Genome characteristics and molecular evolution of the human sapovirus variant GII.8

Xue, L.; Cai, Weiping; Gao, Junshan; Jiang, Yueting; Wu, Haoming; Zhang, Le; Zuo, Yueting; Dong, Ruimin; Pang, Rui; Zeng, Haiyan; Shi, Wei; Wang, Juan; Zhang, Jumei; Wu, Qingping

doi:10.1016/j.meegid.2019.05.017

Cited by 11 publications

(15 citation statements)

References 30 publications

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“…Based on the entire nucleotide sequence of VP1 region, SaV can be classified into 19 genogroups (GI-GXIX) and only four genogroups (GI, GII, GIV, and GV) known to infect human (Yinda et al, 2017). Human SaV can be further divided into 18 genotypes (GI.1 to GI.7, GII.1 to GII.8, GIV.1, GV.1, and GV.2) (Kagning Tsinda et al, 2017;Liu et al, 2016;Oka et al, 2012;Oka et al, 2015;Xue et al, 2019) with one additional genotype of GII.NA that has been reported recently (Diez-Valcarce et al, 2019). Among these, SaV GI and GII are the most prevalent genogroups detected worldwide while other genogroups have been rarely detected (Magwalivha et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Genetic recombination and diversity of sapovirus in pediatric patients with acute gastroenteritis in Thailand, 2010–2018

Khamrin

Ushijima

Chen

et al. 2020

PeerJ

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Background Human sapovirus (SaV) is an etiologic agent of acute gastroenteritis (AGE) in all age groups worldwide. Genetic recombination of SaV has been reported from many countries. So far, none of SaV recombinant strain has been reported from Thailand. This study examined the genetic recombination and genotype diversity of SaV in children hospitalized with AGE in Chiang Mai, Thailand. Methods Stool samples were collected from children suffering from diarrhea who admitted to the hospitals in Chiang Mai, Thailand between 2010 and 2018. SaV was detected by RT-PCR and the polymerase and capsid gene sequences were analysed. Results From a total of 3,057 samples tested, 50 (1.6%) were positive for SaV. Among positive samples, SaV genotype GI.1 was the most predominant genotype (40%; 20/50), followed by GII.1 and GII.5 (each of 16%; 8/50), GI.2 (14%; 7/50), GIV.1 (4%; 2/50), and GI.5 (2%; 1/50). In addition, 4 SaV recombinant strains of GII.1/GII.4 were identified in this study (8%; 4/50). Conclusions The data revealed the genetic diversity of SaV circulating in children with AGE in Chiang Mai, Thailand during 2010 to 2018 and the intragenogroup SaV recombinant strains were reported for the first time in Thailand.

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Section: Introductionmentioning

confidence: 99%

Genetic recombination and diversity of sapovirus in pediatric patients with acute gastroenteritis in Thailand, 2010–2018

Khamrin

Ushijima

Chen

et al. 2020

PeerJ

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“…The epidemiology of cases of AGE of viral etiology is a relevant public health issue [20] . Of note, reports on SaV-associated AGE across all age groups have recently increased worldwide [6,11,13] , which indicated that the cases caused by SaVs may become extensive and global. And Shenzhen is also one of the highincidence areas of SaV-associated outbreaks recently in mainland China [19,21] .…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, in 2019, Xue al. acquired the rst GII.8 SaV genome from mainland China [13] . Based on the phylogenetic analysis, the strain SZ08 in this study was classi ed as a member of GII.8 SaV.…”

Section: Discussionmentioning

confidence: 99%

“…ORF3 predicted for several SaVs strains encodes proteins with unknown function [2,7,9] . Based on complete capsid gene (VP1) sequences, multiple genetic clusters of human SaVs are divided into 4 genogroups (GI,GII,GIV,GV) with 20 genotypes (GI.1 to GI.7, GII.1 to GII.8, GIV.1 and GV.1 to GV.4) [11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

“…Recently, a novel genotype of SaVs, GII.8 strians were reported in some countries and one GII.8 SaV strain (GZ2014-l231) was detected in 2014 in Guangzhou city, Guangdong province of China [13] . In this study, an acute gastroenteritis outbreak caused by a novel GII.8 SaV variant occurred in primary school in the other city, Shenzhen city, Guangdong province of China in 2019.…”

Section: Introductionmentioning

confidence: 99%

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An Outbreak of Gastroenteritis Associated with a Novel GII.8 Sapovirus Variant-Transmitted by Vomit in Shenzhen, China, 2019

Yan

Wen³

et al. 2020

Preprint

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Human Sapovirus (SaVs) has been reported as one of the causative agents of acute gastroenteritis worldwide. We investigated an outbreak of SaV that affected 428 students of a primary school during spring activities from 24th February to 11th March 2019 in Shenzhen city, China. The single factor analysis showed that the students which saw others vomiting in classroom or playground, saw vomitus less than 1.5 meters are susceptible (P < 0.05). Seven of eleven fecal samples from patients were positive for GII.8 SaV genotype. In this study, we obtained the genome sequence of a sapovirus GII.8 strain SZ08 comprehensively analyzed the genetic diversity. The phylogenetic analysis showed that the GII.8 strain SZ08 formed an independent branch and became a novel variant of GII.8 genotype.

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Gastroenteritis Viruses

Hindiyeh,

Das,

Dunbar

2023

ClinMicroNow

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Acute viral gastroenteritis (AVG) is a common self‐limiting illness affecting infants, children, and adults worldwide. In developed countries, AVG is associated with significant morbidity in children and the elderly, while in developing countries these infections have been associated with high morbidity and mortality, especially in infants. The clinical manifestation of AVG is due to the effects that the virus and its specific cytotoxins exert on the enterocytes of the intestine. AVG can be triggered by many viruses, most often rotavirus, caliciviruses, enteric adenoviruses 40/41, and astroviruses. The luciferase immunoprecipitation system assay, a liquid‐phase immunoassay that quantifies antigen‐specific serum antibodies, has also been used for the quantitation of Norovirus antibodies. Antibody‐neutralization assays have been used for evaluating antibodies induced post RV vaccination. The major advantage of molecular diagnostic methods is the increased sensitivity and specificity for common viruses, such as rotaviruses and adenoviruses, and the ability to detect uncultivable viruses such as noroviruses, astroviruses, and sapoviruses.

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Genome characteristics and molecular evolution of the human sapovirus variant GII.8

Cited by 11 publications

References 30 publications

Genetic recombination and diversity of sapovirus in pediatric patients with acute gastroenteritis in Thailand, 2010–2018

Genetic recombination and diversity of sapovirus in pediatric patients with acute gastroenteritis in Thailand, 2010–2018

An Outbreak of Gastroenteritis Associated with a Novel GII.8 Sapovirus Variant-Transmitted by Vomit in Shenzhen, China, 2019

Gastroenteritis Viruses

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