“…It was also observed that the enrichment of genes in the neuroactive ligand-receptor interaction pathway ( CALCR , GRIA4 , GRM8 , GHR, MC5R, NPFFR2, PRLH, UCN3 ), PI3K-Akt signaling pathway ( CDKN1B, GHR, IL6, MTOR, OSM, SGK1 , TLR4 ), HIF-1 signaling pathway ( CDKN1B, IL6, MTOR and TLR4 ) and JAK–STAT signaling pathway ( LIF, GHR, IL6, MTOR and OSM ) with other pathways and stress responses ( Figure 3C ). In line with these pathways ( Figure 3C ), the previous studies found that the candidate genes for HS response enriched HSF1 mediated heat shock response, estrogen signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, MAPK singling pathway and immune response pathways in dairy cattle ( 93 , 112 , 113 ).…”