Geniposide exerts protective effects on spinal cord injury in rats by inhibiting the IKKs/NF-κB signaling pathway

Li, Yuying; Qiu, Huiping; Yao, Shuang; Li, Qunfeng; Ding, Yuemin; Cao, Yuan; Chen, Xuming; Zhu, Xiaoping

doi:10.1016/j.intimp.2021.108158

Cited by 17 publications

(9 citation statements)

References 28 publications

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“…1a, the UV‐vis absorption spectrum of the GFP extract displayed three absorption peaks at 240 nm, 330 nm and 440 nm. In the ultraviolet region, the characteristic absorption peak at 240 nm could be ascribed to geniposide, and the absorption peak at 330 nm is cis ‐crocins (Li et al ., 2021). The characteristic absorption peak of trans ‐crocins is 440 nm in the visible light region (Shindo et al ., 2022), and these compounds are the main colour components of Gardenia yellow pigment.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the fate of key bioactive pigments and physical properties of steamed bread fortified with Gardenia fruit pomace

Fan,

Li,

et al. 2023

Int J of Food Sci Tech

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SummaryGardenia fruit pomace (GFP) is an industrial by‐product containing abundant bioactive components. Incorporating GFP into wheat flour improves the exterior quality of food and enhances healthy functions. This study developed a suitable GFP‐fortified wheat product by applying different cooking methods (steaming, boiling and baking). The fate of bioactive crocin derivatives, physical properties and in vitro digestion of GFP‐fortified wheat products was evaluated. The results showed that the steaming, boiling and baking treatments reduced the trans‐crocin‐4 content by 14.41%, 27.54% and 35.17%, respectively, but had no significant effect on geniposide. Combined with the colour change, the steaming treatment was suitable for developing GFP‐fortified steamed bread. With increasing GFP concentration, the increasing b* value indicated that the steamed bread developed a yellow hue. Meanwhile, GFP enrichment of steamed bread could retain most crocins and slow starch digestion by decreasing rapidly digestible starch content. Furthermore, the steamed bread with 1% GFP showed good overall sensory acceptance (flavour, taste, and mouthfeel). Therefore, GFP is a promising option for improving steamed bread's appearance and nutritional quality.

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Section: Resultsmentioning

confidence: 99%

Evaluation of the fate of key bioactive pigments and physical properties of steamed bread fortified with Gardenia fruit pomace

Fan,

Li,

et al. 2023

Int J of Food Sci Tech

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“…Multiple studies have shown that intervening substances usually have the effect of promoting the regeneration of injured tissues or organs and inhibiting inflammation. Li et al showed that geniposide significantly inhibits the activities of NF-κB and inflammatory factors such as TNF-α, IL-1β, NO, and PGE2, thus reducing tissue edema, inhibiting neutrophil infiltration, promoting spinal cord tissue repair and axonal myelination, and improving axonal regeneration and axoplasmic transport function at the injury site [ 27 ]. ADSCs and the conditioned media derived from ADSCs have also been reported to play a role in minipig liver injury, in promoting anti-apoptosis and regeneration [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Exosomes Derived from Adipose-Derived Mesenchymal Stem Cells on Pyroptosis and Regeneration of Injured Liver

Piao

Sang

Kou

et al. 2022

IJMS

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Although accumulating evidence indicates that exosomes have a positive therapeutic effect on hepatic ischemia–reperfusion injury (HIRI), studies focusing on the alleviation of liver injury by exosomes derived from adipose-derived mesenchymal stem cells (ADSCs-Exo) based on the inhibition of cell pyroptosis have not yet been reported. Exosomes contain different kinds of biologically active substances such as proteins, lipids, mRNAs, miRNAs, and signaling molecules. These molecules are widely involved in cell–cell communication, cell signal transmission, proliferation, migration, and apoptosis. Therefore, we investigated the positive effects exerted by ADSCs-Exo after hepatic ischemia–reperfusion with partial resection injury in rats. In this study, we found that the post-operative tail vein injection of ADSCs-Exo could effectively inhibit the expression of pyroptosis-related factors such as NLRP3, ASC, caspase-1, and GSDMD-N, and promote the expression of regeneration-related factors such as Cyclin D1 and VEGF. Moreover, we found that the above cellular activities were associated with the NF-κB and Wnt/β-catenin signaling pathways. According to the results, ADSCs and ADSCs-Exo can reduce pyroptosis in the injured liver and promote the expression of those factors related to liver regeneration, while they can inhibit the NF-κB pathway and activate the Wnt/β-catenin pathway. However, although adipose-derived mesenchymal stem cell (ADSC) transplantation can reduce liver injury, it leads to a significant increase in the pyroptosis-related protein GSDMD-N expression. In conclusion, our study shows that ADSCs-Exo has unique advantages and significance as a cell-free therapy to replace stem cells and still has a broad research prospect in the clinical diagnosis and treatment of liver injuries.

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“…Geniposide significantly restored spinal cord injury in rats, reduced spinal cord tissue edema, decreased the spinal cavity area, increased the number of nf-200 positive neurons and HRP-positive neurons, and regenerated axons with myelin sheath. Moreover, geniposide effectively alleviates inflammatory responses after spinal cord injury in rats by inhibiting the IKKs/NF-KB pathway, promoting motor function recovery and axon regeneration [ 84 ]. Geniposide also has a significant antithrombotic effect.…”

Section: Other Therapeutic Effects Of Geniposidementioning

confidence: 99%

Updated Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of Natural Product Geniposide

Liu

Chen

et al. 2022

Molecules

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At present, the potential of natural products in new drug development has attracted more and more scientists’ attention, and natural products have become an important source for the treatment of various diseases or important lead compounds. Geniposide, as a novel iridoid glycoside compound, is an active natural product isolated from the herb Gardenia jasminoides Ellis (GJ) for the first time; it is also the main active component of GJ. Recent studies have found that geniposide has multiple pharmacological effects and biological activities, including hepatoprotective activity, an anti-osteoporosis effect, an antitumor effect, an anti-diabetic effect, ananti-myocardial dysfunction effect, a neuroprotective effect, and other protective effects. In this study, the latest research progress of the natural product geniposide is systematically described, and the pharmacological effects, pharmacokinetics, and toxicity of geniposide are also summarized and discussed comprehensively. We also emphasize the major pathways modulated by geniposide, offering new insights into the pharmacological effects of geniposide as a promising drug candidate for multiple disorders.

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Geniposide exerts protective effects on spinal cord injury in rats by inhibiting the IKKs/NF-κB signaling pathway

Cited by 17 publications

References 28 publications

Evaluation of the fate of key bioactive pigments and physical properties of steamed bread fortified with Gardenia fruit pomace

Evaluation of the fate of key bioactive pigments and physical properties of steamed bread fortified with Gardenia fruit pomace

Effects of Exosomes Derived from Adipose-Derived Mesenchymal Stem Cells on Pyroptosis and Regeneration of Injured Liver

Updated Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of Natural Product Geniposide

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