Need to Be

Pediatric Headache: Update on Recent Research

Recurrent headache and migraine heritability: Twin study

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