Genipin crosslinked bioactive collagen/chitosan/hyaluronic acid injectable hydrogels structurally amended via covalent attachment of surface-modified silica particles

Lewandowska-Łańcucka, Joanna; Gilarska, Adriana; Buła, Aleksandra; Horak, Wojciech; Łatkiewicz, Anna; Nowakowska, Maria

doi:10.1016/j.ijbiomac.2019.06.184

Cited by 60 publications

(45 citation statements)

References 62 publications

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“…There are only a few papers in the scientific literature regarding hyaluronic acid blends with other natural polymers and synthetic polymers where interactions between biopolymers in mixtures have been scarcely described. Nevertheless, the interactions between collagen, hyaluronic acid, and chitosan in mixtures and materials based on collagen/hyaluronic acid/chitosan blend have been studied within the last 5 years [ 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 ] and new materials have been proposed.…”

Section: Ternary Blends Of Hyaluronic Acid Collagen and Chitosanmentioning

confidence: 99%

“…Such materials have potential in bone repair and in bone tissue engineering. It seems that 3D porous composites based on blends of chitosan, collagen, and hyaluronic acid can also be considered as a matrix for the incorporation of inorganic particles [ 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 ]. Additional crosslinking of such composites may offer materials with good biocompatibility and mechanical properties, which can be proper in bone tissue engineering.…”

Section: Ternary Blends Of Hyaluronic Acid Collagen and Chitosanmentioning

confidence: 99%

“…Nevertheless, the results showed that both scaffolds can provide the support required in tissue engineering and regenerative medicine [ 72 ]. Collagen, chitosan, and hyaluronic acid blends can be also crosslinked with genipin [ 73 ]. The above mentioned three biopolymers were used to prepare injectable and in situ gelating biomimetic hybrid materials for potential use in bone tissue engineering.…”

Section: Ternary Blends Of Hyaluronic Acid Collagen and Chitosanmentioning

confidence: 99%

“…Hybrids of various compositions were obtained, and their physicochemical and biological properties were studied. The in vitro cell culture studies showed that the materials developed are biocompatible as they support MG-63 cells adhesion, proliferation as well as alkaline phosphatase (ALP) expression [ 73 ].…”

Section: Ternary Blends Of Hyaluronic Acid Collagen and Chitosanmentioning

confidence: 99%

“…Film-forming properties can be useful for the preparation of wound-healing materials [ 2 , 63 , 64 , 65 , 66 , 67 , 79 , 80 ]. Mechanical properties of such materials can be modified by chemical and physical crosslinking [ 67 , 72 , 73 , 81 , 82 ]. Such modification may help in stimulating epithelium cells to proliferate, which are often needed to produce materials with improved biological properties for tissue engineering [ 81 , 82 ].…”

Section: Possible Application Of New Materials Based On the Blendsmentioning

confidence: 99%

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Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

et al. 2020

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In this review, we provide a report on recent studies in the field of research on the blends of hyaluronic acid with other natural polymers, namely collagen and chitosan. Hyaluronic acid has attracted significant interest in biomedical and cosmetic applications due to its interesting properties. In recent years, blends of hyaluronic acid with other polymers have been studied for new materials development. New materials may show improved properties that are important in the biomedical applications and in cosmetic preparations. In this review paper, the structure, preparation, and properties of hyaluronic acid blends with collagen and chitosan have been discussed and examples of new materials based on such blends have been presented. A comparison of the currently available information in the field has been shown. Future aspects in the field of hyaluronic acid blends and their applications in the biomedical and cosmetic industry have also been mentioned.

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Section: Ternary Blends Of Hyaluronic Acid Collagen and Chitosanmentioning

confidence: 99%

Section: Ternary Blends Of Hyaluronic Acid Collagen and Chitosanmentioning

confidence: 99%

Section: Ternary Blends Of Hyaluronic Acid Collagen and Chitosanmentioning

confidence: 99%

Section: Ternary Blends Of Hyaluronic Acid Collagen and Chitosanmentioning

confidence: 99%

Section: Possible Application Of New Materials Based On the Blendsmentioning

confidence: 99%

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Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

et al. 2020

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Unlocking the Potential of Hybrid Nanocomposite Hydrogels: Design, Mechanical Properties and Biomedical Performances

Li,

Nicolas,

Mura

2024

Adv Funct Materials

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Hybrid nanocomposite hydrogels consist of the homogeneous incorporation of nano‐objects in a hydrogel matrix. The latter, whether made of natural or synthetic materials, possesses a microporous, soft structure that makes it an ideal host for a variety of polymer and lipid‐based nano‐objects as well as metal‐ and silica‐based ones. By carefully choosing the composition and the proportions of the different constituents, hybrid hydrogels can display a wide array of properties, from simple enhancement of mechanical characteristics to specific bioactivity. This review aims to provide an overview of the state of the art in hybrid hydrogels highlighting key aspects that make them a promising choice for a variety of biomedical applications. Strategies for the preparation of hybrid hydrogels are discussed by covering the selection of individual components. The review will also explore the physico‐chemical and rheological characterization of these materials, which is essential for understanding their structure and function, ultimately satisfying specifications for the intended use. Successful examples of biomedical applications will also be presented, and the main challenges to be met will be discussed, with the aim of stimulating the research community to exploit the full potential of these materials.

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3D‐Printed Functional Hydrogel by DNA‐Induced Biomineralization for Accelerated Diabetic Wound Healing

et al. 2023

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Chronic wounds in diabetic patients are challenging because their prolonged inflammation makes healing difficult, thus burdening patients, society, and health care systems. Customized dressing materials are needed to effectively treat such wounds that vary in shape and depth. The continuous development of 3D‐printing technology along with artificial intelligence has increased the precision, versatility, and compatibility of various materials, thus providing the considerable potential to meet the abovementioned needs. Herein, functional 3D‐printing inks comprising DNA from salmon sperm and DNA‐induced biosilica inspired by marine sponges, are developed for the machine learning‐based 3D‐printing of wound dressings. The DNA and biomineralized silica are incorporated into hydrogel inks in a fast, facile manner. The 3D‐printed wound dressing thus generates provided appropriate porosity, characterized by effective exudate and blood absorption at wound sites, and mechanical tunability indicated by good shape fidelity and printability during optimized 3D printing. Moreover, the DNA and biomineralized silica act as nanotherapeutics, enhancing the biological activity of the dressings in terms of reactive oxygen species scavenging, angiogenesis, and anti‐inflammation activity, thereby accelerating acute and diabetic wound healing. These bioinspired 3D‐printed hydrogels produce using a DNA‐induced biomineralization strategy are an excellent functional platform for clinical applications in acute and chronic wound repair.

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Genipin crosslinked bioactive collagen/chitosan/hyaluronic acid injectable hydrogels structurally amended via covalent attachment of surface-modified silica particles

Cited by 60 publications

References 62 publications

Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

Unlocking the Potential of Hybrid Nanocomposite Hydrogels: Design, Mechanical Properties and Biomedical Performances

3D‐Printed Functional Hydrogel by DNA‐Induced Biomineralization for Accelerated Diabetic Wound Healing

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