Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations

Salo, Ville; Määttä, Juhani; Sliz, Eeva; ,; Palotie, Aarno; Daly, Mark; Riley-Gills, Bridget; Jacob, Howard; Paul, Dirk; Petrovski, Slavé; Runz, Heiko; John, Sally; Okafo, George; Lawless, Nathan; Salminen-Mankonen, Heli; Plenge, Robert; Maranville, Joseph; McCarthy, Mark; Ehm, Margaret G.; Auro, Kirsi; Longerich, Simonne; Mälarstig, Anders; Klinger, Katherine; Chatelain, Clement; Gossel, Matthias; Estrada, Karol; Graham, Robert; Yang, Robert; O´Donnell, Chris; Mäkelä, Tomi P.; Kaprio, Jaakko; Virolainen, Petri; Hakanen, Antti; Kilpi, Terhi; Perola, Markus; Partanen, Jukka; Pitkäranta, Anne; Raivio, Taneli; Tikkanen, Jani; Serpi, Raisa; Laitinen, Tarja; Kosma, Veli-Matti; Laukkanen, Jari; Hautalahti, Marco; Tuovila, Outi; Pakkanen, Raimo; Waring, Jeffrey; Rahimov, Fedik; Tachmazidou, Ioanna; Chen, Chia-Yen; Ding, Zhihao; Jung, Marc; Biswas, Shameek; Pendergrass, Rion; Pulford, David; Raghavan, Neha; Huertas-Vazquez, Adriana; Sul, Jae-Hoon; Hu, Xinli; Hedman, Åsa; Rivas, Manuel; Waterworth, Dawn; Renaud, Nicole; Obeidat, Ma´en; Ripatti, Samuli; Schleutker, Johanna; Arvas, Mikko; Carpén, Olli; Hinttala, Reetta; Mannermaa, Arto; Aalto-Setälä, Katriina; Kähönen, Mika; Mäkelä, Johanna; Kälviäinen, Reetta; Julkunen, Valtteri; Soininen, Hilkka; Remes, Anne; Hiltunen, Mikko; Peltola, Jukka; Raivio, Minna; Tienari, Pentti; Rinne, Juha; Kallionpää, Roosa; Partanen, Juulia; Abbasi, Ali; Ziemann, Adam; Smaoui, Nizar; Lehtonen, Anne; Eaton, Susan; Lahdenperä, Sanni; Bowers, Natalie; Teng, Edmond; Xu, Fanli; Addis, Laura; Eicher, John; Li, Qingqin S.; He, Karen; Khramtsova, Ekaterina; Färkkilä, Martti; Koskela, Jukka; Pikkarainen, Sampsa; Jussila, Airi; Kaukinen, Katri; Blomster, Timo; Kiviniemi, Mikko; Voutilainen, Markku; Lu, Tim; McCarthy, Linda; Hart, Amy; Guan, Meijian; Miller, Jason; Kalpala, Kirsi; Miller, Melissa; Eklund, Kari; Palomäki, Antti; Isomäki, Pia; Pirilä, Laura; Kaipiainen-Seppänen, Oili; Huhtakangas, Johanna; Mars, Nina; Lertratanakul, Apinya; Viollet, Coralie; Hochfeld, Marla; Gordillo, Jorge Esparza; Farias, Fabiana; Bing, Nan; Pelkonen, Margit; Kauppi, Paula; Kankaanranta, Hannu; Harju, Terttu; Lahesmaa, Riitta; Chen, Hubert; Betts, Joanna; Mishra, Rajashree; Mouded, Majd; Ngo, Debby; Niiranen, Teemu; Vaura, Felix; Salomaa, Veikko; Metsärinne, Kaj; Aittokallio, Jenni; Hernesniemi, Jussi; Gordin, Daniel; Sinisalo, Juha; Taskinen, Marja-Riitta; Tuomi, Tiinamaija; Hiltunen, Timo; Elliott, Amanda; Reeve, Mary Pat; Ruotsalainen, Sanni; Chu, Audrey; Reilly, Dermot; Mendelson, Mike; Parkkinen, Jaakko; Meretoja, Tuomo; Joensuu, Heikki; Mattson, Johanna; Salminen, Eveliina; Auranen, Annika; Karihtala, Peeter; Auvinen, Päivi; Elenius, Klaus; Pitkänen, Esa; Popovic, Relja; Fabre, Margarete; Schutzman, Jennifer; Kulkarni, Diptee; Porello, Alessandro; Loboda, Andrey; Lehtonen, Heli; McDonough, Stefan; Vuoti, Sauli; Kaarniranta, Kai; Turunen, Joni