Genome mining of sulfonated lanthipeptides reveals unique cyclic peptide sulfotransferases

Wang, Meng; Li, Wen-Wei; Cao, Zhe; Sun, Jianong; Xiong, Jiang; Tao, Si-Qin; Lv, Tinghong; Gao, Kun; Luo, Shangwen; Dong, Shi-Hui

doi:10.1016/j.apsb.2024.02.016

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Preprint1

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

An integrated platform for decoding hydrophilic peptide fingerprints of hepatocellular carcinoma using artificial intelligence and two-dimensional nanosheets

Li,

Ma,

Shui

et al. 2024

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

An integrated platform for decoding hydrophilic peptide fingerprints of hepatocellular carcinoma using artificial intelligence and two-dimensional nanosheets

Li,

Ma,

Shui

et al. 2024

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Decoding the chemical language of RiPPs from the untapped Archaea domain

Song,

Cai,

Gao

et al. 2024

Preprint

View full text Add to dashboard Cite

Chemical communication is crucial in ecosystems with complex microbial assemblages. However, due to archaeal cultivation challenges, our understanding of the structure diversity and function of secondary metabolites (SMs) within archaeal communities is limited compared to the extensively studied and well-documented bacterial counterparts. Our comprehensive investigation into the biosynthetic potential of archaea, combined with metabolic analyses and heterologous expression, has unveiled the previously unexplored biosynthetic capabilities and chemical diversity of Archaeal SMs. This represents the first reported instance of heterologous expression of archaeal SMs. We have identified twenty-four new lanthipeptides of RiPPs exhibiting unique chemical characteristics, including a novel subfamily featuring an unexplored type with diamino-dicarboxylic (DADC) termini, largely expanding the chemical landscape of Archaeal SMs. The maturation process of this noncanonical DADC lanthipeptide deviates from classical ones by cleaving amino acids within the thioether rings. This sheds light on the biosynthetic novelty of archaeal metabolites and emphasizes their potential as an untapped resource for SMs. Interestingly, archaeal lanthipeptides exhibit haloarchaea-specific antagonistic activity and enhance the host's motility, facilitating the archaeal interaction with biotic and abiotic environments. Our discoveries broaden our understanding of archaeal chemical language and provide promising prospects for future exploration of SM-mediated interactions in this domain.

show abstract

Genome mining of sulfonated lanthipeptides reveals unique cyclic peptide sulfotransferases

Cited by 2 publications

References 49 publications

An integrated platform for decoding hydrophilic peptide fingerprints of hepatocellular carcinoma using artificial intelligence and two-dimensional nanosheets

An integrated platform for decoding hydrophilic peptide fingerprints of hepatocellular carcinoma using artificial intelligence and two-dimensional nanosheets

Decoding the chemical language of RiPPs from the untapped Archaea domain

Contact Info

Product

Resources

About