Genetics: Pet project

Cyranoski, David

doi:10.1038/4661036a

Cited by 14 publications

(4 citation statements)

References 12 publications

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“…Furthermore, behavioral genetic studies have shown that most human psychological traits, such as the Five Factor Model, are substantially heritable [e.g., 30], with no or very small familial (shared) environmental influences [12,24,33]. There is a large interest in dog behavioral genetics, which would reveal the human psychological trait mechanisms [4]. In addition, analyzing the data obtained from C-BARQ revealed clear breed differences regarding behavior [6,10,27,32].…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Factorial Structures of the C-BARQ in Japan

Nagasawa

Tsujimura

Tateishi

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. In order to introduce the Canine Behavioral Assessment and Research Questionnaire (C-BARQ), which is a standardized system for evaluating the behavioral traits of dogs, to Japan, where the environment with respect to dog ownership is thought to differ from those of the United States and Europe, we compared demographic information on dogs in the United States and Japan and examined whether similar factors could be extracted from both countries using questionnaire items of the C-BARQ. The C-BARQ was completed by 11,410, and 734 dog owners respectively in the United States and Japan, and some demographic differences were found, such as breed and neuter status. Data from completed questionnaires were subjected to factor analysis, and the resulting factors were tested for reliability. In the United States, factor analysis yielded 11 factors from 63 items that accounted for 52.9% of the common variance. In Japan, 15 factors were extracted, and these accounted for 57.0% of the common variance. The present factors for the United States were almost identical to the factors identified in a previous study, and similar factors were extracted in both countries. Therefore, the C-BARQ can function effectively as a fundamental behavioral evaluation system for dogs in Japan.KEY WORDS: behavior, canine, C-BARQ, factor analysis, questionnaire.J. Vet. Med. Sci. 73 (7): [869][870][871][872][873][874][875] 2011 In the United States and Europe, behavior problems of dogs account for 17-20% of reasons that owners relinquish their pet dogs to animal shelters, and substantial numbers of these dogs are eventually euthanized [2,5,19,23,25]. In addition, many dogs suffer unnecessarily from inappropriate punishments and aversive training methods as a consequence of behavior problems [8]. These inappropriate treatments for dogs often worsen the problems and create a vicious cycle. In Japan, there were an estimated 13,101,000 pet dogs in 2008 [13]. Of these, 105,195 adult dogs and 24,742 puppies were relinquished to animal shelters [20]. Additional estimates suggest that 29,942 of these dogs were either returned to their owners or adopted by new owners, while 98,556 dogs were eventually euthanized. Because official research has not been conducted yet, it is not known exactly why these dogs were relinquished [20]. In order to resolve these issues, it is important to establish a system for classifying and naming behavioral traits in dogs. Researchers in the United States and Europe have developed some behavioral tests to evaluate the behavioral traits of dogs [14,21,28,30]; however, it is not easy to conduct these behavioral tests, and the possibility exits that the emergence of particular behaviors may be dependent on experimental circumstances during the test. On the other hand, observer ratings can be convenient and useful tools through careful experimental designs [18]. However, observation by third parties has the practical difficulty of observing pet dogs in their natural and home environment. Therefore, in order to understand ...

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Section: Discussionmentioning

confidence: 99%

Assessment of the Factorial Structures of the C-BARQ in Japan

Nagasawa

Tsujimura

Tateishi

et al. 2011

The Journal of Veterinary Medical Science

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“…An animal model may be helpful in unravelling its mechanism of action. The dog is considered to be a valuable animal model for several human psychiatric conditions [ 20 , 21 ] . Not only because dogs exhibit naturally occurring behavioural disorders that are homologues to certain human psychiatric conditions [ 20 ] , but also since several functional imaging studies demonstrated similar changes in neuronal activity and cerebral blood flow.…”

Section: Introductionmentioning

confidence: 99%

The influence of subanaesthetic ketamine on regional cerebral blood flow in healthy dogs measured with 99mTc-HMPAO SPECT

et al. 2018

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Subanaesthetic ketamine has recently been proven to be a highly effective and fast acting alternative treatment for several psychiatric disorders. The mechanisms responsible for ketamine’s antidepressant effects remain unclear, but a possible explanation could be that ketamine interacts with regional cerebral blood flow (rCBF). Therefore, the effects of two subanaesthetic ketamine doses on rCBF were evaluated. Twelve dogs were randomly assigned to one of the three treatment conditions (condition saline, condition 0.5 mg/kg ketamine or condition 2 mg/kg ketamine) and received in total five saline or ketamine infusions, with one week interval. Single Photon Emission Computed Tomography (SPECT) scans with the radiotracer 99mTc-hexamethylpropylene amine oxime were performed before the start of the infusions (baseline) and 24 hours after the first (single) and last (multiple) infusion. After a wash out period of 3 months, the animals were again assigned to one of the three treatment conditions described above and the infusion/scan protocol was repeated. During the infusions, cardiovascular parameters were evaluated every ten minutes. A one-way repeated measure ANOVA was set up to assess perfusion index for each ketamine dose for the left frontal cortex (alpha = 0.05). The remaining 11 brain regions were post hoc assessed. Perfusion index was significantly increased in the left frontal cortex and in the thalamus 24 hours after single and multiple ketamine infusions compared to baseline in the 2 mg/kg condition. No clinically relevant cardiovascular effects were observed during the ketamine infusions. This study shows that subanaesthetic ketamine can increase neuronal perfusion and therefore alter neuronal function in brain regions involved in depression and anxiety disorders. These perfusion increases may possibly contribute to ketamine’s beneficial effects in these psychiatric disorders.

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“…Considerable efforts have been put into finding the genetic mutations and polymorphisms underlying these disorders by genetic mapping studies. However, to date, no genetic mutation or polymorphism underlying these disorders has been definitively identified by these studies (Cyranoski 2010; Peedicayil 2010). Another possibility for the inheritance pattern of these disorders involves epigenetics.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic management of major psychosis

Peedicayil

2011

Clin Epigenet

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Epigenetic mechanisms are thought to play a major role in the pathogenesis of the major psychoses (schizophrenia and bipolar disorder), and they may be the link between the environment and the genome in the pathogenesis of these disorders. This paper discusses the role of epigenetics in the management of major psychosis: (1) the role of epigenetic drugs in treating these disorders. At present, there are three categories of epigenetic drugs that are being actively investigated for their ability to treat psychosis: drugs inhibiting histone deacetylation; drugs decreasing DNA methylation; and drugs targeting microRNAs; and (2) the role of epigenetic mechanisms in electroconvulsive therapy in these disorders.

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Genetics: Pet project

Cited by 14 publications

References 12 publications

Assessment of the Factorial Structures of the C-BARQ in Japan

Assessment of the Factorial Structures of the C-BARQ in Japan

The influence of subanaesthetic ketamine on regional cerebral blood flow in healthy dogs measured with 99mTc-HMPAO SPECT

Epigenetic management of major psychosis

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