A.; Ollila, Terhi; Uusitalo, Hannu; Karjalainen, Juha; Liu, Mengzhen; Loomis, Stephanie; Strauss, Erich; Chen, Hao; Tasanen, Kaisa; Huilaja, Laura; Hannula-Jouppi, Katariina; Salmi, Teea; Peltonen, Sirkku; Koulu, Leena; Choy, David; Wu, Ying; Pussinen, Pirkko; Salminen, Aino; Salo, Tuula; Rice, David; Nieminen, Pekka; Palotie, Ulla; Siponen, Maria; Suominen, Liisa; Mäntylä, Päivi; Gursoy, Ulvi; Anttonen, Vuokko; Sipilä, Kirsi; Laivuori, Hannele; Kurra, Venla; Kotaniemi-Talonen, Laura; Heikinheimo, Oskari; Kalliala, Ilkka; Aaltonen, Lauri; Jokimaa, Varpu; Vääräsmäki, Marja; Uimari, Outi; Morin-Papunen, Laure; Niinimäki, Maarit; Piltonen, Terhi; Kivinen, Katja; Widen, Elisabeth; Tukiainen, Taru; Välimäki, Niko; Laakkonen, Eija; Tyrmi, Jaakko; Silven, Heidi; Arffman, Riikka; Savukoski, Susanna; Laisk, Triin; Pujol, Natalia; Kumar, Janet; Hovatta, Iiris; Isometsä, Erkki; Ollila, Hanna; Suvisaari, Jaana; Als, Thomas Damm; Mäkitie, Antti; Bizaki-Vallaskangas, Argyro; Toppila-Salmi, Sanna; Willberg, Tytti; Saarentaus, Elmo; Aarnisalo, Antti; Rahikkala, Elisa; Aittomäki, Kristiina; Åberg, Fredrik; Kurki, Mitja; Havulinna, Aki; Mehtonen, Juha; Hassan, Shabbeer; Della Briotta Parolo, Pietro; Zhou, Wei; Maasha, Mutaamba; Lemmelä, Susanna; Liu, Aoxing; Lehisto, Arto; Ganna, Andrea; Llorens, Vincent; Heyne, Henrike; Rämö, Joel; Rodosthenous, Rodos; Strausz, Satu; Palotie, Tuula; Palin, Kimmo; Gracia-Tabuenca, Javier; Siirtola, Harri; Kiiskinen, Tuomo; Lee, Jiwoo; Tsuo, Kristin; Kristiansson, Kati; Hyvärinen, Kati; Ritari, Jarmo; Pylkäs, Katri; Karjalainen, Minna; Mantere, Tuomo; Kangasniemi, Eeva; Heikkinen, Sami; Pitkänen, Nina; Lessard, Samuel; Kallio, Lila; Wahlfors, Tiina; Punkka, Eero; Siltanen, Sanna; Kuopio, Teijo; Jalanko, Anu; Shen, Huei-Yi; Kajanne, Risto; Aavikko, Mervi; Cooper, Helen; Öller, Denise; Leinonen, Rasko; Palin, Henna; Linna, Malla-Maria; Kanai, Masahiro; Zheng, Zhili; Lahtela, L. Elisa; Kaunisto, Mari; Kilpeläinen, Elina; Sipilä, Timo P.; Dada, Oluwaseun Alexander; Ghazal, Awaisa; Kytölä, Anastasia; Weldatsadik, Rigbe; Donner, Kati; Loukola, Anu; Laiho, Päivi; Sistonen, Tuuli; Kaiharju, Essi; Laukkanen, Markku; Järvensivu, Elina; Lähteenmäki, Sini; Männikkö, Lotta; Wong, Regis; Toivola, Auli; Brunfeldt, Minna; Mattsson, Hannele; Koskelainen, Sami; Hiekkalinna, Tero; Paajanen, Teemu; Pärn, Kalle; Kals, Mart; Luo, Shuang; Padmanabhuni, Shanmukha Sampath; Niemi, Marianna; Helminen, Mika; Luukkaala, Tiina; Vähätalo, Iida; Tammerluoto, Jyrki; Smith, Sarah; Southerington, Tom; Lehto, Petri; Reimann, Ene; Mägi, Reedik; ,; Metspalu, Andres; Nelis, Mari; Milani, Lili; Hudjashov, Georgi; Reis, Kadri; Elhanas, Abdelrahman G.; Reigo, Anu; Palta, Priit; Esko, Tõnu; Karppinen, Jaro; Kettunen, Johannes

doi:10.1038/s41467-024-53467-z

Nat Commun

2024

DOI: 10.1038/s41467-024-53467-z

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Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations

Ville Salo,

Juhani Määttä,

Eeva Sliz

et al.

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Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations

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