2010
DOI: 10.1007/s00439-010-0899-z
|View full text |Cite
|
Sign up to set email alerts
|

Genome-scan for IQ discrepancy in autism: evidence for loci on chromosomes 10 and 16

Abstract: © Springer-Verlag 2010Correspondence to: Ellen M. Wijsman, wijsman@u.washington.edu. Electronic supplementary material The online version of this article (doi:10.1007/s00439-010-0899-z) contains supplementary material, which is available to authorized users. Conflict of interestAll authors report no conflicts of interest. Experiments conducted comply with the current laws of the country in which they were performed. NIH Public Access Author ManuscriptHum Genet. Author manuscript; available in PMC 2012 January … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
27
1

Year Published

2010
2010
2021
2021

Publication Types

Select...
10

Relationship

1
9

Authors

Journals

citations
Cited by 47 publications
(28 citation statements)
references
References 80 publications
0
27
1
Order By: Relevance
“…It is worth mentioning that other cadherin genes have been also associated with autistic phenotype (CDH13) [13] and extraversion as one of the five personality dimensions (CDH13 and CDH23) [14]. However, as the direction of association found by us was opposite to that found in autism spectrum disorders [12], the role of rs4307059 (or linked variants) in predisposition to suicide is not as straightforward as could be hypothesized.…”
Section: Discussioncontrasting
confidence: 49%
“…It is worth mentioning that other cadherin genes have been also associated with autistic phenotype (CDH13) [13] and extraversion as one of the five personality dimensions (CDH13 and CDH23) [14]. However, as the direction of association found by us was opposite to that found in autism spectrum disorders [12], the role of rs4307059 (or linked variants) in predisposition to suicide is not as straightforward as could be hypothesized.…”
Section: Discussioncontrasting
confidence: 49%
“…The differences in locomotion that we identify here display interactions with gender that are reminiscent of the influences of gender on ADHD diagnoses and/or symptomatology. CDH13 associations with cognitive function in children with ADHD or autism fit nicely with the influences of CDH13 variation on task acquisition that we note here (46)(47)(48). We failed to identify any significant influences of CDH13 variation on the sorts of impulsivity measured by 5-choice serial reaction time testing (49), although this "impulsivity" indicator may not assess all forms of impulsivity present in human disorders.…”
Section: Discussionmentioning
confidence: 53%
“…Until reasonably inferred functional alleles are associated in each disorder, it is not possible to directly address the issue of whether the same genetic variants within the same gene are relevant to both SLI and ASD (12, 48). Hence it is possible that SLI and ASD have some of the same key genes in pathogenesis but not the same underlying variants or molecular mechanisms.…”
Section: Discussionmentioning
confidence: 99%