Genome-Wide Gene Expression Analysis to Identify Epistatic Gene-Pairs Associated with Prognosis of Breast Cancer

Gene–environment interaction identification via penalized robust divergence

“…It has been reported that HORMAD1 is overexpressed in TNBC, and its expression makes breast cancer cells sensitive to homologous repair-defect targeting agents by resulting in the deficiency of homologous recombination (Wang et al, 2018). In addition, FOXA1, MLPH, and SLC44A4 have been reported as downregulated in TNBC (He et al, 2015;Lin and Hsu, 2015). FOXC1, FAM171A1, RGMA, PSAT1, and UGT8 have been identified as upregulated in TNBC (Bao et al, 2019;Santuario et al, 2017).…”