Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in <i><scp>HLA</scp>‐<scp>DRB</scp>1</i>

Martino, David; Ashley, Sarah; Koplin, Jennifer J.; Ellis, Justine A.; Saffery, Richard; Dharmage, Shyamali C.; Gurrin, Lyle C.; Matheson, Melanie C.; Kalb, Birgit; Marenholz, Ingo; Beyer, Kirsten; Lee, Y.‐A.; Hong, Xiumei; Wang, X.; Vukcevic, Damjan; Motyer, Allan; Leslie, Stephen; Allen, Katrina J.; Ferreira, Manuel

doi:10.1111/cea.12863

Cited by 46 publications

(46 citation statements)

References 38 publications

(44 reference statements)

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“…Apart from the Howell et al and Madore et al studies, three other studies reported an association with peanut allergy, but these associations did not survive multiple testing adjustment (Table ). These studies had smaller sample sizes in comparison with other studies which may have contributed to the lack of association.…”

Section: Resultsmentioning

confidence: 93%

“…Six of the nine studies that investigated HLA found associations with broad allele groups. With the exception of Savilahti et al who focused on cow's milk allergy, the remaining five studies investigated HLA in relation to peanut allergy . Savilahti et al did not find any significant associations with cow's milk allergy for HLA class II DR and DQ haplotypes.…”

Section: Resultsmentioning

confidence: 98%

“…We also identified five GWAS with either food or peanut allergy as an outcome. Four of these were carried out in children, and the other was carried out in a population across the ages of 1‐93 years …”

Section: Resultsmentioning

confidence: 99%

“…Included studies were of varying sample sizes with the smallest study having 30 food allergy Caucasian cases and 35 nonallergic Caucasian controls, while the largest study was a GWAS with 2197 European subjects (671 with food allergy, 144 nonallergic nonsensitized controls and 1382 European controls of uncertain phenotype) . The majority (n = 11) of included studies were conducted in only “Caucasian,” “European” or “White” populations, whereas 11 studies were carried out in predominantly Caucasian populations alongside other ethnicities (“Asians,” “Mixed” and “African American”) . Four others were carried out in Japanese populations, one was carried out in a Taiwanese population, and there were five studies where ethnicity was not mentioned …”

Section: Resultsmentioning

confidence: 99%

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Genetic determinants of paediatric food allergy: A systematic review

Suaini

Wang

Soriano

et al. 2019

Allergy

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Background The genetic determinants of food allergy have not been systematically reviewed. We therefore systematically reviewed the literature on the genetic basis of food allergy, identifying areas for further investigation. Methods We searched three electronic databases (MEDLINE, EMBASE and PubMed) on 9 January 2018. Two authors screened retrieved articles for review according to inclusion criteria and extracted relevant information on study characteristics and measures of association. Eligible studies included those that reported an unaffected nonatopic control group, had genetic information and were carried out in children. Results Of the 2088 studies retrieved, 32 met our inclusion criteria. Five were genome‐wide association studies, and the remaining were candidate gene studies. Twenty‐two of the studies were carried out in a predominantly Caucasian population with the remaining 10 from Asian‐specific populations or unspecified ethnicity. We found FLG, HLA, IL10, IL13, as well as some evidence for other variants (SPINK5, SERPINB and C11orf30) that are associated with food allergy. Conclusions Little genetic research has been carried out in food allergy, with FLG, HLA and IL13 being the most reproducible genes for an association with food allergy. Despite promising results, existing genetic studies on food allergy are inundated with issues such as inadequate sample size and absence of multiple testing correction. Few included replication analyses or population stratification measures. Studies addressing these limitations along with functional studies are therefore needed to unravel the mechanisms of action of the identified genes.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Genetic determinants of paediatric food allergy: A systematic review

Suaini

Wang

Soriano

et al. 2019

Allergy

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“…Hirsch et al. have looked for an associated between the use of antibiotics in each life and the subsequent development of food and other allergies. They used routine data from a large integrated United States health system.…”

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confidence: 99%