Genetics Underlying an Individualized Approach to Adult Spinal Disorders

Walker, Corey T.; Bonney, Phillip A.; Martirosyan, Nikolay L.; Theodore, Nicholas

doi:10.3389/fsurg.2016.00061

Cited by 8 publications

(3 citation statements)

References 90 publications

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“…Internal and external factors that lead to the disruption of IVD homeostasis include: (1) genetic factors. Genetic diversity studies can explain the susceptibility of certain populations to IDD [18,19]. Recent studies have found that long noncoding RNA can accelerate IDD by affecting the apoptosis of IVD cells and the synthesis of related proteins.…”

Section: Degeneration and Microenvironment Changesmentioning

confidence: 99%

Applications of Functionalized Hydrogels in the Regeneration of the Intervertebral Disc

Yan

Wang

Xiang

et al. 2021

BioMed Research International

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Intervertebral disc degeneration (IDD) is caused by genetics, aging, and environmental factors and is one of the leading causes of low back pain. The treatment of IDD presents many challenges. Hydrogels are biomaterials that possess properties similar to those of the natural extracellular matrix and have significant potential in the field of regenerative medicine. Hydrogels with various functional qualities have recently been used to repair and regenerate diseased intervertebral discs. Here, we review the mechanisms of intervertebral disc homeostasis and degeneration and then discuss the applications of hydrogel-mediated repair and intervertebral disc regeneration. The classification of artificial hydrogels and natural hydrogels is then briefly introduced, followed by an update on the development of functional hydrogels, which include noncellular therapeutic hydrogels, cellular therapeutic hydrogel scaffolds, responsive hydrogels, and multifunctional hydrogels. The challenges faced and future developments of the hydrogels used in IDD are discussed as they further promote their clinical translation.

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Section: Degeneration and Microenvironment Changesmentioning

confidence: 99%

Applications of Functionalized Hydrogels in the Regeneration of the Intervertebral Disc

Yan

Wang

Xiang

et al. 2021

BioMed Research International

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“…Spinal disorders involve structural changes in the components of the spine, including the bones, intervertebral discs, muscles, and ligaments, which may stimulate the spinal cord and spinal nerves ( 1 ). Neurological disorders encompass a wide range of conditions, including cerebrovascular diseases, neuroimmune disorders, central nervous system infections, peripheral nerve diseases, and spinal cord diseases ( 2 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

A bibliometric and visualization study of global research trends in sacral Tarlov cyst from 2000 to 2022

Lu,

Bao,

Wang

et al. 2024

Front. Surg.

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BackgroundSymptomatic sacral Tarlov cyst (STC) exerts a significant negative impact on the patient's quality of life, highlighting the significance of the increasing number of studies on STC. However, bibliometric analyses in this research field are scarce. Thus, this study aims to provide a comprehensive knowledge structure and identify the research trends of STC through bibliometrics.MethodsArticles related to STC from 2000 to 2022 were sourced from the Web of Science Core Collection database. VOSviewer 1.6.16, CiteSpace 6.1.6, GraphPad Prism 8.2.1 and R-package “bibliometrix” were used to analyse the data and generate knowledge maps.ResultsA total of 930 studies on STC from 2000 to 2022 were included. The findings revealed a consistent yet upward trend in the number of annual publications in this field. The United States, China and Turkey were the most prolific and influential countries contributing to this field, with the University of Illinois, the University of Maryland and the National Institute of Standards & Technology being the most notable research institutions. Key journals include World Neurosurgery [Impact Factor (IF) = 2.210], Journal of Vascular Surgery (IF = 4.860) and Journal of Neurosurgery-Spine (IF = 3.467). Additionally, Tarlov Mj, Tarlov E and Zachariah Mr exhibit the highest number of publications, making them the leading authors in this field. A twenty-year retrospection of research trends using keyword analysis reveals four principal directions, namely “definition”, “pathogenesis”, “diagnosis” and “treatment”. Currently, therapeutic surgical intervention is the key treatment for this disease, with future treatments primarily hinging on minimally invasive methodologies rooted in microendoscopic and endoscopic techniques.ConclusionThis pioneering, comprehensive scientific bibliometric study provides a holistic summary of STC research trends and hot spots spanning the past 22 years. The results identify existing research frontiers and chart maps for future studies, serving as a valuable reference for scholars vested in this field.

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“…Estes genes regulam a fisiologia do disco intervertebral, agindo sobre a estrutura, a homeostase e a regeneração, determinando assim os mecanismos de manutenção da estrutura discal. 11 O conhecimento destes genes poderá ajudar a definir os pacientes mais suscetíveis à DD, permitir intervenções mais precoces e, mais importante, ajudar no desenvolvimento de terapêuticas mais efetivas.…”

Section: Introductionunclassified

Untitled

2020

Rev Bras Ortop

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Palavras-chave► degeneração do disco intervertebral ► disco intervertebral ► genética ► polimorfismo genético ResumoA degeneração discal é uma condição que compromete as funções do disco intervertebral, podendo levar a vários processos patológicos importantes, como hérnias discais e estenoses de canal. Apesar de sua etiologia ainda ser desconhecida, cada vez mais estudos têm demonstrado o papel preponderante de fatores genéticos em detrimento de fatores ambientais. Com o objetivo de revisar o conhecimento atual sobre os genes associados à degeneração do disco intervertebral, foi realizada uma revisão narrativa da literatura inglesa nos últimos 10 anos sobre o tema. Concluímos que há uma série de genes que foram associados à degeneração discal em seres humanos, incluindo genes codificando colágeno I α-1 (COL1A1), colágeno IX (COL9A2 e COL9A3), colágeno XI (COL11A2), interleucina 6 (IL-6), agrecano (AGC1), receptor de vitamina D (VDR), metaloproteinase de matriz 3 (MMP-3), além de microRNAs. Dessa forma, a presente revisão enfatiza os últimos avanços na associação de genes com fenótipos de discos degenerados específicos, polimorfismos de nucleotídeos únicos, hereditariedade e interações genético-ambientais em relação à degeneração discal, com o intuito de permitir ao clínico entender esse mecanismo de degeneração e estar preparado para as novas terapêuticas que estão por vir baseadas na genética.

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Genetics Underlying an Individualized Approach to Adult Spinal Disorders

Cited by 8 publications

References 90 publications

Applications of Functionalized Hydrogels in the Regeneration of the Intervertebral Disc

Applications of Functionalized Hydrogels in the Regeneration of the Intervertebral Disc

A bibliometric and visualization study of global research trends in sacral Tarlov cyst from 2000 to 2022

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